6YHF
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![BU of 6yhf by Molmil](/molmil-images/mine/6yhf) | Solution NMR Structure of APP TMD | Descriptor: | Amyloid-beta precursor protein | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHO
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![BU of 6yho by Molmil](/molmil-images/mine/6yho) | Solution NMR Structure of APP G38P mutant TM | Descriptor: | Amyloid-beta precursor protein G38P mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHP
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![BU of 6yhp by Molmil](/molmil-images/mine/6yhp) | Solution NMR Structure of APP V44M mutant TMD | Descriptor: | Amyloid-beta precursor protein V44M mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHX
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![BU of 6yhx by Molmil](/molmil-images/mine/6yhx) | Solution NMR Structure of APP I45T mutant TMD | Descriptor: | Amyloid-beta precursor protein I45T mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-31 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHI
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![BU of 6yhi by Molmil](/molmil-images/mine/6yhi) | Solution NMR Structure of APP G38L mutant TMD | Descriptor: | Amyloid-beta precursor protein G38L mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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3FCD
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![BU of 3fcd by Molmil](/molmil-images/mine/3fcd) | |
7YYI
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![BU of 7yyi by Molmil](/molmil-images/mine/7yyi) | |
7Z07
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![BU of 7z07 by Molmil](/molmil-images/mine/7z07) | |
7Z08
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![BU of 7z08 by Molmil](/molmil-images/mine/7z08) | |
7Z0B
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![BU of 7z0b by Molmil](/molmil-images/mine/7z0b) | |
7QAP
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![BU of 7qap by Molmil](/molmil-images/mine/7qap) | Three-dimensional structure of the PGAM5 G17L mutant TMD | Descriptor: | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2021-11-17 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. J.Biol.Chem., 298, 2022
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7QAL
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![BU of 7qal by Molmil](/molmil-images/mine/7qal) | Three-dimensional structure of the PGAM5 C12L mutant TMD | Descriptor: | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2021-11-17 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. J.Biol.Chem., 298, 2022
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7QAO
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![BU of 7qao by Molmil](/molmil-images/mine/7qao) | Three-dimensional structure of the PGAM5 C12S mutant TMD | Descriptor: | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2021-11-17 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. J.Biol.Chem., 298, 2022
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7QAM
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![BU of 7qam by Molmil](/molmil-images/mine/7qam) | Three-dimensional structure of the PGAM5 WT TMD | Descriptor: | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2021-11-17 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. J.Biol.Chem., 298, 2022
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3L3S
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![BU of 3l3s by Molmil](/molmil-images/mine/3l3s) | |
8RPQ
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![BU of 8rpq by Molmil](/molmil-images/mine/8rpq) | |
8RQ6
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![BU of 8rq6 by Molmil](/molmil-images/mine/8rq6) | |
5L4X
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![BU of 5l4x by Molmil](/molmil-images/mine/5l4x) | Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside | Descriptor: | Protein FimH, heptyl 4-deoxy-4-deoxy-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, B. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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5L4U
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![BU of 5l4u by Molmil](/molmil-images/mine/5l4u) | Crystal structure of FimH lectin domain in complex with 2-Fluoro-Heptylmannoside | Descriptor: | Protein FimH, heptyl 2-fluoro-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, B. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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5L4Y
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![BU of 5l4y by Molmil](/molmil-images/mine/5l4y) | Crystal structure of FimH lectin domain in complex with 4-Fluoro-Heptylmannoside | Descriptor: | Protein FimH, heptyl 4-deoxy-4-fluoro-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, B. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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5L4V
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![BU of 5l4v by Molmil](/molmil-images/mine/5l4v) | Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside | Descriptor: | Protein FimH, heptyl 3-deoxy-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, T. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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5L4T
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![BU of 5l4t by Molmil](/molmil-images/mine/5l4t) | Crystal structure of FimH lectin domain in complex with 2-Deoxy-Heptylmannoside | Descriptor: | Protein FimH, heptyl 2-deoxy-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, B. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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6G2R
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![BU of 6g2r by Molmil](/molmil-images/mine/6g2r) | Crystal structure of FimH in complex with a tetraflourinated biphenyl alpha D-mannoside | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]-2,3,5,6-tetrakis(fluoranyl)benzenecarbonitrile, SULFATE ION, ... | Authors: | Jakob, R.P, Schoenemann, W, Cramer, J, Muehlethaler, T, Daetwyler, P, Zihlmann, P, Fiege, B, Sager, C.P, Smiesko, M, Rabbani, S, Eris, D, Schwardt, O, Maier, T, Ernst, B. | Deposit date: | 2018-03-23 | Release date: | 2019-03-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Improvement of Aglycone pi-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists. Chemmedchem, 14, 2019
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6G2S
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![BU of 6g2s by Molmil](/molmil-images/mine/6g2s) | Crystal structure of FimH in complex with a pentaflourinated biphenyl alpha D-mannoside | Descriptor: | (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3,4,5-triol, SULFATE ION, Type 1 fimbrin D-mannose specific adhesin | Authors: | Jakob, R.P, Schoenemann, W, Cramer, J, Muehlethaler, T, Daetwyler, P, Zihlmann, P, Fiege, B, Sager, C.P, Smiesko, M, Rabbani, S, Eris, D, Schwardt, O, Maier, T, Ernst, B. | Deposit date: | 2018-03-23 | Release date: | 2019-03-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Improvement of Aglycone pi-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists. Chemmedchem, 14, 2019
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5L4W
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![BU of 5l4w by Molmil](/molmil-images/mine/5l4w) | Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside | Descriptor: | Protein FimH, heptyl 3-fluoro-alpha-D-mannopyranoside | Authors: | Jakob, R.P, Zihlmann, P, Rabbani, S, Maier, T, Ernst, B. | Deposit date: | 2016-05-26 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To Be Published
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