6OTT
| Structure of PurF in complex with ppApp | Descriptor: | Amidophosphoribosyltransferase, PurF, MAGNESIUM ION, ... | Authors: | Grant, R.A, Wang, B, Laub, M.T. | Deposit date: | 2019-05-03 | Release date: | 2019-11-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature, 575, 2019
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5CEG
| X-ray structure of toxin/anti-toxin complex from Mesorhizobium opportunistum | Descriptor: | Addiction module antidote protein, CopG/Arc/MetJ family, GLYCEROL, ... | Authors: | Aakre, C.D, Herrou, J, Crosson, S, Laub, M.T. | Deposit date: | 2015-07-06 | Release date: | 2015-11-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Evolving New Protein-Protein Interaction Specificity through Promiscuous Intermediates. Cell, 163, 2015
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6VWO
| Crystal structure of E. coli guanosine kinase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE, Inosine-guanosine kinase, ... | Authors: | Wang, B, Grant, R.A, Laub, M.T. | Deposit date: | 2020-02-20 | Release date: | 2020-10-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. Mol.Cell, 80, 2020
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6X0A
| X-ray structure of a chimeric ParDE toxin-antitoxin complex from Mesorhizobium opportunistum | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Plasmid stabilization system, Putative addiction module antidote protein, ... | Authors: | Lite, T.L, Grant, R.A, Laub, M.T. | Deposit date: | 2020-05-15 | Release date: | 2020-11-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library. Elife, 9, 2020
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6CZF
| The structure of E. coli PurF in complex with ppGpp-Mg | Descriptor: | Amidophosphoribosyltransferase, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION | Authors: | Wang, B, Grant, R.A, Laub, M.T. | Deposit date: | 2018-04-09 | Release date: | 2018-10-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat. Chem. Biol., 15, 2019
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4JAU
| Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | Deposit date: | 2013-02-19 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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4JAS
| Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase, MAGNESIUM ION, ... | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | Deposit date: | 2013-02-19 | Release date: | 2013-09-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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4JA2
| Structural basis of a rationally rewired protein-protein interface (RR468mutant V13P, L14I, I17M and N21V) | Descriptor: | ACETATE ION, MAGNESIUM ION, Response regulator, ... | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | Deposit date: | 2013-02-18 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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4JAV
| Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Histidine kinase, ... | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | Deposit date: | 2013-02-19 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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6VWP
| Crystal structure of E. coli guanosine kinase in complex with ppGpp | Descriptor: | GUANOSINE, GUANOSINE-5',3'-TETRAPHOSPHATE, Inosine-guanosine kinase, ... | Authors: | Wang, B, Grant, R.A, Laub, M.T. | Deposit date: | 2020-02-20 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. Mol.Cell, 80, 2020
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7TZV
| Structure of DriD C-domain bound to 9mer ssDNA | Descriptor: | DNA (5'-D(*TP*AP*GP*TP*CP*TP*AP*CP*T)-3'), WYL domain-containing protein | Authors: | Schumacher, M.A, Laub, M. | Deposit date: | 2022-02-16 | Release date: | 2022-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD. Genes Dev., 36, 2022
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7ZTB
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6OX6
| Crystal structure of the complex between the Type VI effector Tas1 and its immunity protein | Descriptor: | ACETATE ION, PA14_01140, Tas1 | Authors: | Ahmad, S, Stogios, P.J, Skarina, T, Whitney, J, Savchenko, A, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2019-05-13 | Release date: | 2019-09-18 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature, 575, 2019
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5YIU
| Caulobacter crescentus GcrA DNA-binding domain (DBD) | Descriptor: | Cell cycle regulatory protein GcrA | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5YIW
| Caulobacter crescentus GcrA DNA-binding domain (DBD) in complex with methylated dsDNA (crystal form 2) | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*(6MA)P*TP*TP*CP*GP*C)-3'), ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5YIV
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5YIX
| Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5Z7I
| Caulobacter crescentus GcrA DNA-binding domain(DBD)in complex with unmethylated dsDNA | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*AP*TP*TP*CP*GP*C*)-3'), ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2018-01-29 | Release date: | 2018-03-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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6CG8
| Structure of C. crescentus GapR-DNA | Descriptor: | DNA (5'-D(*TP*TP*AP*AP*AP*AP*TP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*AP*TP*TP*TP*TP*AP*A)-3'), UPF0335 protein B7Z12_12435 | Authors: | Schumacher, M.A. | Deposit date: | 2018-02-19 | Release date: | 2018-09-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. Cell, 175, 2018
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6CFX
| Bosea sp GapR solved in the presence of DNA | Descriptor: | PHOSPHATE ION, UPF0335 protein ASE63_04290 | Authors: | Schumacher, M.A. | Deposit date: | 2018-02-18 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. Cell, 175, 2018
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6CFY
| Bosea sp Root 381 apo GapR structure | Descriptor: | UPF0335 protein ASE63_04290 | Authors: | Schumacherr, M.A. | Deposit date: | 2018-02-18 | Release date: | 2018-09-12 | Last modified: | 2018-10-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. Cell, 175, 2018
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7TH0
| Escherichia coli RpnA-S | Descriptor: | Recombination-promoting nuclease RpnA | Authors: | Zhong, A, Hickman, A.B, Storz, G, Dyda, F. | Deposit date: | 2022-01-10 | Release date: | 2023-03-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Toxic antiphage defense proteins inhibited by intragenic antitoxin proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
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7U02
| Structure of the C. crescentus DriD C-domain bound to ssDNA | Descriptor: | DNA (5'-D(P*AP*CP*G)-3'), SULFATE ION, WYL domain-containing protein | Authors: | Schumacher, M.A. | Deposit date: | 2022-02-17 | Release date: | 2022-06-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD. Genes Dev., 36, 2022
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