1QPV
 
 | | YEAST COFILIN | | Descriptor: | YEAST COFILIN | | Authors: | Fedorov, A.A, Lappalainen, P, Fedorov, E.V, Drubin, D.G, Almo, S.C. | | Deposit date: | 1999-05-29 | | Release date: | 1999-06-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure determination of yeast cofilin.
Nat.Struct.Biol., 4, 1997
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1M4J
 | | CRYSTAL STRUCTURE OF THE N-TERMINAL ADF-H DOMAIN OF MOUSE TWINFILIN ISOFORM-1 | | Descriptor: | A6 gene product | | Authors: | Paavilainen, V.O, Merckel, M.C, Falck, S, Ojala, P.J, Pohl, E, Wilmanns, M, Lappalainen, P. | | Deposit date: | 2002-07-03 | | Release date: | 2002-11-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Conservation Between the Actin Monomer-binding Sites of Twinfilin and Actin-depolymerizing Factor (ADF)/Cofilin
J.Biol.Chem., 277, 2002
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1CYX
 | | QUINOL OXIDASE (PERIPLASMIC FRAGMENT OF SUBUNIT II WITH ENGINEERED CU-A BINDING SITE)(CYOA) | | Descriptor: | CYOA, DINUCLEAR COPPER ION | | Authors: | Wilmanns, M, Lappalainen, P, Kelly, M, Sauer-Eriksson, E, Saraste, M. | | Deposit date: | 1995-08-22 | | Release date: | 1996-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center.
Proc.Natl.Acad.Sci.USA, 92, 1995
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1WM4
 | | Solution structure of mouse coactosin, an actin filament binding protein | | Descriptor: | Coactosin-like protein | | Authors: | Hellman, M, Paavilainen, V.O, Naumanen, P, Lappalainen, P, Annila, A, Permi, P. | | Deposit date: | 2004-07-03 | | Release date: | 2004-11-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins
Febs Lett., 576, 2004
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2HD7
 | | Solution structure of C-teminal domain of twinfilin-1. | | Descriptor: | Twinfilin-1 | | Authors: | Hellman, M.H, Paavilainen, V.O, Annila, A, Lappalainen, P, Permi, P.I. | | Deposit date: | 2006-06-20 | | Release date: | 2007-02-06 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural basis and evolutionary origin of actin filament capping by twinfilin
Proc.Natl.Acad.Sci.Usa, 104, 2007
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7ZTD
 | | Non-muscle F-actin decorated with non-muscle tropomyosin 3.2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 3.2, actin, ... | | Authors: | Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2022-05-09 | | Release date: | 2023-01-11 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms.
Cell Rep, 42, 2023
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7ZTC
 | | Non-muscle F-actin decorated with non-muscle tropomyosin 1.6 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 1.6, actin, ... | | Authors: | Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2022-05-09 | | Release date: | 2023-01-11 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms.
Cell Rep, 42, 2023
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3DAW
 | | Structure of the actin-depolymerizing factor homology domain in complex with actin | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Paavilainen, V.O, Oksanen, E, Goldman, A, Lappalainen, P. | | Deposit date: | 2008-05-30 | | Release date: | 2008-07-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure of the actin-depolymerizing factor homology domain in complex with actin
J.Cell Biol., 182, 2008
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6YP9
 | | Rabbit muscle actin in complex with ADF-H and ATP-ATTO-488 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Kogan, K, Kotila, T, Lappalainen, P. | | Deposit date: | 2020-04-15 | | Release date: | 2020-12-09 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.564 Å) | | Cite: | A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics.
Nat Commun, 12, 2021
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3OK8
 | | I-BAR OF PinkBAR | | Descriptor: | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, GLYCEROL | | Authors: | Boczkowska, M, Rebowski, G, Saarikangas, J, Lappalainen, P, Dominguez, R. | | Deposit date: | 2010-08-24 | | Release date: | 2011-07-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
Nat.Struct.Mol.Biol., 18, 2011
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6FM2
 | | CARP domain of mouse cyclase-associated protein 1 (CAP1) bound to ADP-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Kotila, T.M, Kogan, K, Lappalainen, P. | | Deposit date: | 2018-01-30 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of actin monomer re-charging by cyclase-associated protein.
Nat Commun, 9, 2018
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1CYW
 | | QUINOL OXIDASE (PERIPLASMIC FRAGMENT OF SUBUNIT II) (CYOA) | | Descriptor: | CYOA | | Authors: | Wilmanns, M, Lappalainen, P, Kelly, M, Sauer-Eriksson, E, Saraste, M. | | Deposit date: | 1995-08-22 | | Release date: | 1996-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center.
Proc.Natl.Acad.Sci.USA, 92, 1995
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6RSW
 | | HFD domain of mouse CAP1 bound to the pointed end of G-actin | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | | Authors: | Kotila, T, Kogan, K, Lappalainen, P. | | Deposit date: | 2019-05-22 | | Release date: | 2019-11-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin.
Nat Commun, 10, 2019
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6RSQ
 | | Helical folded domain of mouse CAP1 | | Descriptor: | Adenylyl cyclase-associated protein 1, GLYCEROL | | Authors: | Kotila, T, Kogan, K, Lappalainen, P. | | Deposit date: | 2019-05-22 | | Release date: | 2019-11-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin.
Nat Commun, 10, 2019
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7Q8B
 | | Leishmania major actin filament in ADP-Pi state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION, ... | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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7Q8C
 | | Leishmania major actin filament in ADP-state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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7Q8S
 | | Leishmania major ADP-actin filament decorated with Leishmania major cofilin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADF/Cofilin, Actin, ... | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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1COF
 | | YEAST COFILIN, ORTHORHOMBIC CRYSTAL FORM | | Descriptor: | COFILIN | | Authors: | Fedorov, A.A, Lappalainen, P, Fedorov, E.V, Drubin, D.G, Almo, S.C. | | Deposit date: | 1996-11-26 | | Release date: | 1997-04-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure determination of yeast cofilin.
Nat.Struct.Biol., 4, 1997
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1CFY
 | | YEAST COFILIN, MONOCLINIC CRYSTAL FORM | | Descriptor: | COFILIN | | Authors: | Fedorov, A.A, Lappalainen, P, Fedorov, E.V, Drubin, D.G, Almo, S.C. | | Deposit date: | 1996-11-26 | | Release date: | 1997-04-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure determination of yeast cofilin.
Nat.Struct.Biol., 4, 1997
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8C47
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6ZH1
 | | Crystal structure of complex between FH19-20 and FhbA protein from Borrelia hermsii | | Descriptor: | 1,2-ETHANEDIOL, Complement factor H, Factor H-binding protein A, ... | | Authors: | Kogan, K, Kotila, T, Meri, T, Goldman, A. | | Deposit date: | 2020-06-20 | | Release date: | 2022-01-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mechanism of Borrelia immune evasion by FhbA-related proteins.
Plos Pathog., 18, 2022
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4NQI
 | | Structure of the N-terminal I-BAR domain (1-259) of D.Discoideum IBARa | | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, SH3 domain-containing protein | | Authors: | Witte, G, Faix, J, Runge-Wollmann, P. | | Deposit date: | 2013-11-25 | | Release date: | 2014-02-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis.
J.Cell.Sci., 127, 2014
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4BNE
 | | Pacsin2 Interacts with Membranes and Actin-Filaments | | Descriptor: | PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2, SULFATE ION, TRIETHYLENE GLYCOL | | Authors: | Kostan, J, Salzer, U, Orlova, A, Toeroe, I, Hodnik, V, Schreiner, C, Merilainen, J, Nikki, M, Virtanen, I, Lehto, V.-P, Anderluh, G, Egelman, E.H, Djinovic-Carugo, K. | | Deposit date: | 2013-05-15 | | Release date: | 2014-05-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Direct Interaction of Actin Filaments with F-Bar Protein Pacsin2.
Embo Rep., 15, 2014
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1HQZ
 | | Cofilin homology domain of a yeast actin-binding protein ABP1P | | Descriptor: | ACTIN-BINDING PROTEIN | | Authors: | Strokopytov, B.V, Fedorov, A.A, Mahoney, N, Drubin, D.G, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2000-12-20 | | Release date: | 2001-12-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches.
Acta Crystallogr.,Sect.D, 61, 2005
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4Z8G
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