1COF

YEAST COFILIN, ORTHORHOMBIC CRYSTAL FORM

Summary for 1COF

• Entry DOI: 10.2210/pdb1cof/pdb
• Descriptor: COFILIN (2 entities in total)
• Functional Keywords: actin-binding, cytoskeleton, actin-binding protein
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 15919.74

Authors

Fedorov, A.A.,Lappalainen, P.,Fedorov, E.V.,Drubin, D.G.,Almo, S.C. (deposition date: 1996-11-26, release date: 1997-04-01, Last modification date: 2024-02-07)

Primary citation

Fedorov, A.A.,Lappalainen, P.,Fedorov, E.V.,Drubin, D.G.,Almo, S.C.
Structure determination of yeast cofilin.
Nat.Struct.Biol., 4:366-369, 1997

PubMed Abstract: Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to actin monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cofilin function.

PubMed: 9145106
DOI: 10.1038/nsb0597-366

Experimental method

X-RAY DIFFRACTION (2.3 Å)