8K3Y
 
 | | The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. | | Deposit date: | 2023-07-17 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.42 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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4FWD
 | | Crystal structure of the Lon-like protease MtaLonC in complex with bortezomib | | Descriptor: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, TTC1975 peptidase | | Authors: | Chang, C.I, Kuo, C.I, Huang, K.F. | | Deposit date: | 2012-06-30 | | Release date: | 2013-06-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
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4FW9
 | | Crystal structure of the Lon-like protease MtaLonC | | Descriptor: | PHOSPHATE ION, TTC1975 peptidase | | Authors: | Chang, C.I, Ihara, K, Kuo, C.I, Huang, K.F, Wakatsuki, S. | | Deposit date: | 2012-06-30 | | Release date: | 2013-06-26 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
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4FWH
 | | Crystal structure of the Lon-like protease MtaLonC in complex with MG262 | | Descriptor: | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-leucinamide, PHOSPHATE ION, TTC1975 peptidase | | Authors: | Chang, C.I, Kuo, C.I, Huang, K.F. | | Deposit date: | 2012-07-01 | | Release date: | 2013-06-26 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
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4FWV
 | | Crystal structure of the N-terminal domain of the Lon-like protease MtaLonC | | Descriptor: | SULFATE ION, TTC1975 peptidase | | Authors: | Chang, C.I, Li, J.K, Kuo, C.I, Huang, K.F. | | Deposit date: | 2012-07-02 | | Release date: | 2013-06-26 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones
Acta Crystallogr.,Sect.D, 69, 2013
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4FWG
 | | Crystal structure of the Lon-like protease MtaLonC in complex with lactacystin | | Descriptor: | Omuralide, open form, PHOSPHATE ION, ... | | Authors: | Chang, C.I, Kuo, C.I, Huang, K.F. | | Deposit date: | 2012-07-01 | | Release date: | 2013-06-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
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7YPI
 | | Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPJ
 | | Spiral pentamer of the substrate-free Lon protease with a S678A mutation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPH
 | | Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPK
 | | Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7EV4
 | | Crystal structure of the Lon-like protease MtaLonC with S582A mutation in complex with F-b20-Q | | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-20 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EUY
 | | Crystal structure of the Lon-like protease MtaLonC with D582A mutation in complex with substrate polypeptide | | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-19 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EV6
 | | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with F-b20-Q | | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-20 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EUX
 | | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with substrate polypeptide | | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-19 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7W1G
 | | Crystal structure of YfiH with C107A mutation in complex with UDP-MurNAc-L-Serine | | Descriptor: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, (2S)-2-[[(2R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-2-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-6-(hydroxymethyl)-5-oxidanyl-oxan-4-yl]oxypropanoyl]amino]-3-oxidanyl-propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Lee, S.H, Hsieh, K.Y, Lee, M.S, Chang, C.I. | | Deposit date: | 2021-11-19 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
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7F3V
 | | Crystal structure of YfiH with C107A mutation in complex with endogenous UDP-MurNAc | | Descriptor: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ... | | Authors: | Lee, M.S, Hsieh, K.Y, Chang, C.I. | | Deposit date: | 2021-06-17 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
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7YUH
 | | MtaLon-Apo for the spiral oligomers of trimer | | Descriptor: | Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUU
 | | MtaLon-ADP for the spiral oligomers of trimer | | Descriptor: | Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUV
 | | MtaLon-ADP for the spiral oligomers of tetramer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUP
 | | MtaLon-Apo for the spiral oligomers of pentamer | | Descriptor: | Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUT
 | | MtaLon-Apo for the spiral oligomers of hexamer | | Descriptor: | Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUX
 | | MtaLon-ADP for the spiral oligomers of hexamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-18 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUW
 | | MtaLon-ADP for the spiral oligomers of pentamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-18 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUM
 | | MtaLon-Apo for the spiral oligomers of tetramer | | Descriptor: | Lon protease | | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-17 | | Release date: | 2023-10-25 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7FID
 | | Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | | Deposit date: | 2021-07-31 | | Release date: | 2021-11-24 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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