6NOW
 
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6NLQ
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6NLY
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4ZEM
 | | Crystal structure of eIF2B beta from Chaetomium thermophilum | | Descriptor: | Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2015-04-20 | | Release date: | 2015-09-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
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4ZEO
 | | Crystal structure of eIF2B delta from Chaetomium thermophilum | | Descriptor: | Translation initiation factor eif-2b-like protein | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2015-04-20 | | Release date: | 2015-09-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
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5DBO
 | | Crystal structure of the tetrameric eIF2B-beta2-delta2 complex from C. thermophilum | | Descriptor: | Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein, Translation initiation factor eif-2b-like protein | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2015-08-21 | | Release date: | 2015-10-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
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7TZB
 | | Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial | | Authors: | Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P. | | Deposit date: | 2022-02-15 | | Release date: | 2022-09-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
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4TMZ
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4TN1
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4TMW
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4TMV
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4TMT
 | | Translation initiation factor eIF5B (517-858) mutant D533A from C. thermophilum, bound to GTPgammaS | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2014-06-02 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
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4TMX
 | | Translation initiation factor eIF5B (517-858) mutant D533N from C. thermophilum, bound to GTP and sodium | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2014-06-02 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
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4N3S
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4N3G
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4NCF
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4N3N
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4NCN
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4NCL
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8FFY
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL) | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ... | | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | Deposit date: | 2022-12-11 | | Release date: | 2023-08-23 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Nat Commun, 14, 2023
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6O76
 | | Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain | | Descriptor: | CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic | | Authors: | Kuhle, B, Yang, X.L. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.787 Å) | | Cite: | CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7U2B
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL) | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ... | | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | Deposit date: | 2022-02-23 | | Release date: | 2022-09-14 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
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7U2A
 | | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU) | | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ... | | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | | Deposit date: | 2022-02-23 | | Release date: | 2022-09-14 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
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8P8X
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4NOX
 | | Structure of the nine-bladed beta-propeller of eIF3b | | Descriptor: | CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit B | | Authors: | Liu, Y, Neumann, P, Kuhle, B, Monecke, T, Ficner, R. | | Deposit date: | 2013-11-20 | | Release date: | 2014-09-17 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.722 Å) | | Cite: | Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit
Structure, 22, 2014
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