6YAH
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![BU of 6yah by Molmil](/molmil-images/mine/6yah) | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo peptides | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | Deposit date: | 2020-03-12 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (10.2 Å) | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv, 6, 2020
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6H7W
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![BU of 6h7w by Molmil](/molmil-images/mine/6h7w) | Model of retromer-Vps5 complex assembled on membrane. | Descriptor: | Putative vacuolar protein sorting-associated protein, Vacuolar protein sorting-associated protein 26-like protein, Vacuolar protein sorting-associated protein 29, ... | Authors: | Kovtun, O, Leneva, N, Ariotti, N, Rohan, T.S, Owen, D.J, Briggs, J.A.G, Collins, B.M. | Deposit date: | 2018-07-31 | Release date: | 2018-09-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (11.4 Å) | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561, 2018
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6YAF
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![BU of 6yaf by Molmil](/molmil-images/mine/6yaf) | AP2 on a membrane containing tyrosine-based cargo peptide | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | Deposit date: | 2020-03-12 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv, 6, 2020
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6YAI
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![BU of 6yai by Molmil](/molmil-images/mine/6yai) | Clathrin with bound beta2 appendage of AP2 | Descriptor: | AP-2 complex subunit beta, Clathrin heavy chain, Clathrin light chain | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | Deposit date: | 2020-03-12 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (9.2 Å) | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv, 6, 2020
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4QKV
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![BU of 4qkv by Molmil](/molmil-images/mine/4qkv) | |
4QKW
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![BU of 4qkw by Molmil](/molmil-images/mine/4qkw) | Crystal structure of the zebrafish cavin4a HR1 domain | Descriptor: | CHLORIDE ION, Muscle-related coiled-coil protein | Authors: | Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. | Deposit date: | 2014-06-10 | Release date: | 2015-03-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into the organization of the cavin membrane coat complex Dev.Cell, 31, 2014
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6YAE
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![BU of 6yae by Molmil](/molmil-images/mine/6yae) | AP2 core in physiological buffer | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Kane Dickson, V, Kovtun, O, Kelly, B.T, Owen, D.J, Briggs, J.A.G. | Deposit date: | 2020-03-12 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv, 6, 2020
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3OGO
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![BU of 3ogo by Molmil](/molmil-images/mine/3ogo) | Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 | Descriptor: | GFP-nanobody, Green fluorescent protein, ISOPROPYL ALCOHOL | Authors: | Kubala, M.H, Kovtun, O, Alexandrov, K, Collins, B.M. | Deposit date: | 2010-08-17 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci., 19, 2010
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7BL1
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![BU of 7bl1 by Molmil](/molmil-images/mine/7bl1) | human complex II-BATS bound to membrane-attached Rab5a-GTP | Descriptor: | Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O. | Deposit date: | 2021-01-17 | Release date: | 2021-03-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nat Commun, 12, 2021
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7BLR
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![BU of 7blr by Molmil](/molmil-images/mine/7blr) | Vps35/Vps29 arch of fungal membrane-assembled retromer:Vps5 (SNX-BAR) complex. | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | Deposit date: | 2021-01-18 | Release date: | 2021-02-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (9.3 Å) | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv, 7, 2021
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7BLP
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![BU of 7blp by Molmil](/molmil-images/mine/7blp) | Vps35/Vps29 arch of fungal membrane-assembled retromer:Grd19 complex | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | Deposit date: | 2021-01-18 | Release date: | 2021-02-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv, 7, 2021
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7BLN
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![BU of 7bln by Molmil](/molmil-images/mine/7bln) | VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | Deposit date: | 2021-01-18 | Release date: | 2021-02-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv, 7, 2021
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7BLO
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![BU of 7blo by Molmil](/molmil-images/mine/7blo) | VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | Descriptor: | 2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE, C-term (residues 493-54) of Wls (fitted sequence corresponds to hDMT1-II), Sorting nexin-3, ... | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | Deposit date: | 2021-01-18 | Release date: | 2021-03-03 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv, 7, 2021
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7BLQ
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![BU of 7blq by Molmil](/molmil-images/mine/7blq) | Vps26 dimer region of the fungal membrane-assembled retromer:Grd19 complex. | Descriptor: | 2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE, Sorting nexin-3, The C-terminal portion of Kex2 cargo, ... | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | Deposit date: | 2021-01-18 | Release date: | 2021-03-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (9.2 Å) | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly. Sci Adv, 7, 2021
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4PQP
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![BU of 4pqp by Molmil](/molmil-images/mine/4pqp) | Crystal structure of human SNX14 PX domain in space group P43212 | Descriptor: | GLYCEROL, Sorting nexin-14 | Authors: | Mas, C, Norwood, S, Bugarcic, A, Kinna, G, Leneva, N, Kovtun, O, Teasdale, R, Collins, B. | Deposit date: | 2014-03-03 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling. J.Biol.Chem., 289, 2014
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4PQO
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![BU of 4pqo by Molmil](/molmil-images/mine/4pqo) | Structure of the human SNX14 PX domain in space group I41 | Descriptor: | Sorting nexin-14 | Authors: | Mas, C, Norwood, S, Bugarcic, A, Kinna, G, Leneva, N, Kovtun, O, Teasdale, R, Collins, B. | Deposit date: | 2014-03-03 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling. J.Biol.Chem., 289, 2014
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5W8M
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![BU of 5w8m by Molmil](/molmil-images/mine/5w8m) | Crystal structure of Chaetomium thermophilum Vps29 | Descriptor: | GLYCEROL, TRIETHYLENE GLYCOL, Vacuolar protein sorting-associated protein 29 | Authors: | Collins, B.M, Leneva, N. | Deposit date: | 2017-06-21 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561, 2018
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8FUD
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![BU of 8fud by Molmil](/molmil-images/mine/8fud) | |
7Z5C
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![BU of 7z5c by Molmil](/molmil-images/mine/7z5c) | Chimera of AP2 with FCHO2 linker domain as a fusion on Cmu2 subunit | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Kane Dickson, V, Qu, K, Owen, D.J, Briggs, J.A, Zaccai, N.R. | Deposit date: | 2022-03-09 | Release date: | 2022-05-11 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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4LFT
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![BU of 4lft by Molmil](/molmil-images/mine/4lft) | Structure of alpha-elapitoxin-Dpp2d isolated from Black Mamba (Dendroaspis polylepis) venom | Descriptor: | Alpha-elapitoxin-Dpp2a | Authors: | Wang, C.I.A, Reeks, T, Lewis, R.J, Alewood, P.F, Durek, T. | Deposit date: | 2013-06-27 | Release date: | 2014-06-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Isolation and Structural and Pharmacological Characterization of alpha-Elapitoxin-Dpp2d, an Amidated Three Finger Toxin from Black Mamba Venom. Biochemistry, 53, 2014
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7OIT
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![BU of 7oit by Molmil](/molmil-images/mine/7oit) | Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (P3221 crystal form) | Descriptor: | AP-2 complex subunit mu, F-BAR domain only protein 2, GLYCEROL | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | Deposit date: | 2021-05-12 | Release date: | 2022-06-01 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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7OG1
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![BU of 7og1 by Molmil](/molmil-images/mine/7og1) | AP2 clathrin adaptor core in complex with cargo peptide and FCHO2 | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | Deposit date: | 2021-05-05 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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7OHO
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![BU of 7oho by Molmil](/molmil-images/mine/7oho) | Crystal structure of AP2 FCHO2 chimera | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta,F-BAR domain only protein 2, AP-2 complex subunit mu, ... | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | Deposit date: | 2021-05-11 | Release date: | 2022-06-01 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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7OIQ
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![BU of 7oiq by Molmil](/molmil-images/mine/7oiq) | Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (C2 crystal form) | Descriptor: | AP-2 complex subunit mu, F-BAR domain only protein 2 | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | Deposit date: | 2021-05-12 | Release date: | 2022-06-01 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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7OHZ
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![BU of 7ohz by Molmil](/molmil-images/mine/7ohz) | Crystal structure of AP2 Mu2 - FCHO2 chimera (His6-tagged) | Descriptor: | AP-2 complex subunit mu,F-BAR domain only protein 2 | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | Deposit date: | 2021-05-11 | Release date: | 2022-06-01 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch. Sci Adv, 8, 2022
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