1TGN
 
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1NTP
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3PGF
 | | Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | | Descriptor: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | | Authors: | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | | Deposit date: | 2010-11-01 | | Release date: | 2011-03-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
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1CA0
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO APPI | | Descriptor: | BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | | Authors: | Scheidig, A.J, Kossiakoff, A.A. | | Deposit date: | 1997-01-23 | | Release date: | 1997-07-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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7ZYI
 | | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | | Descriptor: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | | Authors: | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2022-05-24 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
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7PIJ
 | | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | Descriptor: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2021-08-20 | | Release date: | 2021-09-01 | | Last modified: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
 | | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | Descriptor: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2021-08-18 | | Release date: | 2021-09-01 | | Last modified: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (8.45 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHP
 | | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | | Descriptor: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2021-08-18 | | Release date: | 2021-09-01 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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1CBW
 | | BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI | | Descriptor: | BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION | | Authors: | Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. | | Deposit date: | 1996-12-22 | | Release date: | 1997-07-23 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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1TAW
 | | BOVINE TRYPSIN COMPLEXED TO APPI | | Descriptor: | CALCIUM ION, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, TRYPSIN | | Authors: | Hynes, T.R, Kossiakoff, A.A. | | Deposit date: | 1996-12-19 | | Release date: | 1997-06-24 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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5W2B
 | | Crystal structure of C-terminal domain of Ebola (Reston) nucleoprotein in complex with Fab fragment | | Descriptor: | Fab Heavy Chain, Fab Light Chain, Nucleoprotein | | Authors: | Radwanska, M.J, Derewenda, U, Kossiakoff, A.A, Derewenda, Z.S. | | Deposit date: | 2017-06-06 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.
Acta Crystallogr D Struct Biol, 74, 2018
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1KF9
 | | PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR | | Descriptor: | EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE | | Authors: | Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A. | | Deposit date: | 2001-11-19 | | Release date: | 2002-11-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
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3BOG
 | | Snow Flea Antifreeze Protein Quasi-racemate | | Descriptor: | 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND | | Authors: | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | | Deposit date: | 2007-12-17 | | Release date: | 2008-09-23 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers
J.Am.Chem.Soc., 130, 2008
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3BOI
 | | Snow Flea Antifreeze Protein Racemate | | Descriptor: | 6.5 kDa glycine-rich antifreeze protein | | Authors: | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | | Deposit date: | 2007-12-17 | | Release date: | 2008-09-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers
J.Am.Chem.Soc., 130, 2008
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1AAL
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8RQF
 | | Cryo-EM structure of human NTCP-Bulevirtide complex | | Descriptor: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | | Authors: | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | | Deposit date: | 2024-01-18 | | Release date: | 2024-03-27 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
Nat Commun, 15, 2024
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6RLX
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6SNI
 | | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | | Descriptor: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | Deposit date: | 2019-08-24 | | Release date: | 2020-03-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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6SNH
 | | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | | Descriptor: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | | Authors: | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | | Deposit date: | 2019-08-24 | | Release date: | 2020-03-11 | | Last modified: | 2020-04-01 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure and mechanism of the ER-based glucosyltransferase ALG6.
Nature, 579, 2020
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8PG0
 | | Human OATP1B3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2023-06-17 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
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8PHW
 | | Human OATP1B1 | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ... | | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2023-06-20 | | Release date: | 2023-09-27 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
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1D9C
 | | BOVINE INTERFERON-GAMMA AT 2.0 ANGSTROMS | | Descriptor: | INTERFERON-GAMMA | | Authors: | Randal, M, Kossiakoff, A.A. | | Deposit date: | 1999-10-27 | | Release date: | 1999-11-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
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1D9G
 | | BOVINE INTERFERON-GAMMA AT 2.9 ANGSTROMS | | Descriptor: | INTERFERON-GAMMA | | Authors: | Randal, M, Kossiakoff, A.A. | | Deposit date: | 1999-10-27 | | Release date: | 1999-11-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
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7TBM
 | | Composite structure of the dilated human nuclear pore complex (NPC) generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | | Descriptor: | DDX19, NUP107 CTD, NUP107 NTD, ... | | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-15 | | Last modified: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (37 Å) | | Cite: | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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7TBL
 | | Composite structure of the human nuclear pore complex (NPC) cytoplasmic face generated with a 12A cryo-ET map of the purified HeLa cell NPC | | Descriptor: | DDX19, ELYS, GLE1, ... | | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (23 Å) | | Cite: | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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