9B3B
| Structure of TDP1 complexed with compound IB09 | Descriptor: | (8M)-8-{4-(benzylcarbamoyl)-2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke, T.R. | Deposit date: | 2024-03-18 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structure of TDP1 complexed with compound IB09 To Be Published
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8UV1
| Structure of TDP1 complexed with compound IB01 | Descriptor: | 1,2-ETHANEDIOL, 8-(fluorosulfonyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke, T.R. | Deposit date: | 2023-11-02 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure of TDP1 complexed with compound IB01 To Be Published
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8V0C
| Structure of TDP1 catalytic domain complexed with compound IB06 | Descriptor: | (8M)-8-(2-{[2-(fluorosulfonyl)ethyl]amino}phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | Deposit date: | 2023-11-17 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structures of TDP1 complexed with inhibitors To Be Published
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8UZV
| Structure of TDP1 catalytic domain complexed with compound IB02 | Descriptor: | 1,2-ETHANEDIOL, 8-{[2-(fluorosulfonyl)ethyl]amino}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | Deposit date: | 2023-11-16 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | Structure of TDP1 catalytic domain complexed with compound IB02 To Be Published
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8UZZ
| Structure of TDP1 catalytic domain complexed with compound IB03 | Descriptor: | (8M)-8-{2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | Deposit date: | 2023-11-16 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structureal analysis of TDP1 in complex with inhbitors To Be Published
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8V0B
| Structure of TDP1 catalytic domain complexed with compound IB05 | Descriptor: | 1,2-ETHANEDIOL, 8-{4-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. | Deposit date: | 2023-11-17 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structures of TDP1 complexed with inhibitors To Be Published
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6Z01
| DNA Topoisomerase | Descriptor: | CHLORIDE ION, DNA topoisomerase I | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | Deposit date: | 2020-05-07 | Release date: | 2021-11-17 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
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6Z03
| DNA Topoisomerase | Descriptor: | DNA topoisomerase I | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | Deposit date: | 2020-05-07 | Release date: | 2021-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
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