Summary for 9B3B
Entry DOI | 10.2210/pdb9b3b/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, (8M)-8-{4-(benzylcarbamoyl)-2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, drug target, cancer, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 105820.28 |
Authors | Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke, T.R. (deposition date: 2024-03-18, release date: 2024-09-25) |
Primary citation | Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke, T.R. Structure of TDP1 complexed with compound IB09 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
Download full validation report