Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1CTN
DownloadVisualize
BU of 1ctn by Molmil
CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION
Descriptor: CHITINASE A
Authors:Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E.
Deposit date:1994-10-10
Release date:1995-02-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a bacterial chitinase at 2.3 A resolution.
Structure, 2, 1994
6QCG
DownloadVisualize
BU of 6qcg by Molmil
PCNA complex with Cdt1 N-terminal PIP-box peptide
Descriptor: DNA replication factor Cdt1, Proliferating cell nuclear antigen
Authors:Perrakis, A, von Castelmur, E.
Deposit date:2018-12-28
Release date:2019-01-23
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1.
Life Sci Alliance, 1, 2018
8ARF
DownloadVisualize
BU of 8arf by Molmil
Crystal structure of the N-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein Spindly
Descriptor: Protein Spindly
Authors:Perrakis, A, Ahmad, M.U.
Deposit date:2022-08-16
Release date:2022-09-07
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.
J.Cell Biol., 221, 2022
6NVQ
DownloadVisualize
BU of 6nvq by Molmil
Crystal structure of the VASH1-SVBP complex
Descriptor: GLYCEROL, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Adamopoulos, A, Perrakis, A, Heidebrecht, T.
Deposit date:2019-02-05
Release date:2019-05-22
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Nat.Struct.Mol.Biol., 26, 2019
7P0K
DownloadVisualize
BU of 7p0k by Molmil
Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand
Descriptor: 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands
J Med Chem, 64, 2021
7A5U
DownloadVisualize
BU of 7a5u by Molmil
Structure of E37A BlaC from Mycobacterium tuberculosis
Descriptor: Beta-lactamase
Authors:Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M.
Deposit date:2020-08-21
Release date:2021-04-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conserved residues Glu37 and Trp229 play an essential role in protein folding of beta-lactamase.
Febs J., 288, 2021
7A74
DownloadVisualize
BU of 7a74 by Molmil
Structure of G132N BlaC from Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ...
Authors:Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M.
Deposit date:2020-08-27
Release date:2021-05-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics.
Antimicrob.Agents Chemother., 65, 2021
6FPV
DownloadVisualize
BU of 6fpv by Molmil
A llama-derived JBP1-targeting nanobody
Descriptor: GLYCEROL, Nanobody
Authors:van Beusekom, B, Adamopoulos, A, Heidebrecht, T, Joosten, R.P, Perrakis, A.
Deposit date:2018-02-12
Release date:2018-10-31
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5DLV
DownloadVisualize
BU of 5dlv by Molmil
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA)
Descriptor: 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Keune, W.J, Heidebrecht, T, von Castelmur, E, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5DLT
DownloadVisualize
BU of 5dlt by Molmil
Crystal structure of Autotaxin (ENPP2) with 7-alpha-hydroxycholesterol
Descriptor: 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5DLW
DownloadVisualize
BU of 5dlw by Molmil
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, CALCIUM ION, ...
Authors:Keune, W.J, Heidebrecht, T, Joosten, R.P, Perrakis, A.
Deposit date:2015-09-07
Release date:2016-04-13
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nat Commun, 7, 2016
5C9N
DownloadVisualize
BU of 5c9n by Molmil
Crystal structure of GEMC1 coiled-coil domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Geminin coiled-coil domain-containing protein 1
Authors:Caillat, C, Perrakis, A.
Deposit date:2015-06-28
Release date:2015-11-11
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.
Acta Crystallogr.,Sect.D, 71, 2015
4PGC
DownloadVisualize
BU of 4pgc by Molmil
MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGN(3,5-diiodotyrosine)PAL
Descriptor: Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ...
Authors:Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J.
Deposit date:2014-05-01
Release date:2015-01-07
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
3KJY
DownloadVisualize
BU of 3kjy by Molmil
Crystal structure of reduced HOMO SAPIENS CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-11-04
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
6GVJ
DownloadVisualize
BU of 6gvj by Molmil
Human Mps1 kinase domain with ordered activation loop
Descriptor: CHLORIDE ION, Dual specificity protein kinase TTK, GLYCEROL
Authors:Roorda, J.C, Hiruma, Y, Joosten, R.P, Perrakis, A.
Deposit date:2018-06-21
Release date:2019-01-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.
Proteins, 87, 2019
2CKL
DownloadVisualize
BU of 2ckl by Molmil
Ring1b-Bmi1 E3 catalytic domain structure
Descriptor: IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ...
Authors:Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K.
Deposit date:2006-04-20
Release date:2006-05-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
3G73
DownloadVisualize
BU of 3g73 by Molmil
Structure of the FOXM1 DNA binding
Descriptor: DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ...
Authors:Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
5IJQ
DownloadVisualize
BU of 5ijq by Molmil
Crystal structure of autotaxin (ENPP2) re-refined
Descriptor: 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2016-03-02
Release date:2016-06-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
5IJS
DownloadVisualize
BU of 5ijs by Molmil
Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ...
Authors:Hausmann, J, Joosten, R.P, Perrakis, A.
Deposit date:2016-03-02
Release date:2016-06-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
5O91
DownloadVisualize
BU of 5o91 by Molmil
Crystal structure of human Mps1 (TTK) C604W mutant in complex with Cpd-5
Descriptor: 1,2-ETHANEDIOL, Dual specificity protein kinase TTK, ~{N}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide
Authors:Hiruma, Y, Joosten, R.P, Perrakis, A.
Deposit date:2017-06-15
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
J. Biol. Chem., 292, 2017
3FY7
DownloadVisualize
BU of 3fy7 by Molmil
Crystal structure of homo sapiens CLIC3
Descriptor: Chloride intracellular channel protein 3, SULFATE ION
Authors:Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A.
Deposit date:2009-01-22
Release date:2009-02-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
5NTT
DownloadVisualize
BU of 5ntt by Molmil
Crystal structure of human Mps1 (TTK) C604Y mutant in complex with NMS-P715
Descriptor: 1,2-ETHANEDIOL, Dual specificity protein kinase TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE
Authors:Hiruma, Y, Joosten, R.P, Perrakis, A.
Deposit date:2017-04-28
Release date:2017-07-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
J. Biol. Chem., 292, 2017
9QYF
DownloadVisualize
BU of 9qyf by Molmil
PARP9 Macro Domain 2 in complex with ADPr
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Protein mono-ADP-ribosyltransferase PARP9, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Fourkiotis, K.N, Chikunova, A, Tsika, C.A, Kravvariti, P.K, Tsatsouli, A.S, Perrakis, A, Spyroulias, A.G.
Deposit date:2025-04-17
Release date:2025-05-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Comparative analysis of hPARP9 macro domains
To Be Published
9QYD
DownloadVisualize
BU of 9qyd by Molmil
PARP9 Macro domain 1, Free form
Descriptor: GLYCEROL, MALONATE ION, Protein mono-ADP-ribosyltransferase PARP9
Authors:Fourkiotis, N.K, Chikunova, A, Tsika, C.A, Tsatsouli, A.S, Perrakis, A, Spyroulias, G.A.
Deposit date:2025-04-17
Release date:2025-05-28
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Comparative analysis of hPARP9 macro domains
To Be Published
9QYH
DownloadVisualize
BU of 9qyh by Molmil
PARP9 Macro Domain 2 in complex with NAD+
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Protein mono-ADP-ribosyltransferase PARP9
Authors:Fourkiotis, K.N, Chikunova, A, Tsika, C.A, Kravvariti, P.K, Tsatsouli, A.S, Perrakis, A, Spyroulias, A.G.
Deposit date:2025-04-17
Release date:2025-05-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparative analysis of hPARP9 macro domains
To Be Published

238895

건을2025-07-16부터공개중

PDB statisticsPDBj update infoContact PDBjnumon