5O91

Crystal structure of human Mps1 (TTK) C604W mutant in complex with Cpd-5

Summary for 5O91

Entry DOI	10.2210/pdb5o91/pdb
Descriptor	Dual specificity protein kinase TTK, ~{N}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	mps1, ttk, kinase, inhibitor, cpd-5, mutant, c604w, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36841.11
Authors	Hiruma, Y.,Joosten, R.P.,Perrakis, A. (deposition date: 2017-06-15, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Hiruma, Y.,Koch, A.,Hazraty, N.,Tsakou, F.,Medema, R.H.,Joosten, R.P.,Perrakis, A. Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. J. Biol. Chem., 292:14496-14504, 2017 Cited by PubMed: 28726638 DOI: 10.1074/jbc.M117.783555 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation