5NTT

Crystal structure of human Mps1 (TTK) C604Y mutant in complex with NMS-P715

Summary for 5NTT

Entry DOI	10.2210/pdb5ntt/pdb
Descriptor	Dual specificity protein kinase TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	mps1, ttk, kinase, inhibitor, nms-p715, mutant, c604y, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34189.04
Authors	Hiruma, Y.,Joosten, R.P.,Perrakis, A. (deposition date: 2017-04-28, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Hiruma, Y.,Koch, A.,Hazraty, N.,Tsakou, F.,Medema, R.H.,Joosten, R.P.,Perrakis, A. Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. J. Biol. Chem., 292:14496-14504, 2017 Cited by PubMed: 28726638 DOI: 10.1074/jbc.M117.783555 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation