5NTT
Crystal structure of human Mps1 (TTK) C604Y mutant in complex with NMS-P715
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase TTK | polymer | 287 | 33388.2 | 1 | UniProt (P33981) Pfam (PF00069) | Homo sapiens (Human) | Phosphotyrosine picked threonine-protein kinase,PYT |
| 2 | B (A) | N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | non-polymer | 676.7 | 1 | Chemie (SVE) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E (A) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A: 519 - 797 (UniProt: P33981)
| PDB | External Database | Details |
|---|---|---|
| Glu 511 | - | expression tag |
| Asn 512 | - | expression tag |
| Leu 513 | - | expression tag |
| Tyr 514 | - | expression tag |
| Phe 515 | - | expression tag |
| Gln 516 | - | expression tag |
| Ser 517 | - | expression tag |
| Met 518 | - | expression tag |
| Tyr 604 | Cys 604 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33388.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 800.9 | |
| All* | Total formula weight | 34189.0 |
