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Crystal structure of human PRS1 A87T mutant
Descriptor:	Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:	Chen, P, Teng, M, Li, X.
Deposit date:	2013-07-31
Release date:	2015-02-04
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (3.31 Å)
Cite:	Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One, 10, 2015

4IZY

Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
Descriptor:	C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[4-(methylsulfonyl)piperidin-1-yl]-1H-indol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
Authors:	Kuglstatter, A, Shao, A.
Deposit date:	2013-01-30
Release date:	2013-12-18
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties. Bioorg.Med.Chem.Lett., 23, 2013

4LWO

Crystal structure of PRMT6
Descriptor:	Arginine N-methyltransferase, putative
Authors:	Zhu, Y, Wang, C, Shi, Y, Teng, M.
Deposit date:	2013-07-28
Release date:	2014-02-19
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.203 Å)
Cite:	Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei Plos One, 9, 2014

4LYG

Crystal structure of human PRS1 E43T mutant
Descriptor:	Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:	Chen, P, Teng, M, Li, X.
Deposit date:	2013-07-31
Release date:	2015-02-04
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One, 10, 2015

4LZN

Crystal structure of human PRS1 D65N mutant
Descriptor:	Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:	Chen, P, Teng, M, Li, X.
Deposit date:	2013-07-31
Release date:	2015-02-04
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One, 10, 2015

4M0P

Crystal structure of human PRS1 M115T mutant
Descriptor:	Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:	Chen, P, Teng, M, Li, X.
Deposit date:	2013-08-01
Release date:	2015-02-04
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.11 Å)
Cite:	Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One, 10, 2015

5EQJ

Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae
Descriptor:	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Authors:	Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X.
Deposit date:	2015-11-13
Release date:	2016-09-14
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci Rep, 6, 2016

5ERG

Crystal structure of the two-subunit tRNA m1A58 methyltransferase TRM6-TRM61 in complex with SAM
Descriptor:	S-ADENOSYLMETHIONINE, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Authors:	Zhu, Y, Wang, M, Wang, C, Fan, X, Jiang, X, Teng, M, Li, X.
Deposit date:	2015-11-14
Release date:	2016-09-14
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.202 Å)
Cite:	Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci Rep, 6, 2016

7YCV

The Dimeric Format of Truncated PrpA (2-54)and RHH Domain of PrpA
Descriptor:	Antitoxin ParD
Authors:	Wang, C.C, Niu, C.Y, Niu, L.W.
Deposit date:	2022-07-01
Release date:	2022-09-21
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.61 Å)
Cite:	Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Front Microbiol, 13, 2022

7YCW

Crystal Form 1 of Truncated Antitoxin ParD (2-54,containg RHH domain) from Pseudoalteromonas rubra
Descriptor:	Antitoxin ParD
Authors:	Wang, C.C, Niu, C.Y, Niu, L.W.
Deposit date:	2022-07-01
Release date:	2022-09-21
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Front Microbiol, 13, 2022

7YCU

Heterotetramer of Antitoxin PrpA together with Toxin PrpT from Pseudoalteromonas rubra
Descriptor:	Antitoxin ParD, Toxin
Authors:	Wang, C.C, Niu, C.Y, Niu, L.W.
Deposit date:	2022-07-01
Release date:	2022-09-21
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Front Microbiol, 13, 2022

3GYO

Se-Met Rtt106p
Descriptor:	Histone chaperone RTT106
Authors:	Liu, Y, Huang, H, Shi, Y, Teng, M.
Deposit date:	2009-04-04
Release date:	2009-12-08
Last modified:	2021-11-10
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010

3GYP

Rtt106p
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, Histone chaperone RTT106
Authors:	Liu, Y, Huang, H, Shi, Y, Teng, M.
Deposit date:	2009-04-04
Release date:	2009-12-08
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (2.406 Å)
Cite:	Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010

4HYU

Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
Descriptor:	C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[3-(methylsulfonyl)propoxy]-1H-indazol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
Authors:	Kuglstatter, A, Ghate, M.
Deposit date:	2012-11-14
Release date:	2013-10-30
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.152 Å)
Cite:	Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. Bioorg.Med.Chem.Lett., 23, 2013

4HYS

Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan
Descriptor:	C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol
Authors:	Kuglstatter, A, Janson, C.
Deposit date:	2012-11-14
Release date:	2013-10-30
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.415 Å)
Cite:	Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. Bioorg.Med.Chem.Lett., 23, 2013

7YCS

Heterotetramer of Antitoxin PrpA together with Toxin PrpT from Pseudoalteromonas rubra
Descriptor:	Antitoxin ParD, Toxin
Authors:	Wang, C.C, Niu, L.W.
Deposit date:	2022-07-01
Release date:	2022-09-21
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Front Microbiol, 13, 2022

6JZB

Structural characterization of DnaJ from Streptococcus pneumonia presents a new tetramer of Hsp40 family
Descriptor:	Chaperone protein DnaJ, ZINC ION
Authors:	Zhu, M, Zhu, Z.L.
Deposit date:	2019-04-30
Release date:	2020-11-04
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (2.754 Å)
Cite:	Structural insights into the formation of oligomeric state by a type I Hsp40 chaperone. Biochimie, 176, 2020

4HVH

JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-hydroxy-1,2-dimethyl-propyl
Descriptor:	2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
Authors:	Kuglstatter, A, Shao, A.
Deposit date:	2012-11-06
Release date:	2013-01-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models. J.Med.Chem., 56, 2013

4I0R

Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Descriptor:	N-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase SYK
Authors:	Kuglstatter, A, Villasenor, A.G.
Deposit date:	2012-11-19
Release date:	2013-10-30
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J.Med.Chem., 56, 2013

4I0T

Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide
Descriptor:	N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase SYK
Authors:	Kuglstatter, A, Slade, M.
Deposit date:	2012-11-19
Release date:	2013-10-30
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J.Med.Chem., 56, 2013

4ICK

Crystal structure of human AP4A hydrolase E58A mutant
Descriptor:	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], GLYCEROL, MAGNESIUM ION, ...
Authors:	Ge, H, Chen, X.
Deposit date:	2012-12-10
Release date:	2013-12-11
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structure of wild-type and mutant human Ap4A hydrolase. Biochem.Biophys.Res.Commun., 432, 2013

4IJX

Crystal structure of human Ap4A hydrolase E58A mutant complexed with DPO
Descriptor:	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], DIPHOSPHATE, GLYCEROL, ...
Authors:	Ge, H, Chen, X.
Deposit date:	2012-12-24
Release date:	2013-03-20
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structure of wild-type and mutant human Ap4A hydrolase. Biochem.Biophys.Res.Commun., 432, 2013

4HVI

JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide
Descriptor:	2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
Authors:	Kuglstatter, A, Shao, A.
Deposit date:	2012-11-06
Release date:	2013-01-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models. J.Med.Chem., 56, 2013

4HVG

JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide
Descriptor:	2-cyclopropyl-N-[(2S)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
Authors:	Kuglstatter, A, Shao, A.
Deposit date:	2012-11-06
Release date:	2013-01-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models. J.Med.Chem., 56, 2013

4I0S

Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Descriptor:	2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase SYK
Authors:	Kuglstatter, A, Slade, M.
Deposit date:	2012-11-19
Release date:	2013-10-30
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J.Med.Chem., 56, 2013

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Displayed results:	25
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