7T2C
| Crystal structure of the B5 TCR in complex with HLA-DP4-Ply | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ciacchi, L, Farenc, C, Petersen, J, Reid, H.H, Rossjohn, J. | Deposit date: | 2021-12-03 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | CD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity, 56, 2023
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7T2D
| Crystal structure of the B1 TCR in complex with HLA-DP4-Ply | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DP alpha 1 chain, ... | Authors: | Ciacchi, L, Farenc, C, Petersen, J, Reid, H.H, Rossjohn, J. | Deposit date: | 2021-12-03 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | CD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity, 56, 2023
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4Y1A
| immune complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FS17_alpha, FS17_beta, ... | Authors: | Beringer, D.X, Vivian, J.P, Reid, H.H, Rossjohn, J. | Deposit date: | 2015-02-07 | Release date: | 2015-09-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nat.Immunol., 16, 2015
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4QRP
| Crystal Structure of HLA B*0801 in complex with HSKKKCDEL and DD31 TCR | Descriptor: | Beta-2-microglobulin, DD31 TCR alpha chain, DD31 TCR beta chain, ... | Authors: | Gras, S, Berry, R, Lucet, I.S, Rossjohn, J. | Deposit date: | 2014-07-02 | Release date: | 2014-11-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant. J.Immunol., 193, 2014
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6MWR
| Recognition of MHC-like molecule | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | Authors: | Le Nours, J, Rossjohn, J. | Deposit date: | 2018-10-30 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1. Science, 366, 2019
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4QRQ
| Crystal Structure of HLA B*0801 in complex with HSKKKCDEL | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | Authors: | Gras, S, Berry, R, Lucet, I.S, Rossjohn, J. | Deposit date: | 2014-07-02 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant. J.Immunol., 193, 2014
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5D7J
| Structure of human MR1-5-OP-RU in complex with human MAIT M33.64(Y95alphaF) TCR | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Keller, A.N, Woolley, R.E, Rossjohn, J. | Deposit date: | 2015-08-14 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 44, 2016
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5D7I
| Structure of human MR1-Ac-6-FP in complex with human MAIT M33.64 TCR | Descriptor: | Beta-2-microglobulin, GLYCEROL, M33.64 TCR Alpha Chain, ... | Authors: | Keller, A.N, Woolley, R.E, Rossjohn, J. | Deposit date: | 2015-08-14 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 44, 2016
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5D5M
| Structure of human MR1-5-OP-RU in complex with human MAIT M33.64 TCR | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, ACETATE ION, Beta-2-microglobulin, ... | Authors: | Keller, A.N, Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2015-08-11 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 44, 2016
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5D7L
| Structure of human MR1-5-OP-RU in complex with human MAV36 TCR | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, MAV36 TCR Alpha Chain, ... | Authors: | Keller, A.N, Rossjohn, J. | Deposit date: | 2015-08-14 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 44, 2016
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4Z7U
| S13 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ... | Authors: | Petersen, J, Rossjohn, J, Reid, H.H, Koning, F. | Deposit date: | 2015-04-08 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Determinants of Gliadin-Specific T Cell Selection in Celiac Disease. J Immunol., 194, 2015
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4Z7W
| T316 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DQ8-glia-alpha1, MHC class II HLA-DQ-alpha chain, ... | Authors: | Petersen, J, Rossjohn, J, Reid, H.H, Koning, F. | Deposit date: | 2015-04-08 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Determinants of Gliadin-Specific T Cell Selection in Celiac Disease. J Immunol., 194, 2015
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5D7K
| Structure of MR1-reactive MAV36 TCR | Descriptor: | MAV36 TCR Alpha Chain, MAV36 TCR Beta Chain, SULFATE ION | Authors: | Keller, A.N, Rossjohn, J. | Deposit date: | 2015-08-14 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 44, 2016
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4Z7V
| L3-12 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ... | Authors: | Petersen, J, Rossjohn, J, Reid, H.H, Koning, F. | Deposit date: | 2015-04-08 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Determinants of Gliadin-Specific T Cell Selection in Celiac Disease. J Immunol., 194, 2015
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8VZ9
| Crystal structure of mouse MAIT M2A TCR-MR1-5-OP-RU complex | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Ciacchi, L, Rossjohn, J, Awad, W. | Deposit date: | 2024-02-11 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil. J.Biol.Chem., 300, 2024
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8VZ8
| Crystal structure of mouse MAIT M2B TCR-MR1-5-OP-RU complex | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Ciacchi, L, Rossjohn, J, Awad, W. | Deposit date: | 2024-02-11 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil. J.Biol.Chem., 300, 2024
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6PA1
| Killer cell immunoglobulin-like receptor 2DL2 in complex with HLA-C*07:02 | Descriptor: | ARG-TYR-ARG-PRO-GLY-THR-VAL-ALA-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Moradi, S, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-06-11 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nat Commun, 12, 2021
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6PAG
| Killer cell immunoglobulin-like receptor 2DL3 in complex with HLA-C*07:02 | Descriptor: | ARG-TYR-ARG-PRO-GLY-THR-VAL-ALA-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Moradi, S, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-06-11 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nat Commun, 12, 2021
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6PX6
| HLA-TCR complex | Descriptor: | DQ2.2-glut-L1, HLA class II histocompatibility antigen DQ alpha chain, HLA class II histocompatibility antigen DQ beta chain, ... | Authors: | Ting, Y.T, Reid, H.H, Rossjohn, J. | Deposit date: | 2019-07-24 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.00000334 Å) | Cite: | A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease. Proc.Natl.Acad.Sci.USA, 117, 2020
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6X00
| Structure of DbNA(11) peptides bound to H-2Db MHC-I | Descriptor: | Beta-2-microglobulin, Epitope from Neuraminidase Protein (NA-181-191), H-2 class I histocompatibility antigen, ... | Authors: | Farenc, C, Rossjohn, J. | Deposit date: | 2020-05-14 | Release date: | 2020-09-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Overlapping Peptides Elicit Distinct CD8 + T Cell Responses following Influenza A Virus Infection. J Immunol., 205, 2020
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6OVN
| Crystal structure of the unliganded Clone 2 TCR | Descriptor: | Alpha chain Clone 2 TCR, Beta chain Clone 2 TCR, CHLORIDE ION, ... | Authors: | Shahine, A, Rossjohn, J. | Deposit date: | 2019-05-08 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | A TCR beta-Chain Motif Biases toward Recognition of Human CD1 Proteins. J Immunol., 203, 2019
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5G2N
| X-ray structure of PI3Kinase Gamma in complex with Copanlisib | Descriptor: | 2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION | Authors: | Schaefer, M, Scott, W.J, Hentemann, M.F, Rowley, R.B, Bull, C.O, Jenkins, S, Bullion, A.M, Johnson, J, Redman, A, Robbins, A.H, Esler, W, Fracasso, R.P, Garrison, T, Hamilton, M, Michels, M, Wood, J.E, Wilkie, D.P, Xiao, H, Levy, J, Liu, N, Stasik, E, Brands, M, Lefranc, J. | Deposit date: | 2016-04-11 | Release date: | 2016-04-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Discovery and Sar of Novel 2,3-Dihydroimidazo(1,2-C)Quinazoline Pi3K Inhibitors: Identification of Copanlisib (Bay 80-6946) Chemmedchem, 11, 2016
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3AJA
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6MSS
| Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies | Descriptor: | (2S)-2-(heptadecanoyloxy)-3-{[(10S)-10-methyloctadecanoyl]oxy}propyl alpha-D-glucopyranosiduronic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sundararaj, S, Le Nours, J, Praveena, T, Rossjohn, J. | Deposit date: | 2018-10-18 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nat Commun, 10, 2019
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6MRA
| Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies | Descriptor: | TCR alpha chain, TCR beta-chain | Authors: | Sundararaj, S, Le Nours, J, Praveena, T, Rossjohn, J. | Deposit date: | 2018-10-12 | Release date: | 2019-09-18 | Last modified: | 2020-01-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nat Commun, 10, 2019
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