7Z9W
 
 | | BRD4 in complex with FragLite1 | | Descriptor: | 4-bromo-1H-pyrazole, GLYCEROL, Isoform C of Bromodomain-containing protein 4 | | Authors: | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | | Deposit date: | 2022-03-21 | | Release date: | 2022-12-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (0.988 Å) | | Cite: | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
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7ZA8
 | | BRD4 in complex with FragLite6 | | Descriptor: | 4-bromanyl-1~{H}-pyridin-2-one, Isoform C of Bromodomain-containing protein 4 | | Authors: | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | | Deposit date: | 2022-03-22 | | Release date: | 2022-12-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
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7ZPC
 | | CDK2 in complex 9K-DOS | | Descriptor: | Cyclin-dependent kinase 2, ~{N}-(1-methylpyrazol-4-yl)-5-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxamide | | Authors: | Watt, J.E, Martin, M.P, Noble, M.E.N. | | Deposit date: | 2022-04-27 | | Release date: | 2023-02-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity.
J.Med.Chem., 65, 2022
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9ET3
 | | CDK2-cyclin A in complex with FragLite 10 | | Descriptor: | 6-bromo-1,3-dihydro-2H-indol-2-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESP
 | | CDK2-cyclin A in complex with FragLite 26 | | Descriptor: | 4-bromo-1-(2-methoxyethyl)-1H-pyrazole, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.381 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET4
 | | CDK2-cyclin A in complex with FragLite 9 | | Descriptor: | 4-iodanylbenzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.641 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESO
 | | CDK2-cyclin A in complex with FragLite 27 | | Descriptor: | (4-bromo-1H-pyrazol-1-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET1
 | | CDK2-cyclin A in complex with FragLite 12 | | Descriptor: | 4-iodanylbenzamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESJ
 | | CDK2-cyclin A in complex with FragLite 31 | | Descriptor: | 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESQ
 | | CDK2-cyclin A in complex with FragLite 24 | | Descriptor: | 4-bromanyl-2-oxidanyl-benzoic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESZ
 | | CDK2-cyclin A in complex with FragLite 14 | | Descriptor: | 5-iodanylpyrimidine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET5
 | | CDK2-cyclin A in complex with FragLite 8 | | Descriptor: | 4-bromobenzene-1-sulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ETA
 | | CDK2-cyclin A in complex with FragLite 3 | | Descriptor: | 4-bromanyl-1,2-oxazole, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.512 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESY
 | | CDK2-cyclin A in complex with FragLite 16 | | Descriptor: | 4-bromanyl-1,8-naphthyridine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ETB
 | | CDK2-cyclin A in complex with FragLite 2 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-IODOPYRAZOLE, Cyclin-A2, ... | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESN
 | | CDK2-cyclin A in complex with FragLite 28 | | Descriptor: | 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.393 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESU
 | | CDK2-cyclin A in complex with FragLite 20 | | Descriptor: | 4-bromanyl-2-(methoxymethyl)pyridine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET7
 | | CDK2-cyclin A in complex with FragLite 6 | | Descriptor: | 4-bromanyl-1~{H}-pyridin-2-one, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ETP
 | | CDK2-cyclin A in complex with FragLite 1 | | Descriptor: | 4-bromo-1H-pyrazole, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESX
 | | CDK2-cyclin A in complex with FragLite 17 | | Descriptor: | 1-bromanyl-4-methylsulfonyl-benzene, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET9
 | | CDK2-cyclin A in complex with FragLite 4 | | Descriptor: | 4-bromanylpyridin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.494 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESK
 | | CDK2-cyclin A in complex with FragLite 30 | | Descriptor: | (4-bromo-2-oxopyridin-1(2H)-yl)acetic acid, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ESW
 | | CDK2-cyclin A in complex with FragLite 18 | | Descriptor: | (4-bromanylpyridin-2-yl)methanol, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET8
 | | CDK2-cyclin A in complex with FragLite 5 | | Descriptor: | 4-iodanylpyridin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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9ET2
 | | CDK2-cyclin A in complex with FragLite 11 | | Descriptor: | Cyclin-A2, Cyclin-dependent kinase 2, ~{N}-(4-bromophenyl)ethanamide | | Authors: | Hope, I, Martin, M.P, Waring, M.J, Noble, M.E.M, Endicott, J.A, Tatum, N.J. | | Deposit date: | 2024-03-26 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction
To Be Published
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