3EB1
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![BU of 3eb1 by Molmil](/molmil-images/mine/3eb1) | Crystal structure PTP1B complex with small molecule inhibitor LZP-25 | Descriptor: | 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Liu, S, Zheng, L.-F, Wu, L, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q, Zhang, Z.-Y. | Deposit date: | 2008-08-26 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J.Am.Chem.Soc., 130, 2008
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7ARM
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![BU of 7arm by Molmil](/molmil-images/mine/7arm) | LolCDE in complex with lipoprotein and LolA | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Shen, C.R, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Wei, X.W, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARL
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![BU of 7arl by Molmil](/molmil-images/mine/7arl) | LolCDE in complex with lipoprotein and ADP | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, ADENOSINE-5'-DIPHOSPHATE, LPP, ... | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Shen, C.R, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Wei, X.W, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARK
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![BU of 7ark by Molmil](/molmil-images/mine/7ark) | LolCDE in complex with AMP-PNP in the closed NBD state | Descriptor: | Lipoprotein-releasing ABC transporter permease subunit LolC, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolE, ... | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARJ
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![BU of 7arj by Molmil](/molmil-images/mine/7arj) | LolCDE in complex with lipoprotein and AMPPNP complex undimerized form | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARI
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![BU of 7ari by Molmil](/molmil-images/mine/7ari) | LolCDE apo structure | Descriptor: | Lipoprotein-releasing ABC transporter permease subunit LolC, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolE | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARH
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![BU of 7arh by Molmil](/molmil-images/mine/7arh) | LolCDE in complex with lipoprotein | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | Authors: | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | Deposit date: | 2020-10-25 | Release date: | 2021-04-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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2FH7
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![BU of 2fh7 by Molmil](/molmil-images/mine/2fh7) | Crystal structure of the phosphatase domains of human PTP SIGMA | Descriptor: | Receptor-type tyrosine-protein phosphatase S | Authors: | Alvarado, J, Udupi, R, Smith, D, Koss, J, Wasserman, S.R, Ozyurt, S, Atwell, S, Powell, A, Kearins, M.C, Rooney, I, Maletic, M, Bain, K.T, Freeman, J.C, Russell, M, Thompson, D.A, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2005-12-23 | Release date: | 2006-01-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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8SKL
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![BU of 8skl by Molmil](/molmil-images/mine/8skl) | PTP1B in complex with 182 | Descriptor: | 1,2-ETHANEDIOL, 5-[1-fluoro-3-hydroxy-7-(3-hydroxy-3-methylbutoxy)naphthalen-2-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, ... | Authors: | Babon, J.J, Chen, H, Tiganis, T. | Deposit date: | 2023-04-20 | Release date: | 2023-08-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14, 2023
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2H31
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![BU of 2h31 by Molmil](/molmil-images/mine/2h31) | Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine biosynthesis | Descriptor: | CARBON DIOXIDE, Multifunctional protein ADE2 | Authors: | Li, S.-X, Tong, Y.-P, Xie, X.-C, Li, S.-G, Bi, R.-C. | Deposit date: | 2006-05-21 | Release date: | 2007-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis. J.Mol.Biol., 366, 2007
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3RZ2
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![BU of 3rz2 by Molmil](/molmil-images/mine/3rz2) | Crystal of Prl-1 complexed with peptide | Descriptor: | Prl-1 (PTP4A1), Protein tyrosine phosphatase type IVA 1 | Authors: | Zhang, Z.-Y, Liu, D, Bai, Y. | Deposit date: | 2011-05-11 | Release date: | 2011-10-26 | Last modified: | 2014-10-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. J.Biol.Chem., 286, 2011
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6KZQ
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![BU of 6kzq by Molmil](/molmil-images/mine/6kzq) | structure of PTP-MEG2 and NSF-pY83 peptide complex | Descriptor: | NSF-pY83 peptide, Tyrosine-protein phosphatase non-receptor type 9 | Authors: | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | Deposit date: | 2019-09-25 | Release date: | 2020-09-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep., 22, 2021
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6L03
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![BU of 6l03 by Molmil](/molmil-images/mine/6l03) | structure of PTP-MEG2 and MUNC18-1-pY145 peptide complex | Descriptor: | Tyrosine-protein phosphatase non-receptor type 9, stxbp1-pY145 peptide | Authors: | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | Deposit date: | 2019-09-25 | Release date: | 2020-09-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.084 Å) | Cite: | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep., 22, 2021
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2NV5
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![BU of 2nv5 by Molmil](/molmil-images/mine/2nv5) | Crystal structure of a C-terminal phosphatase domain of Rattus norvegicus ortholog of human protein tyrosine phosphatase, receptor type, D (PTPRD) | Descriptor: | PTPRD, PHOSPHATASE | Authors: | Bonanno, J.B, Gilmore, J, Bain, K.T, Iizuka, M, Xu, W, Wasserman, S, Smith, D, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-11-10 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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2P4U
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![BU of 2p4u by Molmil](/molmil-images/mine/2p4u) | Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus | Descriptor: | Acid phosphatase 1, PHOSPHATE ION | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Wu, B, Xu, W, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-03-13 | Release date: | 2007-03-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2PBN
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![BU of 2pbn by Molmil](/molmil-images/mine/2pbn) | Crystal structure of the human tyrosine receptor phosphate gamma | Descriptor: | Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Reyes, C, Pelletier, L, Jin, X, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-03-28 | Release date: | 2007-04-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2P27
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![BU of 2p27 by Molmil](/molmil-images/mine/2p27) | Crystal Structure of Human Pyridoxal Phosphate Phosphatase with Mg2+ at 1.9 A resolution | Descriptor: | MAGNESIUM ION, Pyridoxal phosphate phosphatase | Authors: | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-03-07 | Release date: | 2007-03-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2OYC
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![BU of 2oyc by Molmil](/molmil-images/mine/2oyc) | Crystal structure of human pyridoxal phosphate phosphatase | Descriptor: | Pyridoxal phosphate phosphatase, SODIUM ION, TUNGSTATE(VI)ION | Authors: | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-02-21 | Release date: | 2007-03-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2P69
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![BU of 2p69 by Molmil](/molmil-images/mine/2p69) | Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP | Descriptor: | CALCIUM ION, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate phosphatase | Authors: | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-03-16 | Release date: | 2007-04-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2Q5E
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![BU of 2q5e by Molmil](/molmil-images/mine/2q5e) | Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 | Descriptor: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, MAGNESIUM ION | Authors: | Bonanno, J.B, Dickey, M, Bain, K.T, Lau, C, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-05-31 | Release date: | 2007-06-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2P8E
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![BU of 2p8e by Molmil](/molmil-images/mine/2p8e) | Crystal structure of the serine/threonine phosphatase domain of human PPM1B | Descriptor: | MAGNESIUM ION, PPM1B beta isoform variant 6 | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Lau, C, Xu, W, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-03-22 | Release date: | 2007-04-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.816 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2R0B
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![BU of 2r0b by Molmil](/molmil-images/mine/2r0b) | Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine/tyrosine-interacting protein | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Iizuka, M, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-08-18 | Release date: | 2007-08-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2ISN
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![BU of 2isn by Molmil](/molmil-images/mine/2isn) | Crystal structure of a phosphatase from a pathogenic strain Toxoplasma gondii | Descriptor: | NYSGXRC-8828z, phosphatase, PRASEODYMIUM ION, ... | Authors: | Agarwal, R, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-10-18 | Release date: | 2006-10-31 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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2IRM
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![BU of 2irm by Molmil](/molmil-images/mine/2irm) | Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae | Descriptor: | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 | Authors: | Jin, X, Bonanno, J.B, Pelletier, L, Freeman, J.C, Wasserman, S, Sauder, J.M, Burley, S.K, Shapiro, L, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-10-15 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM., 8, 2007
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2IQ1
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![BU of 2iq1 by Molmil](/molmil-images/mine/2iq1) | Crystal structure of human PPM1K | Descriptor: | MAGNESIUM ION, Protein phosphatase 2C kappa, PPM1K | Authors: | Bonanno, J.B, Freeman, J, Russell, M, Bain, K.T, Adams, J, Pelletier, L, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-10-12 | Release date: | 2006-11-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural genomics of protein phosphatases J.STRUCT.FUNCT.GENOM., 8, 2007
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