8SKL
PTP1B in complex with 182
Summary for 8SKL
Entry DOI | 10.2210/pdb8skl/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, CHLORIDE ION, SODIUM ION, ... (6 entities in total) |
Functional Keywords | phosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38193.29 |
Authors | Babon, J.J.,Chen, H.,Tiganis, T. (deposition date: 2023-04-20, release date: 2023-08-02, Last modification date: 2023-08-16) |
Primary citation | Liang, S.,Tran, E.,Du, X.,Dong, J.,Sudholz, H.,Chen, H.,Qu, Z.,Huntington, N.D.,Babon, J.J.,Kershaw, N.J.,Zhang, Z.Y.,Baell, J.B.,Wiede, F.,Tiganis, T. A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14:4524-4524, 2023 Cited by PubMed: 37500611DOI: 10.1038/s41467-023-40170-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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