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HUMAN MANGANESE SUPEROXIDE DISMUTASE MUTANT Q143N
Descriptor:	MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE
Authors:	Guan, Y, Tainer, J.A.
Deposit date:	1997-07-03
Release date:	1998-01-07
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Probing the active site of human manganese superoxide dismutase: the role of glutamine 143. Biochemistry, 37, 1998

3GZ0

Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
Descriptor:	Carbonic anhydrase 2, ZINC ION
Authors:	Avvaru, B.S, McKenna, R.
Deposit date:	2009-04-06
Release date:	2009-07-21
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.26 Å)
Cite:	Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability, and Solvent Network . Biochemistry, 48, 2009

4G0C

Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
Descriptor:	5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:	Fisher, S.Z, McKenna, R, Aggarwal, M.
Deposit date:	2012-07-09
Release date:	2012-09-19
Last modified:	2023-09-13
Method:	NEUTRON DIFFRACTION (2 Å)
Cite:	Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. J.Am.Chem.Soc., 134, 2012

4GL1

Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
Descriptor:	Carbonic anhydrase 2, ZINC ION
Authors:	West, D.M.
Deposit date:	2012-08-13
Release date:	2013-09-04
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Hydrophobicity and low pKa impact catalytic efficiency of Human Carbonic Anhydrases To be Published

4HEY

Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor:	4-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:	Aggarwal, M, McKenna, R.
Deposit date:	2012-10-04
Release date:	2013-10-23
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014

4HEW

Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor:	2-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:	Aggarwal, M, McKenna, R.
Deposit date:	2012-10-04
Release date:	2013-10-23
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.6984 Å)
Cite:	Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014

4HBA

Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
Descriptor:	Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:	Boone, C.D, Habibzadegan, A, McKenna, R.
Deposit date:	2012-09-27
Release date:	2013-07-31
Last modified:	2017-11-15
Method:	X-RAY DIFFRACTION (1.762 Å)
Cite:	Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond. Acta Crystallogr.,Sect.D, 69, 2013

4HF3

Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor:	Carbonic anhydrase 2, IMIDAZOLE, ZINC ION
Authors:	Aggarwal, M, McKenna, R.
Deposit date:	2012-10-04
Release date:	2013-10-23
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.1476 Å)
Cite:	Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014

4HEZ

Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
Descriptor:	1-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
Authors:	Aggarwal, M, McKenna, R.
Deposit date:	2012-10-04
Release date:	2013-10-23
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.3446 Å)
Cite:	Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014

4IDR

Human Carbonic Anhydrase II Proton Transfer Double Mutant
Descriptor:	Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:	Mikulski, R.M, West, D.M.
Deposit date:	2012-12-13
Release date:	2012-12-26
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013

2NWP

Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor:	SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-16
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2NXS

Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor:	SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-19
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2NWY

Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor:	ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-16
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2NWZ

Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor:	SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-16
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2NXR

Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor:	SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-19
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2OSM

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Descriptor:	2-MERCAPTOPHENOL, Carbonic anhydrase 2, ZINC ION
Authors:	Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-Mckenna, M, McKenna, R, Tripp, B.C.
Deposit date:	2007-02-06
Release date:	2008-02-12
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study. Biochemistry, 47, 2008

2NXT

Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor:	ZINC ION, carbonic anhydrase 2
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-19
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.15 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

2P4K

Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase
Descriptor:	MANGANESE (II) ION, Superoxide dismutase
Authors:	Perry, J.J.
Deposit date:	2007-03-12
Release date:	2007-04-03
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.48 Å)
Cite:	Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry, 48, 2009

2OSF

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Descriptor:	4-MERCAPTOBENZENE-1,3-DIOL, Carbonic anhydrase 2, S-(2,4-dihydroxyphenyl) hydrogen thiocarbonate, ...
Authors:	Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-McKenna, M, McKenna, R, Tripp, B.C.
Deposit date:	2007-02-05
Release date:	2008-05-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry, 47, 2008

2NWO

Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, ZINC ION
Authors:	Fisher, S.Z, McKenna, R.
Deposit date:	2006-11-16
Release date:	2007-04-24
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007

4L5V

The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:	Boone, C.D, Gill, S, McKenna, R.
Deposit date:	2013-06-11
Release date:	2014-04-30
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.63 Å)
Cite:	Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II. Arch.Biochem.Biophys., 539, 2013

4L5W

Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:	Boone, C.D, Gill, S, McKenna, R.
Deposit date:	2013-06-11
Release date:	2014-04-30
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II. Arch.Biochem.Biophys., 539, 2013

4L5U

The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, GLYCEROL, ZINC ION
Authors:	Boone, C.D, Gill, S, McKenna, R.
Deposit date:	2013-06-11
Release date:	2014-04-30
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II. Arch.Biochem.Biophys., 539, 2013

3RG3

Crystal structure of the W5E mutant of human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, ZINC ION
Authors:	Domsic, J.F, Robbins, A.H, McKenna, R.
Deposit date:	2011-04-07
Release date:	2012-02-22
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.903 Å)
Cite:	Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5. Arch.Biochem.Biophys., 516, 2011

3RGE

Crystal structure of the W5H mutant of human carbonic anhydrase II
Descriptor:	Carbonic anhydrase 2, ZINC ION
Authors:	Domsic, J.F, Robbins, A.H, McKenna, R.
Deposit date:	2011-04-08
Release date:	2012-02-22
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.096 Å)
Cite:	Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5. Arch.Biochem.Biophys., 516, 2011

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