2L7K
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![BU of 2l7k by Molmil](/molmil-images/mine/2l7k) | Solution NMR Structure of protein CD1104.2 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 | Descriptor: | Uncharacterized protein | Authors: | Pulavarti, S.V.S.R.K, Eletsky, A, Mills, J.L, Sukumaran, D.K, Wang, H, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-12-13 | Release date: | 2011-02-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of CfR130 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 To be Published
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2L33
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![BU of 2l33 by Molmil](/molmil-images/mine/2l33) | Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E | Descriptor: | Interleukin enhancer-binding factor 3 | Authors: | Liu, G, Janjua, H, Xiao, R, Acton, T.B, Ciccosanti, A, Shastry, R.B, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-09-03 | Release date: | 2010-09-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target HR4527E To be Published
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2LMD
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![BU of 2lmd by Molmil](/molmil-images/mine/2lmd) | Minimal Constraints Solution NMR Structure of Prospero Homeobox protein 1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4660B | Descriptor: | Prospero homeobox protein 1 | Authors: | Rossi, P, Lange, O.A, Lee, H, Maglaqui, M, Janjua, H, Ciccosanti, C, Zhao, L, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-11-29 | Release date: | 2011-12-21 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples. Proc.Natl.Acad.Sci.USA, 109, 2012
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2LFH
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![BU of 2lfh by Molmil](/molmil-images/mine/2lfh) | Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A | Descriptor: | DNA-binding protein inhibitor ID-3 | Authors: | Eletsky, A, Wang, D, Kohan, E, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-06-30 | Release date: | 2011-07-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A To be Published
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2L8V
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![BU of 2l8v by Molmil](/molmil-images/mine/2l8v) | Solution NMR structure of the phycobilisome linker polypeptide domain of CpcC (20-153) from Thermosynechococcus elongatus, Northeast Structural Genomics Consortium Target TeR219A | Descriptor: | Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod | Authors: | Ramelot, T.A, Yang, Y, Cort, J.R, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-01-26 | Release date: | 2011-02-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the phycobilisome linker polypeptide domain of CpcC
(20-153) from Thermosynechococcus elongatus, Northeast Structural Genomics
Consortium Target TeR219A To be Published
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2KZV
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![BU of 2kzv by Molmil](/molmil-images/mine/2kzv) | Solution NMR structure of CV_0373(175-257) protein from Chromobacterium violaceum, Northeast Structural Genomics Consortium Target CvR118A | Descriptor: | Uncharacterized protein | Authors: | Yang, Y, Ramelot, T.A, Wang, D, Ciccosanti, C, Mao, L, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-25 | Release date: | 2010-08-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of CV_0373(175-257) protein from Chromobacterium violaceum, Northeast Structural Genomics Consortium Target CvR118A. To be Published
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7L48
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![BU of 7l48 by Molmil](/molmil-images/mine/7l48) | Cryo-EM structure of a CRISPR-Cas12f Binary Complex | Descriptor: | Cas12f, ZINC ION, sgRNA | Authors: | Chang, L, Li, Z. | Deposit date: | 2020-12-18 | Release date: | 2021-06-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease. Nucleic Acids Res., 49, 2021
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7L49
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![BU of 7l49 by Molmil](/molmil-images/mine/7l49) | Cryo-EM structure of CRISPR-Cas12f Ternary Complex | Descriptor: | Cas12f1, NTS, Substrate, ... | Authors: | Chang, L, Li, Z. | Deposit date: | 2020-12-18 | Release date: | 2021-06-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease. Nucleic Acids Res., 49, 2021
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8HB9
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![BU of 8hb9 by Molmil](/molmil-images/mine/8hb9) | Crystal Structure of Human IDH1 R132H Mutant in Complex with NADPH and Compound IHMT-IDH1-053 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | Authors: | Guo, G, Wang, B, Liu, J, Liu, Q. | Deposit date: | 2022-10-27 | Release date: | 2023-05-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor. Eur.J.Med.Chem., 256, 2023
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8H4I
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![BU of 8h4i by Molmil](/molmil-images/mine/8h4i) | DHA-bound FFAR4 in complex with Gs | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4L
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![BU of 8h4l by Molmil](/molmil-images/mine/8h4l) | DHA-bound FFAR4 in complex with Gq | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4K
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![BU of 8h4k by Molmil](/molmil-images/mine/8h4k) | GW9508-bound FFAR4 in complex with Gq | Descriptor: | 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8WW2
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![BU of 8ww2 by Molmil](/molmil-images/mine/8ww2) | GPR3/Gs complex | Descriptor: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Xiong, Y. | Deposit date: | 2023-10-24 | Release date: | 2024-02-14 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
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8GN6
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![BU of 8gn6 by Molmil](/molmil-images/mine/8gn6) | Crystallization of Sialidase from Porphyromonas gingivalis | Descriptor: | Sialidase, UNKNOWN LIGAND | Authors: | Dong, W.B. | Deposit date: | 2022-08-23 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and enzymatic characterization of the sialidase SiaPG from Porphyromonas gingivalis. Acta Crystallogr.,Sect.F, 79, 2023
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7YUB
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![BU of 7yub by Molmil](/molmil-images/mine/7yub) | S1P-bound human SPNS2 | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, NbFab-H-chain, NbFab-L-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUF
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![BU of 7yuf by Molmil](/molmil-images/mine/7yuf) | apo human SPNS2 | Descriptor: | NbFab H-chain, NbFab L-chain, Sphingosine-1-phosphate transporter SPNS2, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUD
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![BU of 7yud by Molmil](/molmil-images/mine/7yud) | FTY720p-bound human SPNS2 | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, NbFab L-chain, NbFab-H-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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2R7D
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![BU of 2r7d by Molmil](/molmil-images/mine/2r7d) | Crystal structure of ribonuclease II family protein from Deinococcus radiodurans, triclinic crystal form. NorthEast Structural Genomics target DrR63 | Descriptor: | MAGNESIUM ION, Ribonuclease II family protein | Authors: | Seetharaman, J, Neely, H, Forouhar, F, Wang, D, Fang, Y, Cunningham, K, Ma, L.-C, Xia, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-09-07 | Release date: | 2007-10-02 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure and Enzymatic Properties of a Novel RNase II Family Enzyme from Deinococcus radiodurans. J.Mol.Biol., 415, 2012
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8KAE
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![BU of 8kae by Molmil](/molmil-images/mine/8kae) | 16d-bound human SPNS2 | Descriptor: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, NbFab chain L, NbFab-H chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2023-08-03 | Release date: | 2024-01-03 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YDP
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![BU of 7ydp by Molmil](/molmil-images/mine/7ydp) | Cryo-EM structure of CD97/miniGs complex | Descriptor: | Adhesion G protein-coupled receptor E5 subunit beta, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Wang, N. | Deposit date: | 2022-07-04 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of CD97 activation and G-protein coupling. Cell Chem Biol, 30, 2023
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7YDM
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![BU of 7ydm by Molmil](/molmil-images/mine/7ydm) | Cryo-EM structure of CD97/Gq complex | Descriptor: | Adhesion G protein-coupled receptor E5 subunit beta, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Wang, N. | Deposit date: | 2022-07-04 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural basis of CD97 activation and G-protein coupling. Cell Chem Biol, 30, 2023
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7YDH
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![BU of 7ydh by Molmil](/molmil-images/mine/7ydh) | Cryo EM structure of CD97/miniG13 complex | Descriptor: | Adhesion G protein-coupled receptor E5 subunit beta, G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Wang, N. | Deposit date: | 2022-07-04 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of CD97 activation and G-protein coupling. Cell Chem Biol, 30, 2023
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8IYS
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![BU of 8iys by Molmil](/molmil-images/mine/8iys) | TUG891-bound FFAR4 in complex with Gq | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2023-04-06 | Release date: | 2023-06-21 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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7EO2
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![BU of 7eo2 by Molmil](/molmil-images/mine/7eo2) | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Xu, Z, Ikuta, T. | Deposit date: | 2021-04-21 | Release date: | 2022-01-05 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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7EO4
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![BU of 7eo4 by Molmil](/molmil-images/mine/7eo4) | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312 | Descriptor: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Xu, Z, Ikuta, T, Inoue, A. | Deposit date: | 2021-04-21 | Release date: | 2022-01-05 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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