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7RU5
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BU of 7ru5 by Molmil
CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC6.30 Fab heavy chain Fv, ...
Authors:Ozorowski, G, Turner, H.L, Ward, A.B.
Deposit date:2021-08-16
Release date:2022-08-24
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways.
Iscience, 25, 2022
8SF6
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BU of 8sf6 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in closed conformation
Descriptor: 2-(2-ETHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Buller, A.R, Zmich, A.P, Bingman, C.A.
Deposit date:2023-04-10
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
8SF5
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BU of 8sf5 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in open conformation
Descriptor: O-acetylhomoserine/O-acetylserine sulfhydrylase
Authors:Buller, A.R, Zmich, A.P, Bingman, C.A.
Deposit date:2023-04-10
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
6FKS
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BU of 6fks by Molmil
Crystal structure of a dye-decolorizing peroxidase from Klebsiella pneumoniae (KpDyP)
Descriptor: GLYCEROL, Iron-dependent peroxidase, MAGNESIUM ION, ...
Authors:Pfanzagl, V, Hofbauer, S, Mlynek, G.
Deposit date:2018-01-24
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.60000467 Å)
Cite:Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage.
J. Biol. Chem., 293, 2018
6FL2
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BU of 6fl2 by Molmil
Crystal structure of a dye-decolorizing peroxidase D143A variant from Klebsiella pneumoniae (KpDyP)
Descriptor: GLYCEROL, Iron-dependent peroxidase, MAGNESIUM ION, ...
Authors:Pfanzagl, V, Hofbauer, S, Mlynek, G.
Deposit date:2018-01-25
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.270001 Å)
Cite:Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage.
J. Biol. Chem., 293, 2018
7WEU
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BU of 7weu by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-048
Descriptor: Peroxiredoxin-1, UNKNOWN LIGAND
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
7WET
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BU of 7wet by Molmil
Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela
Descriptor: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
6FIY
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BU of 6fiy by Molmil
Crystal structure of a dye-decolorizing peroxidase D143AR232A variant from Klebsiella pneumoniae (KpDyP)
Descriptor: GLYCEROL, Iron-dependent peroxidase, MAGNESIUM ION, ...
Authors:Pfanzagl, V, Hofbauer, S, Mlynek, G.
Deposit date:2018-01-19
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.09000432 Å)
Cite:Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage.
J. Biol. Chem., 293, 2018
6FKT
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BU of 6fkt by Molmil
Crystal structure of a dye-decolorizing peroxidase R232A variant from Klebsiella pneumoniae (KpDyP)
Descriptor: Iron-dependent peroxidase, MAGNESIUM ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Pfanzagl, V, Hofbauer, S, Mlynek, G.
Deposit date:2018-01-24
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.86002779 Å)
Cite:Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage.
J. Biol. Chem., 293, 2018
6FY5
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BU of 6fy5 by Molmil
Crystal structure of the macro domain of human macroh2a2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Core histone macro-H2A.2
Authors:Hothorn, M.
Deposit date:2018-03-10
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.
EMBO Rep., 19, 2018
7KXL
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BU of 7kxl by Molmil
BTK1 SOAKED WITH COMPOUND 5, Y551 IS SEQUESTERED
Descriptor: 3-tert-butyl-N-({2-fluoro-4-[2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK
Authors:Gardberg, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXO
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BU of 7kxo by Molmil
BTK1 SOAKED WITH COMPOUND 24
Descriptor: 3-tert-butyl-N-[(1R)-6-{2-[5-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXP
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BU of 7kxp by Molmil
BTK1 SOAKED WITH COMPOUND 25
Descriptor: 3-tert-butyl-N-[(1S)-6-{2-[3-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXN
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BU of 7kxn by Molmil
BTK1 SOAKED WITH COMPOUND 26
Descriptor: 3-tert-butyl-N-[(1S)-6-{2-[5-methyl-1-(propan-2-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXM
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BU of 7kxm by Molmil
BTK1 SOAKED WITH COMPOUND 5, Y551 IS SEQUESTERED
Descriptor: 4-tert-butyl-N-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide, Tyrosine-protein kinase BTK
Authors:Gardberg, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXQ
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BU of 7kxq by Molmil
BTK1 SOAKED WITH COMPOUND 30
Descriptor: 3-tert-butyl-N-[(5R)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1H-pyrazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
5CES
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BU of 5ces by Molmil
C-terminal domain of the R-type pyocin baseplate protein PA0618
Descriptor: PA0618
Authors:Plattner, M, Buth, S.A, Shneider, M.M, Leiman, P.G.
Deposit date:2015-07-07
Release date:2016-07-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Action of a minimal contractile bactericidal nanomachine.
Nature, 580, 2020
1ODU
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BU of 1odu by Molmil
CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE IN COMPLEX WITH FUCOSE
Descriptor: PUTATIVE ALPHA-L-FUCOSIDASE, beta-L-fucopyranose
Authors:Sulzenbacher, G, Bignon, C, Bourne, Y, Henrissat, B.
Deposit date:2003-03-14
Release date:2004-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Thermotoga Maritima {Alpha}-L-Fucosidase: Insights Into the Catalytic Mechanism and the Molecular Basis for Fucosidosis
J.Biol.Chem., 279, 2004
4COS
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BU of 4cos by Molmil
Crystal structure of the PHD-Bromo-PWWP cassette of human PRKCBP1
Descriptor: 1,4-DIETHYLENE DIOXIDE, PROTEIN KINASE C-BINDING PROTEIN 1, ZINC ION
Authors:Krojer, T, Savitsky, P, Newman, J.A, Cooper, C.D.O, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Filippakopoulos, P.
Deposit date:2014-01-30
Release date:2014-03-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Cell Rep, 17, 2016
5DXA
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BU of 5dxa by Molmil
Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460)
Descriptor: GLYCEROL, Histone-arginine methyltransferase CARM1, SINEFUNGIN, ...
Authors:Boriack-Sjodin, P.A.
Deposit date:2015-09-23
Release date:2015-11-25
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Acs Chem.Biol., 11, 2016
4IUM
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BU of 4ium by Molmil
Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin
Descriptor: GLYCEROL, Ubiquitin, ZINC ION, ...
Authors:Bailey-Elkin, B.A, James, T.W, Mark, B.L.
Deposit date:2013-01-21
Release date:2013-02-13
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Proc.Natl.Acad.Sci.USA, 110, 2013
6T7Z
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BU of 6t7z by Molmil
KEAP1 IN COMPLEX WITH COMPOUND 44
Descriptor: ACE-CYS-ASA-4FB-GLU-THR-GLY-GLU-CYS-NH2, ACETATE ION, Kelch-like ECH-associated protein 1
Authors:Colarusso, S.
Deposit date:2019-10-23
Release date:2020-09-09
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg.Med.Chem., 28, 2020
5DWQ
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BU of 5dwq by Molmil
Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17)
Descriptor: GLYCEROL, Histone-arginine methyltransferase CARM1, SINEFUNGIN, ...
Authors:Boriack-Sjodin, P.A.
Deposit date:2015-09-22
Release date:2015-11-25
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Acs Chem.Biol., 11, 2016
5DX0
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BU of 5dx0 by Molmil
Crystal structure of CARM1, sinefungin, and H3 peptide (R17)
Descriptor: GLYCEROL, H3 peptide, Histone-arginine methyltransferase CARM1, ...
Authors:Boriack-Sjodin, P.A.
Deposit date:2015-09-23
Release date:2015-11-25
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Acs Chem.Biol., 11, 2016
5DXJ
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BU of 5dxj by Molmil
Crystal structure of CARM1 and sinefungin
Descriptor: GLYCEROL, Histone-arginine methyltransferase CARM1, SINEFUNGIN
Authors:Boriack-Sjodin, P.A.
Deposit date:2015-09-23
Release date:2015-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Acs Chem.Biol., 11, 2016

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