8HKK
| ion channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-27 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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8HIR
| potassium channels | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-21 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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8HKM
| ion channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-27 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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8HK6
| potassium channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-25 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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8HKF
| ion channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | Authors: | Jiang, D.H, Zhang, Z.T. | Deposit date: | 2022-11-25 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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4MH1
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7XRP
| Cryo-EM structure of SARS-CoV-2 spike protein in complex with nanobody C5G2 (localized refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C5G2 nanobody, Spike protein S1 | Authors: | Liu, L, Sun, H, Jiang, Y, Liu, X, Zhao, D, Zheng, Q, Li, S, Xia, N. | Deposit date: | 2022-05-11 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode. J Nanobiotechnology, 20, 2022
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4PZA
| The complex structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c with inorganic phosphate | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase, PHOSPHATE ION | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-03-29 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.776 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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4PZ9
| The native structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-03-28 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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4QIH
| The structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c complexes with VO3 | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase, VANADATE ION | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-05-30 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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6M6Z
| A de novo designed transmembrane nanopore, TMH4C4 | Descriptor: | TMH4C4 | Authors: | Lu, P, Xu, C, Reggiano, G, Xu, Q, DiMaio, F, Baker, D. | Deposit date: | 2020-03-16 | Release date: | 2020-06-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Computational design of transmembrane pores. Nature, 585, 2020
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7VFV
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | Descriptor: | (2~{S})-~{N}-[(2~{S})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFU
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFW
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole, CALCIUM ION, ... | Authors: | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFS
| Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | Deposit date: | 2021-09-13 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7XMF
| Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[4-[3-(4-fluoranyl-2-methyl-phenoxy)azetidin-1-yl]pyrimidin-2-yl]amino]-~{N}-methyl-benzamide, ... | Authors: | Zhang, J.T, Jiang, D.H. | Deposit date: | 2022-04-25 | Release date: | 2022-11-30 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers. Nat.Struct.Mol.Biol., 29, 2022
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7XMG
| Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752 | Descriptor: | (1~{Z})-~{N}-[2-methyl-3-[(~{E})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{H}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-04-25 | Release date: | 2022-11-30 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers. Nat.Struct.Mol.Biol., 29, 2022
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7XM9
| Cryo-EM structure of human NaV1.7/beta1/beta2-XEN907 | Descriptor: | (7~{R})-1'-pentylspiro[6~{H}-furo[3,2-f][1,3]benzodioxole-7,3'-indole]-2'-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | zhang, J.T, Jiang, D.H. | Deposit date: | 2022-04-25 | Release date: | 2022-11-30 | Last modified: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers. Nat.Struct.Mol.Biol., 29, 2022
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5YK1
| The complex structure of Rv3197-AMPPNP from Mycobacterium tuberculosis | Descriptor: | GLYCEROL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable conserved ATP-binding protein ABC transporter, ... | Authors: | Rao, Z.H, Zhang, Q.Q. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018
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5YK0
| The complex structure of Rv3197-ADP from Mycobacterium tuberculosis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Probable conserved ATP-binding protein ABC transporter, ... | Authors: | Rao, Z.H, Zhang, Q.Q. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018
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5YK2
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5VXZ
| High-affinity AXL decoy receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Mathrews, I.I, Kapur, S, Kariolis, M.S, Cochran, J.R. | Deposit date: | 2017-05-24 | Release date: | 2017-06-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J. Clin. Invest., 127, 2017
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5XLL
| Dimer form of M. tuberculosis PknI sensor domain | Descriptor: | Serine/threonine-protein kinase PknI | Authors: | Rao, Z, Yan, Q. | Deposit date: | 2017-05-10 | Release date: | 2018-05-16 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain. Structure, 25, 2017
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5XLM
| Monomer form of M.tuberculosis PknI sensor domain | Descriptor: | Serine/threonine-protein kinase PknI | Authors: | Rao, Z, Yan, Q. | Deposit date: | 2017-05-10 | Release date: | 2018-05-16 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain. Structure, 25, 2017
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5YJZ
| The native crystal structure of Rv3197 from Mycobacterium tuberculosis | Descriptor: | GLYCEROL, Probable conserved ATP-binding protein ABC transporter, SULFATE ION | Authors: | Zhang, Q.Q, Rao, Z.H. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell, 9, 2018
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