7XRP

Cryo-EM structure of SARS-CoV-2 spike protein in complex with nanobody C5G2 (localized refinement)

Summary for 7XRP

• Entry DOI: 10.2210/pdb7xrp/pdb
• EMDB information: 33416
• Descriptor: Spike protein S1, C5G2 nanobody, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2, neutralizing nanobody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 68123.13

Authors

Liu, L.,Sun, H.,Jiang, Y.,Liu, X.,Zhao, D.,Zheng, Q.,Li, S.,Xia, N. (deposition date: 2022-05-11, release date: 2022-10-05)

• Primary citation: Zhao, D.,Liu, L.,Liu, X.,Zhang, J.,Yin, Y.,Luan, L.,Jiang, D.,Yang, X.,Li, L.,Xiong, H.,Xing, D.,Zheng, Q.,Xia, N.,Tao, Y.,Li, S.,Huang, H.; A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode.; J Nanobiotechnology, 20:411-411, 2022; PubMed: 36109732; DOI: 10.1186/s12951-022-01619-y

Experimental method

ELECTRON MICROSCOPY (3.88 Å)