3R9J
 
 | | 4.3A resolution structure of a MinD-MinE(I24N) protein complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division topological specificity factor, Septum site-determining protein minD | | Authors: | Lovell, S, Battaile, K.P, Park, K.-T, Wu, W, Holyoak, T, Lutkenhaus, J. | | Deposit date: | 2011-03-25 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis.
Cell(Cambridge,Mass.), 146, 2011
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3R9I
 | | 2.6A resolution structure of MinD complexed with MinE (12-31) peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division topological specificity factor, Septum site-determining protein minD | | Authors: | Lovell, S, Battaile, K.P, Park, K.-T, Wu, W, Holyoak, T, Lutkenhaus, J. | | Deposit date: | 2011-03-25 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis.
Cell(Cambridge,Mass.), 146, 2011
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7X8R
 | | Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex | | Descriptor: | 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cong, Z.T, Zhou, Q.T, Li, Y, Chen, L.N, Zhang, Z.C, Liang, A.Y, Liu, Q, Wu, X.Y, Dai, A.T, Xia, T, Wu, W, Zhang, Y, Yang, D.H, Wang, M.W. | | Deposit date: | 2022-03-14 | | Release date: | 2022-06-29 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7X8S
 | | Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex | | Descriptor: | 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cong, Z.T, Zhou, Q.T, Li, Y, Chen, L.N, Zhang, Z.C, Liang, A.Y, Liu, Q, Wu, X.Y, Dai, A.T, Xia, T, Wu, W, Zhang, Y, Yang, D.H, Wang, M.W. | | Deposit date: | 2022-03-14 | | Release date: | 2022-06-29 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.
Proc.Natl.Acad.Sci.USA, 119, 2022
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9K2C
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6~{S},9~{a}~{S})-6-(1~{H}-imidazol-5-ylmethyl)-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-~{N}-(phenylmethyl)-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, ... | | Authors: | Li, J.H, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
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9K2K
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY7 | | Descriptor: | (6~{S},9~{a}~{S})-6-(2-methylpropyl)-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-~{N}-(phenylmethyl)-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit | | Authors: | Li, J.H, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
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9K2A
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY27 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6~{S},9~{a}~{S})-6-(3-azidopropyl)-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-~{N}-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, ... | | Authors: | Wei, B.Y, Wang, P.Y, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
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9K2D
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY39 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6~{S},9~{a}~{S})-6-[(2~{S})-butan-2-yl]-8-[(4-methoxynaphthalen-1-yl)methyl]-4,7-bis(oxidanylidene)-~{N}-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit | | Authors: | Wei, B.Y, Wang, P.Y, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
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9K2B
 | | Structure of ClpP from Staphylococcus aureus in complex with ZY18 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6~{S},9~{a}~{S})-6-[(2~{S})-butan-2-yl]-~{N}-[(2~{S})-2-methylbutyl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9~{a}-tetrahydro-2~{H}-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, ... | | Authors: | Wei, B.Y, Wang, P.Y, Wu, W, Zhang, T, Yang, C.-G. | | Deposit date: | 2024-10-17 | | Release date: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
J.Med.Chem., 68, 2025
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7W6V
 | | Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom | | Descriptor: | COBALT (II) ION, Putative copper oxidase | | Authors: | Yang, X, Wu, F, Wu, W, Chen, X, Fan, S, Yu, P, Mao, L. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution.
Sci Adv, 8, 2022
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7FJB
 | | KpAckA (PduW) with AMPPNP, sodium acetate complex structure | | Descriptor: | ACETATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable propionate kinase, ... | | Authors: | Wenyue, W, Zhang, Q, Bartlam, M. | | Deposit date: | 2021-08-03 | | Release date: | 2022-08-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | KpAckA (PduW) with AMPPNP, sodium acetate complex structure
To Be Published
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2M2U
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2M2W
 | | Ternary complex of ASFV Pol X with DNA and MgdGTP | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(P*GP*GP*CP*GP*AP*AP*GP*CP*CP*GP*GP*GP*TP*GP*CP*GP*AP*AP*GP*CP*AP*CP*(DOC))-3', MAGNESIUM ION, ... | | Authors: | Wu, W, Su, M, Tsai, M. | | Deposit date: | 2013-01-03 | | Release date: | 2014-04-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.
J.Am.Chem.Soc., 136, 2014
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2M2V
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2M2T
 | | ASFV Pol X structure | | Descriptor: | Repair DNA polymerase X | | Authors: | Wu, W, Su, M, Tsai, M. | | Deposit date: | 2013-01-03 | | Release date: | 2014-04-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.
J.Am.Chem.Soc., 136, 2014
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9BKV
 | | DosP R97A bent form | | Descriptor: | Oxygen sensor protein DosP, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-04-29 | | Release date: | 2024-11-20 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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9BGV
 | | DosP R97A straight form | | Descriptor: | Oxygen sensor protein DosP, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-04-19 | | Release date: | 2024-11-20 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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9CMF
 | | Substrate bound DosP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, OXYGEN MOLECULE, ... | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-07-15 | | Release date: | 2024-11-20 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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9CLO
 | | DosP R97A with c-di-GMP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, Oxygen sensor protein DosP, ... | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-07-11 | | Release date: | 2024-11-20 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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9CE0
 | | DosP Apo Bent form | | Descriptor: | OXYGEN MOLECULE, Oxygen sensor protein DosP, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-06-25 | | Release date: | 2024-11-20 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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9CDR
 | | DosP Apo straight form | | Descriptor: | OXYGEN MOLECULE, Oxygen sensor protein DosP, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Kumar, P, Kober, D.L. | | Deposit date: | 2024-06-25 | | Release date: | 2024-11-20 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
Nat Commun, 15, 2024
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5V5O
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5V5P
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9M3O
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9M3P
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