2SRC
 
 | | CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP | | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC | | Authors: | Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C. | | Deposit date: | 1998-12-29 | | Release date: | 1999-07-22 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
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6AHV
 | | Crystal structure of human RPP40 | | Descriptor: | Ribonuclease P protein subunit p40 | | Authors: | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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6AHR
 | | Cryo-EM structure of human Ribonuclease P | | Descriptor: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | | Authors: | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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3CRU
 | | Structural characterization of an engineered allosteric protein | | Descriptor: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | | Authors: | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | | Deposit date: | 2008-04-07 | | Release date: | 2009-02-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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3CRT
 | | Structural characterization of an engineered allosteric protein | | Descriptor: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | | Authors: | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | | Deposit date: | 2008-04-07 | | Release date: | 2009-02-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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4M7C
 | | Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | | Descriptor: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | | Authors: | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | | Deposit date: | 2013-08-12 | | Release date: | 2013-09-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Rep, 4, 2013
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6AGB
 | | Cryo-EM structure of yeast Ribonuclease P | | Descriptor: | RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ... | | Authors: | Lan, P, Tan, M, Wu, J, Lei, M. | | Deposit date: | 2018-08-10 | | Release date: | 2018-10-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
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2L3N
 | | Solution structure of Rap1-Taz1 fusion protein | | Descriptor: | DNA-binding protein rap1,Telomere length regulator taz1 | | Authors: | Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H. | | Deposit date: | 2010-09-19 | | Release date: | 2011-01-12 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
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6MLC
 | | PHD6 domain of MLL3 in complex with histone H4 | | Descriptor: | GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ... | | Authors: | Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-09-27 | | Release date: | 2018-10-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
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5DOF
 | | Crystal structure of Tetrahymena p19 | | Descriptor: | Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2015-12-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
Nat.Struct.Mol.Biol., 22, 2015
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5DOI
 | | Crystal structure of Tetrahymena p45N and p19 | | Descriptor: | Telomerase associated protein p45, Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
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5DOK
 | | Crystal structure of Tetrahymena p45C | | Descriptor: | MAGNESIUM ION, Telomerase associated protein p45 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
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5F59
 | | The crystal structure of MLL3 SET domain | | Descriptor: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-04 | | Release date: | 2016-02-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5F6L
 | | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5F5E
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5F6K
 | | Crystal structure of the MLL3-Ash2L-RbBP5 complex | | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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3L82
 | | X-ray Crystal structure of TRF1 and Fbx4 complex | | Descriptor: | F-box only protein 4, Telomeric repeat-binding factor 1 | | Authors: | Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. | | Deposit date: | 2009-12-29 | | Release date: | 2010-03-09 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
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3NBH
 | | Crystal structure of human RMI1C-RMI2 complex | | Descriptor: | RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | | Authors: | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | | Deposit date: | 2010-06-03 | | Release date: | 2010-09-22 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
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6AHU
 | | Cryo-EM structure of human Ribonuclease P with mature tRNA | | Descriptor: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | | Authors: | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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3NBI
 | | Crystal structure of human RMI1 N-terminus | | Descriptor: | RecQ-mediated genome instability protein 1 | | Authors: | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | | Deposit date: | 2010-06-03 | | Release date: | 2010-09-22 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
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3OIP
 | | Crystal structure of Yeast telomere protein Cdc13 OB1 | | Descriptor: | Cell division control protein 13 | | Authors: | Sun, J, Yang, Y, Wan, K, Mao, N, Yu, T.Y, Lin, Y.C, DeZwaan, D.C, Freeman, B.C, Lin, J.J, Lue, N.F, Lei, M. | | Deposit date: | 2010-08-19 | | Release date: | 2010-11-03 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.504 Å) | | Cite: | Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase alpha.
Cell Res., 21, 2011
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3OWT
 | | Crystal structure of S. cerevisiae RAP1-Sir3 complex | | Descriptor: | DNA-binding protein RAP1, Regulatory protein SIR3 | | Authors: | Chen, Y, Yang, Y, Lei, M. | | Deposit date: | 2010-09-20 | | Release date: | 2011-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
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3OIQ
 | | Crystal structure of yeast telomere protein Cdc13 OB1 and the catalytic subunit of DNA polymerase alpha Pol1 | | Descriptor: | Cell division control protein 13, DNA polymerase alpha catalytic subunit A | | Authors: | Sun, J, Yang, Y, Wan, K, Mao, N, Yu, T.Y, Lin, Y.C, DeZwaan, D.C, Freeman, B.C, Lin, J.J, Lue, N.F, Lei, M. | | Deposit date: | 2010-08-19 | | Release date: | 2010-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase alpha.
Cell Res., 21, 2011
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8HMD
 | | base module state 2 of Tetrahymena IFT-A | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | | Authors: | Ma, Y, Wu, J, Lei, M. | | Deposit date: | 2022-12-03 | | Release date: | 2023-06-14 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
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8HMF
 | | head module state 2 of Tetrahymena IFT-A | | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | | Authors: | Ma, Y, Wu, J, Lei, M. | | Deposit date: | 2022-12-03 | | Release date: | 2023-06-14 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
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