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Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
Descriptor:	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Corticoliberin, ...
Authors:	Pioszak, A.A, Xu, H.E.
Deposit date:	2008-09-14
Release date:	2008-09-30
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1. J.Biol.Chem., 283, 2008

Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody
Descriptor:	5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:	Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K.
Deposit date:	2020-07-20
Release date:	2021-07-21
Last modified:	2021-12-15
Method:	ELECTRON MICROSCOPY (3.47 Å)
Cite:	Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021

Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody
Descriptor:	5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:	Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K.
Deposit date:	2020-07-20
Release date:	2021-07-21
Last modified:	2021-12-15
Method:	ELECTRON MICROSCOPY (3.92 Å)
Cite:	Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021

Prefusion RSV F Bound to RV521
Descriptor:	1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl}-6'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one, Fusion glycoprotein F0, SULFATE ION
Authors:	McLellan, J.S.
Deposit date:	2020-11-14
Release date:	2021-04-21
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.94 Å)
Cite:	Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J.Med.Chem., 64, 2021