5Z1I
 
 | | Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kanazawa, H, Hanessian, S, Kondo, J. | | Deposit date: | 2017-12-26 | | Release date: | 2018-05-30 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.903 Å) | | Cite: | Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.
ChemMedChem, 13, 2018
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5Z1H
 | | Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kanazawa, H, Hanessian, S, Kondo, J. | | Deposit date: | 2017-12-26 | | Release date: | 2018-05-30 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.
ChemMedChem, 13, 2018
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4PUF
 | | Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1 | | Descriptor: | E3 ubiquitin-protein ligase SlrP, Thioredoxin | | Authors: | Zouhir, S, Bernal-Bayard, J, Cordero-Alba, M, Cardenal-Munoz, E, Guimaraes, B, Lazar, N, Ramos-Morales, F, Nessler, S. | | Deposit date: | 2014-03-13 | | Release date: | 2014-09-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.296 Å) | | Cite: | The structure of the Slrp-Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family.
Biochem.J., 464, 2014
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4JLV
 | | Crystal structure of the chimerical protein CapA1B1 in complex with ADP-Mg | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, C-terminal fragment of Membrane protein CapA1, Putative uncharacterized protein capB1, ... | | Authors: | Gruszczyk, J, Olivares-Illana, V, Nourikyan, J, Fleurie, A, Bechet, E, Aumont-Nicaise, M, Gueguen-Chaignon, V, Morera, S, Grangeasse, C, Nessler, S. | | Deposit date: | 2013-03-13 | | Release date: | 2014-02-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus
Plos One, 8, 2013
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1JB1
 | | Lactobacillus casei HprK/P Bound to Phosphate | | Descriptor: | HPRK PROTEIN, PHOSPHATE ION | | Authors: | Fieulaine, S, Morera, S, Poncet, S, Monedero, V, Gueguen-Chaignon, V, Galinier, A, Janin, J, Deutscher, J, Nessler, S. | | Deposit date: | 2001-06-01 | | Release date: | 2001-08-08 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | X-ray structure of HPr kinase: a bacterial protein kinase with a P-loop nucleotide-binding domain.
EMBO J., 20, 2001
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1KKL
 | | L.casei HprK/P in complex with B.subtilis HPr | | Descriptor: | CALCIUM ION, HprK protein, PHOSPHOCARRIER PROTEIN HPR | | Authors: | Fieulaine, S, Morera, S, Poncet, S, Galinier, A, Janin, J, Deutscher, J, Nessler, S. | | Deposit date: | 2001-12-10 | | Release date: | 2002-08-28 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr.
Proc.Natl.Acad.Sci.USA, 99, 2002
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4GPK
 | | Crystal structure of NprR in complex with its cognate peptide NprX | | Descriptor: | NprR, NprX peptide | | Authors: | Zouhir, S, Guimaraes, B, Perchat, S, Nicaise, M, Lereclus, D, Nessler, S. | | Deposit date: | 2012-08-21 | | Release date: | 2013-07-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR.
Nucleic Acids Res., 41, 2013
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1KKM
 | | L.casei HprK/P in complex with B.subtilis P-Ser-HPr | | Descriptor: | CALCIUM ION, HprK protein, PHOSPHATE ION, ... | | Authors: | Fieulaine, S, Morera, S, Poncet, S, Galinier, A, Janin, J, Deutscher, J, Nessler, S. | | Deposit date: | 2001-12-10 | | Release date: | 2002-08-28 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr.
Proc.Natl.Acad.Sci.USA, 99, 2002
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3WRU
 | | Crystal structure of the bacterial ribosomal decoding site in complex with synthetic aminoglycoside with F-HABA group | | Descriptor: | (2R,3R)-4-amino-N-[(1R,2S,3R,4R,5S)-5-amino-4-[(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)oxy]-3-{[3-O-(2,6-diamino-2,3,4,6-tetradeoxy-beta-L-threo-hexopyranosyl)-beta-D-ribofuranosyl]oxy}-2-hydroxycyclohexyl]-3-fluoro-2-hydroxybutanamide, POTASSIUM ION, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Maianti, J.P, Kanazawa, H, Dozzo, P, Feeney, L.A, Armstrong, E.S, Kondo, J, Hanessian, S. | | Deposit date: | 2014-02-27 | | Release date: | 2014-11-05 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs
Acs Chem.Biol., 9, 2014
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1KO7
 | | X-ray structure of the HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution | | Descriptor: | Hpr kinase/phosphatase, PHOSPHATE ION | | Authors: | Marquez, J.A, Hasenbein, S, Koch, B, Fieulaine, S, Nessler, S, Hengstenberg, W, Scheffzek, K. | | Deposit date: | 2001-12-20 | | Release date: | 2002-04-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions.
Proc.Natl.Acad.Sci.USA, 99, 2002
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5JUB
 | | Crystal structure of ComR from S.thermophilus in complex with DNA and its signalling peptide ComS. | | Descriptor: | ComS, Transcriptional regulator, pComX-for, ... | | Authors: | Talagas, A, Fontaine, L, Ledesma-Garcia, L, Li de la Sierra-Gallay, I, Hols, P, Nessler, S. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-26 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.
PLoS Pathog., 12, 2016
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4JMP
 | | Crystal structure of the chimerical protein CapA2B2 | | Descriptor: | C-terminal fragment of CapA, Protein tyrosine kinase | | Authors: | Olivares-Illana, V, Morera, S, Grangeasse, C, Nessler, S. | | Deposit date: | 2013-03-14 | | Release date: | 2014-02-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus
Plos One, 8, 2013
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3LA6
 | | Octameric kinase domain of the E. coli tyrosine kinase Wzc with bound ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Tyrosine-protein kinase wzc | | Authors: | Gruszczyk, J, Nessler, S, Gueguen-Chaignon, V, Vigouroux, A, Bechet, E, Grangeasse, C. | | Deposit date: | 2010-01-06 | | Release date: | 2010-08-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export
Mol.Microbiol., 77, 2010
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6JBF
 | | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F) | | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kanazawa, H, Auffinger, P, Hanessian, S, Kondo, J. | | Deposit date: | 2019-01-25 | | Release date: | 2020-01-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F)
To Be Published
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6JBG
 | | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F) | | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-glucopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kanazawa, H, Auffinger, P, Hanessian, S, Kondo, J. | | Deposit date: | 2019-01-25 | | Release date: | 2020-01-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F)
To Be Published
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2AK7
 | | structure of a dimeric P-Ser-Crh | | Descriptor: | HPr-like protein crh, SULFATE ION | | Authors: | Chaptal, V, Gueguen-Chaignon, V, Poncet, S, Lecampion, C, Lariviere, L, Meyer, P, Galinier, A, Deutscher, J, Nessler, S, Morera, S. | | Deposit date: | 2005-08-03 | | Release date: | 2006-06-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structure of a domain-swapped dimer of Ser46-phosphorylated Crh from Bacillus subtilis.
Proteins, 63, 2006
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2PWT
 | | Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group | | Descriptor: | 22-mer of the ribosomal decoding site, DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162 | | Authors: | Kondo, J, Pachamuthu, K, Francois, B, Szychowski, J, Hanessian, S, Westhof, E. | | Deposit date: | 2007-05-13 | | Release date: | 2007-09-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity
Chemmedchem, 2, 2007
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2FEP
 | | Structure of truncated CcpA in complex with P-Ser-HPr and Sulfate ions | | Descriptor: | Catabolite control protein A, Phosphocarrier protein HPr, SULFATE ION | | Authors: | Chaptal, V, Gueguen-Chaignon, V, Poncet, S, Lecampion, C, Meyer, P, Deutscher, J, Galinier, A, Nessler, S. | | Deposit date: | 2005-12-16 | | Release date: | 2006-06-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural analysis of B. subtilis CcpA effector binding site.
Proteins, 64, 2006
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3S4P
 | | Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue | | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Szychowski, J, Kondo, J, Zahr, O, Auclair, K, Westhof, E, Hanessian, S, Keillor, J.W. | | Deposit date: | 2011-05-20 | | Release date: | 2011-09-21 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues
Chemmedchem, 6, 2011
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3U3W
 | | Crystal Structure of Bacillus thuringiensis PlcR in complex with the peptide PapR7 and DNA | | Descriptor: | 5'-D(P*AP*TP*AP*TP*GP*AP*AP*AP*TP*AP*TP*TP*GP*CP*AP*TP*AP*G)-3', 5'-D(P*CP*TP*AP*TP*GP*CP*AP*AP*TP*AP*TP*TP*TP*CP*AP*TP*AP*T)-3', C-terminus heptapeptide from PapR protein, ... | | Authors: | Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S. | | Deposit date: | 2011-10-06 | | Release date: | 2013-01-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4FSC
 | | Crystal Structure of Bacillus thuringiensis PlcR in its apo form | | Descriptor: | Transcriptional activator PlcR protein | | Authors: | Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S. | | Deposit date: | 2012-06-27 | | Release date: | 2013-03-13 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GPX
 | | Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P212121 form) | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kondo, J, Koganei, M, Maianti, J.P, Ly, V.L, Hanessian, S. | | Deposit date: | 2012-08-22 | | Release date: | 2013-04-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites
Chemmedchem, 8, 2013
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4GPW
 | | Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form) | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kondo, J, Koganei, M, Maianti, J.P, Ly, V.L, Hanessian, S. | | Deposit date: | 2012-08-22 | | Release date: | 2013-04-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites
Chemmedchem, 8, 2013
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4GPY
 | | Crystal structure of the bacterial ribosomal decoding site in complex with 6'-hydroxysisomicin | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') | | Authors: | Kondo, J, Koganei, M, Maianti, J.P, Ly, V.L, Hanessian, S. | | Deposit date: | 2012-08-22 | | Release date: | 2013-04-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites
Chemmedchem, 8, 2013
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2GDE
 | | Thrombin in complex with inhibitor | | Descriptor: | (R)-3-((2S,3R)-1-((2S,3AR,5S,6S,7AS)-2-(2-(1-CARBAMIMIDOYL-2,5-DIHYDRO-1H-PYRROL-3-YL)ETHYLCARBAMOYL)-5,6-DIHYDROXYOCTAHYDRO-1H-INDOL-1-YL)-3-CHLORO-4-METHYL-1-OXOPENTAN-2-YLAMINO)-2-METHOXY-3-OXOPROPYL HYDROGEN SULFATE, Hirudin, SODIUM ION, ... | | Authors: | Xue, Y. | | Deposit date: | 2006-03-16 | | Release date: | 2007-03-20 | | Last modified: | 2013-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Total synthesis and structural confirmation of chlorodysinosin A.
J.Am.Chem.Soc., 128, 2006
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