4GPY
Crystal structure of the bacterial ribosomal decoding site in complex with 6'-hydroxysisomicin
Summary for 4GPY
Entry DOI | 10.2210/pdb4gpy/pdb |
Related | 4F8U 4F8V 4GPW 4GPX |
Descriptor | RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total) |
Functional Keywords | ribosome, aminoglycoside, rna-antibiotic complex, antiprotozoal activity, antibacterial activity, rna/antibiotic |
Total number of polymer chains | 2 |
Total formula weight | 15637.87 |
Authors | Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S. (deposition date: 2012-08-22, release date: 2013-04-03, Last modification date: 2024-03-20) |
Primary citation | Kondo, J.,Koganei, M.,Maianti, J.P.,Ly, V.L.,Hanessian, S. Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites Chemmedchem, 8:733-739, 2013 Cited by PubMed: 23436717DOI: 10.1002/cmdc.201200579 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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