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3Q7G
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BU of 3q7g by Molmil
Crystal Structure of E2 domain of Human Amyloid Precursor-Like Protein 1 in complex with SOS (sucrose octasulfate)
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Amyloid-like protein 1
Authors:Xue, Y, Ha, Y.
Deposit date:2011-01-04
Release date:2011-06-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate.
J.Biol.Chem., 286, 2011
3Q7L
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BU of 3q7l by Molmil
Crystal structure of the E2 domain of amyloid precursor-like protein 1
Descriptor: Amyloid-like protein 1, SULFATE ION
Authors:Xue, Y, Ha, Y.
Deposit date:2011-01-05
Release date:2011-06-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate.
J.Biol.Chem., 286, 2011
7N81
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BU of 7n81 by Molmil
Crystal Structure of PI5P4KIIBeta complex with CC260
Descriptor: (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-11
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7J
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BU of 7n7j by Molmil
Crystal Structure of PI5P4KIIAlpha complex with AMPPNP
Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ...
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N80
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BU of 7n80 by Molmil
Crystal Structure of PI5P4KIIBeta
Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-11
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7M
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BU of 7n7m by Molmil
Crystal Structure of PI5P4KIIAlpha complex with BI-2536
Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7K
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BU of 7n7k by Molmil
Crystal Structure of PI5P4KIIAlpha complex with AMPPNP
Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ...
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7L
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BU of 7n7l by Molmil
Crystal Structure of PI5P4KIIAlpha complex with BI-D1870
Descriptor: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N71
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BU of 7n71 by Molmil
Crystal Structure of PI5P4KIIAlpha
Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-09
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6Z
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BU of 7n6z by Molmil
Crystal Structure of PI5P4KIIAlpha
Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-09
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7N
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BU of 7n7n by Molmil
Crystal Structure of PI5P4KIIAlpha complex with Volasertib
Descriptor: N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N7O
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BU of 7n7o by Molmil
Crystal Structure of PI5P4KIIAlpha complex with Palbociclib
Descriptor: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION
Authors:Chen, S, Ha, Y.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Proc.Natl.Acad.Sci.USA, 118, 2021
3K6B
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BU of 3k6b by Molmil
X-ray crystal structure of the E2 domain of APL-1 from C. elegans, in complex with sucrose octasulfate (SOS)
Descriptor: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Beta-amyloid-like protein
Authors:Hoopes, J.T, Ha, Y.
Deposit date:2009-10-08
Release date:2009-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site
J.Biol.Chem., 285, 2010
3QMK
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BU of 3qmk by Molmil
Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Amyloid-like protein 1, SULFATE ION
Authors:Xue, Y, Ha, Y.
Deposit date:2011-02-04
Release date:2011-10-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
3K66
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BU of 3k66 by Molmil
X-ray crystal structure of the E2 domain of C. elegans APL-1
Descriptor: Beta-amyloid-like protein
Authors:Hoopes, J.T, Ha, Y.
Deposit date:2009-10-08
Release date:2009-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site
J.Biol.Chem., 285, 2010
4H1D
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BU of 4h1d by Molmil
Cocrystal structure of GlpG and DFP
Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease GlpG
Authors:Xue, Y, Ha, Y.
Deposit date:2012-09-10
Release date:2013-05-01
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.8975 Å)
Cite:Large lateral movement of transmembrane helix s5 is not required for substrate access to the active site of rhomboid intramembrane protease.
J.Biol.Chem., 288, 2013
3B45
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BU of 3b45 by Molmil
Crystal structure of GlpG at 1.9A resolution
Descriptor: glpG, nonyl beta-D-glucopyranoside
Authors:Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y.
Deposit date:2007-10-23
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
1TI8
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BU of 1ti8 by Molmil
H7 Haemagglutinin
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ...
Authors:Russell, R.J, Gamblin, S.J, Haire, L.F, Stevens, D.J, Xaio, B, Ha, Y, Skehel, J.J.
Deposit date:2004-06-02
Release date:2005-06-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes.
Virology, 325, 2004
3B44
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BU of 3b44 by Molmil
Crystal structure of GlpG W136A mutant
Descriptor: glpG, nonyl beta-D-glucopyranoside
Authors:Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y.
Deposit date:2007-10-23
Release date:2008-01-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
1OTH
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BU of 1oth by Molmil
CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMOYLASE COMPLEXED WITH N-PHOSPHONACETYL-L-ORNITHINE
Descriptor: N-(PHOSPHONOACETYL)-L-ORNITHINE, PROTEIN (ORNITHINE TRANSCARBAMOYLASE)
Authors:Shi, D, Morizono, H, Ha, Y, Aoyagi, M, Tuchman, N, Allewell, N.M.
Deposit date:1998-10-06
Release date:1999-10-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:1.85-A resolution crystal structure of human ornithine transcarbamoylase complexed with N-phosphonacetyl-L-ornithine. Catalytic mechanism and correlation with inherited deficiency.
J.Biol.Chem., 273, 1998
6W2L
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BU of 6w2l by Molmil
Crystal structure of human dehydrodolichyl diphosphate synthase (NgBR/DHDDS) in complex with Mg and IPP
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, ...
Authors:Edani, B.H, Ha, Y, Sessa, W.C.
Deposit date:2020-03-06
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Structural elucidation of thecis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.
Proc.Natl.Acad.Sci.USA, 117, 2020
3UBB
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BU of 3ubb by Molmil
The crystal structure of GlpG in complex with a phosphonofluoridate inhibitor
Descriptor: Rhomboid protease glpG, propan-2-yl hydrogen (S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl]phosphonate
Authors:Xue, Y, Ha, Y.
Deposit date:2011-10-24
Release date:2012-06-13
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S' Subsites.
Biochemistry, 51, 2012
3TXT
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BU of 3txt by Molmil
Crystal structure of GlpG in complex with inhibitor DFP
Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG
Authors:Xue, Y, Ha, Y.
Deposit date:2011-09-23
Release date:2011-12-07
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor
To be Published
3S0X
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BU of 3s0x by Molmil
The crystal structure of GxGD membrane protease FlaK
Descriptor: Peptidase A24B, FlaK domain protein
Authors:Hu, J, Xue, Y, Ha, Y.
Deposit date:2011-05-13
Release date:2011-08-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The crystal structure of GXGD membrane protease FlaK.
Nature, 475, 2011
1BG7
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BU of 1bg7 by Molmil
LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?
Descriptor: CALCIUM ION, FERRITIN
Authors:Takagi, H, Shi, D, Ha, Y, Allewell, N.M, Theil, E.C.
Deposit date:1998-06-05
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?
J.Biol.Chem., 273, 1998

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