4HD4
| Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2012-10-02 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Influencing the monophenolase/diphenolase activity ratio in tyrosinase. Biochim.Biophys.Acta, 1834, 2013
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4Z2R
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4Z2T
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4Z2U
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4X6U
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Kanteev, M, Dror, A, Gihaz, S, Fishman, A. | Deposit date: | 2014-12-09 | Release date: | 2015-06-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Structural insights into methanol-stable variants of lipase T6 from Geobacillus stearothermophilus. Appl.Microbiol.Biotechnol., 99, 2015
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4X7B
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant H86Y/A269T | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Kanteev, M, Dror, A, Gihaz, S, Fishman, A. | Deposit date: | 2014-12-09 | Release date: | 2015-06-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into methanol-stable variants of lipase T6 from Geobacillus stearothermophilus. Appl.Microbiol.Biotechnol., 99, 2015
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4X85
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant H86Y/A269T/R374W | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Kanteev, M, Dror, A, Gihaz, S, Fishman, A. | Deposit date: | 2014-12-10 | Release date: | 2015-06-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.192 Å) | Cite: | Structural insights into methanol-stable variants of lipase T6 from Geobacillus stearothermophilus. Appl.Microbiol.Biotechnol., 99, 2015
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4HD7
| Crystal Structure of Tyrosinase from Bacillus megaterium V218G mutant soaked in CuSO4 | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2012-10-02 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Influencing the monophenolase/diphenolase activity ratio in tyrosinase. Biochim.Biophys.Acta, 1834, 2013
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4J6V
| Crystal Structure of Tyrosinase from Bacillus megaterium N205D mutant | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Kanteev, M, Goldfeder, M, Adir, N, Fishman, A. | Deposit date: | 2013-02-12 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The mechanism of copper uptake by tyrosinase from Bacillus megaterium. J.Biol.Inorg.Chem., 18, 2013
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4J6T
| Crystal Structure of Tyrosinase from Bacillus megaterium F197A mutant | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Kanteev, M, Goldfeder, M, Adir, N, Fishman, A. | Deposit date: | 2013-02-12 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | The mechanism of copper uptake by tyrosinase from Bacillus megaterium. J.Biol.Inorg.Chem., 18, 2013
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4J6U
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5OAE
| Crystal Structure of tyrosinase from Bacillus megaterium with SVF inhibitor in the active site | Descriptor: | 1-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanone, COPPER (II) ION, Tyrosinase | Authors: | Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. | Deposit date: | 2017-06-21 | Release date: | 2018-04-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
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6QXD
| Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site. | Descriptor: | (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, COPPER (II) ION, Tyrosinase | Authors: | Deri Zenaty, B, Gitto, R, Pazy, Y, Fishman, A. | Deposit date: | 2019-03-07 | Release date: | 2019-06-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.317 Å) | Cite: | Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur.J.Med.Chem., 178, 2019
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6S3V
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant E251C/G332C | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Bash, Y, Rush, I, Shahar, A, Pazy, Y, Fishman, A. | Deposit date: | 2019-06-26 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Bridges to Stability: Engineering Disulfide Bonds Towards Enhanced Lipase Biodiesel Synthesis Chemcatchem, 2019
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6EI4
| Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site | Descriptor: | COPPER (II) ION, Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone | Authors: | Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. | Deposit date: | 2017-09-17 | Release date: | 2018-04-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
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6EM0
| Crystal Structure of 2-hydroxybiphenyl 3-monooxygenase M321A from Pseudomonas azelaica | Descriptor: | 2-hydroxybiphenyl-3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Deri, B, Bregman-Cohen, A, Pazy Benhar, Y, Fishman, A. | Deposit date: | 2017-10-01 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Altering 2-Hydroxybiphenyl 3-Monooxygenase Regioselectivity by Protein Engineering for the Production of a New Antioxidant. Chembiochem, 19, 2018
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6S3J
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 variant E134C/F149C | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Bash, Y, Rush, I, Shahar, A, Pazy, Y, Fishman, A. | Deposit date: | 2019-06-25 | Release date: | 2019-10-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bridges to Stability: Engineering Disulfide Bonds Towards Enhanced Lipase Biodiesel Synthesis Chemcatchem, 2019
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6S3G
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 variant A187C/F291C | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Bash, Y, Rush, I, Shahar, A, Pazy, Y, Fishman, A. | Deposit date: | 2019-06-25 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bridges to Stability: Engineering Disulfide Bonds Towards Enhanced Lipase Biodiesel Synthesis Chemcatchem, 2019
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4P6T
| Crystal Structure of tyrosinase from Bacillus megaterium with p-tyrosol in the active site | Descriptor: | 4-(2-hydroxyethyl)phenol, COPPER (II) ION, Tyrosinase | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4P6S
| Crystal Structure of tyrosinase from Bacillus megaterium with L-DOPA in the active site | Descriptor: | 3,4-DIHYDROXYPHENYLALANINE, Tyrosinase, ZINC ION | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4P6R
| Crystal Structure of tyrosinase from Bacillus megaterium with tyrosine in the active site | Descriptor: | TYROSINE, Tyrosinase, ZINC ION | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4D87
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6FZC
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 variant L184F/L360F | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Kanteev, M, Pazy, Y, Fishman, A. | Deposit date: | 2018-03-14 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Filling the Void: Introducing Aromatic Interactions into Solvent Tunnels To Enhance Lipase Stability in Methanol. Appl.Environ.Microbiol., 84, 2018
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6FZ9
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant A187F/L360F | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Kanteev, M, Pazy, Y, Fishman, A. | Deposit date: | 2018-03-14 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.2463 Å) | Cite: | Filling the Void: Introducing Aromatic Interactions into Solvent Tunnels To Enhance Lipase Stability in Methanol. Appl.Environ.Microbiol., 84, 2018
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6FZA
| Crystal Structure of lipase from Geobacillus stearothermophilus T6 methanol stable variant A187F | Descriptor: | CALCIUM ION, Lipase, ZINC ION | Authors: | Gihaz, S, Kanteev, M, Pazy, Y, Fishman, A. | Deposit date: | 2018-03-14 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Filling the Void: Introducing Aromatic Interactions into Solvent Tunnels To Enhance Lipase Stability in Methanol. Appl.Environ.Microbiol., 84, 2018
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