1YIO
 
 | | Crystallographic structure of response regulator StyR from Pseudomonas fluorescens | | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, response regulatory protein | | Authors: | Milani, M, Leoni, L, Rampioni, G, Zennaro, E, Ascenzi, P, Bolognesi, M. | | Deposit date: | 2005-01-12 | | Release date: | 2005-09-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism
STRUCTURE, 13, 2005
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1KR7
 | | Crystal structure of the nerve tissue mini-hemoglobin from the nemertean worm Cerebratulus lacteus | | Descriptor: | ACETATE ION, Neural globin, OXYGEN MOLECULE, ... | | Authors: | Pesce, A, Nardini, M, Dewilde, S, Geuens, E, Yamauchi, k, Ascenzi, P, Riggs, A.F, Moens, L, Bolognesi, M. | | Deposit date: | 2002-01-09 | | Release date: | 2002-05-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The 109 residue nerve tissue minihemoglobin from Cerebratulus lacteus highlights striking structural plasticity of the alpha-helical globin fold
Structure, 10, 2002
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1MOH
 | | FERRIC MONOMERIC HEMOGLOBIN I (HB I) | | Descriptor: | HYDROSULFURIC ACID, MONOMERIC HEMOGLOBIN I, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Rizzi, M, Wittenberg, J.B, Ascenzi, P, Bolognesi, M. | | Deposit date: | 1996-02-27 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural bases for sulfide recognition in Lucina pectinata hemoglobin I.
J.Mol.Biol., 258, 1996
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1OJ6
 | | Human brain neuroglobin three-dimensional structure | | Descriptor: | Neuroglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Pesce, A, Dewilde, S, Nardini, M, Moens, L, Ascenzi, P, Hankeln, T, Burmester, T, Bolognesi, M. | | Deposit date: | 2003-07-03 | | Release date: | 2003-09-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Human Brain Neuroglobin Structure Reveals a Distinct Mode of Controlling Oxygen Affinity
Structure, 11, 2003
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1NGK
 | | Crystallographic Structure of Mycobacterium tuberculosis Hemoglobin O | | Descriptor: | CYANIDE ION, Hemoglobin-like protein HbO, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Milani, M, Savard, P.-Y, Oullet, H, Ascenzi, P, Guertin, M, Bolognesi, M. | | Deposit date: | 2002-12-17 | | Release date: | 2003-05-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | A TyrCD1/TrpG8 hydrogen bond network and a TyrB10-TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O
Proc.Natl.Acad.Sci.USA, 100, 2003
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1NXN
 | | SOLUTION STRUCTURE OF CONTRYPHAN-VN | | Descriptor: | CONTRYPHAN-VN, MAJOR FORM (CIS CONFORMER) | | Authors: | Eliseo, T, Cicero, D.O, Polticelli, F, Schinina, M.E, Massilia, G.R, Paci, M, Ascenzi, P. | | Deposit date: | 2003-02-11 | | Release date: | 2003-03-04 | | Last modified: | 2020-06-24 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator
Biopolymers, 74, 2004
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1H97
 | | Trematode hemoglobin from Paramphistomum epiclitum | | Descriptor: | Globin-3, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Pesce, A, Dewilde, S, Kiger, L, Milani, M, Ascenzi, P, Marden, M.C, Van Hauwaert, M.L, Vanfleteren, J, Moens, L, Bolognesi, M. | | Deposit date: | 2001-03-02 | | Release date: | 2001-06-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Very High Resolution Structure of a Trematode Hemoglobin Displaying a Tyrb10-Tyre7 Heme Distal Residue Pair and High Oxygen Affinity
J.Mol.Biol., 309, 2001
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1SWM
 | | X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION | | Descriptor: | AZIDE ION, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Rizzi, M, Ascenzi, P, Coda, A, Brunori, M, Bolognesi, M. | | Deposit date: | 1992-03-03 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution.
J.Mol.Biol., 217, 1991
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1AFE
 | | HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP | | Descriptor: | 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER, 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ... | | Authors: | De Simone, G, Balliano, G, Milla, P, Gallina, C, Giordano, C, Tarricone, C, Rizzi, M, Bolognesi, M, Ascenzi, P. | | Deposit date: | 1997-03-06 | | Release date: | 1997-12-03 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
J.Mol.Biol., 269, 1997
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1KFR
 | | Structural plasticity in the eight-helix fold of a trematode hemoglobin | | Descriptor: | Hemoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Milani, M, Pesce, A, Dewilde, S, Ascenzi, P, Moens, L, Bolognesi, M. | | Deposit date: | 2001-11-22 | | Release date: | 2002-04-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural plasticity in the eight-helix fold of a trematode haemoglobin.
Acta Crystallogr.,Sect.D, 58, 2002
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1AE8
 | | HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP | | Descriptor: | 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ... | | Authors: | De Simone, G, Balliano, G, Milla, P, Gallina, C, Giordano, C, Tarricone, C, Rizzi, M, Bolognesi, M, Ascenzi, P. | | Deposit date: | 1997-03-06 | | Release date: | 1997-12-03 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
J.Mol.Biol., 269, 1997
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1UMA
 | | ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUDIN I, ... | | Authors: | Nardini, M, Pesce, A, Rizzi, M, Casale, E, Ferraccioli, R, Balliano, G, Milla, P, Ascenzi, P, Bolognesi, M. | | Deposit date: | 1996-03-26 | | Release date: | 1996-11-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
J.Mol.Biol., 258, 1996
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1H82
 | | STRUCTURE OF POLYAMINE OXIDASE IN COMPLEX WITH GUAZATINE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, N-{8-[(8-{[(E)-AMINO(IMINO)METHYL]AMINO}OCTYL)AMINO]OCTYL}GUANIDINE, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 2001-01-24 | | Release date: | 2001-01-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
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1H84
 | | COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ethylN11((cycloheptyl)methyl)4,8diazaundecane at pH 4.6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(3-{[3-(METHYLAMINO)PROPYL]AMINO}PROPYL)AMINO]PROPANE-1,1-DIOL, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 2001-01-24 | | Release date: | 2001-01-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
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1H83
 | | STRUCTURE OF POLYAMINE OXIDASE IN COMPLEX WITH 1,8-DIAMINOOCTANE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, OCTANE 1,8-DIAMINE, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 2001-01-24 | | Release date: | 2001-01-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
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1H81
 | | STRUCTURE OF POLYAMINE OXIDASE IN THE REDUCED STATE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, POLYAMINE OXIDASE, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 2001-01-24 | | Release date: | 2001-01-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
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1H86
 | | COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ethylN11((cycloheptyl)methyl)4,8diazaundecane at pH 7.0 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(3-{[3-(METHYLAMINO)PROPYL]AMINO}PROPYL)AMINO]PROPANE-1,1-DIOL, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 2001-01-24 | | Release date: | 2001-01-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
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1IDR
 | | CRYSTAL STRUCTURE OF THE TRUNCATED-HEMOGLOBIN-N FROM MYCOBACTERIUM TUBERCULOSIS | | Descriptor: | HEMOGLOBIN HBN, OXYGEN MOLECULE, PHOSPHATE ION, ... | | Authors: | Milani, M, Pesce, A, Ascenzi, P, Guertin, M, Bolognesi, M. | | Deposit date: | 2001-04-05 | | Release date: | 2001-08-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme.
EMBO J., 20, 2001
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2C0K
 | | The structure of hemoglobin from the botfly Gasterophilus intestinalis | | Descriptor: | HEMOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Pesce, A, Nardini, M, Dewilde, S, Hoogewijs, D, Ascenzi, P, Moens, L, Bolognesi, M. | | Deposit date: | 2005-09-05 | | Release date: | 2005-11-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Modulation of Oxygen Binding to Insect Hemoglobins: The Structure of Hemoglobin from the Botfly Gasterophilus Intestinalis.
Protein Sci., 14, 2005
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2BK9
 | | Drosophila Melanogaster globin | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, CG9734-PA, CHLORIDE ION, ... | | Authors: | de Sanctis, D, Dewilde, S, Pesce, A, Moens, L, Ascenzi, P, Hankeln, T, Burmester, T, Ponassi, M, Nardini, M, Bolognesi, M. | | Deposit date: | 2005-02-14 | | Release date: | 2005-05-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Bishistidyl Heme Hexacoordination, a Key Structural Property in Drosophila Melanogaster Hemoglobin
J.Biol.Chem., 280, 2005
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2G3H
 | | Cyanide Binding and Heme Cavity Conformational Transitions in Drosophila melanogaster Hexa-coordinate Hemoglobin | | Descriptor: | CHLORIDE ION, CYANIDE ION, MAGNESIUM ION, ... | | Authors: | de Sanctis, D, Ascenzi, P, Bocedi, A, Dewilde, S, Burmester, T, Hankeln, T, Moens, L, Bolognesi, M. | | Deposit date: | 2006-02-20 | | Release date: | 2006-10-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Cyanide binding and heme cavity conformational transitions in Drosophila melanogaster hexacoordinate hemoglobin.
Biochemistry, 45, 2006
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1B0B
 | | HEMOGLOBIN I FROM THE CLAM LUCINA PECTINATA, CYANIDE COMPLEX AT 100 KELVIN | | Descriptor: | CYANIDE ION, HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Rosano, C, Rizzi, M, Ascenzi, P, Bolognesi, M. | | Deposit date: | 1998-11-06 | | Release date: | 2000-02-18 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study.
Biophys.J., 77, 1999
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1B5Q
 | | A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE, ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 1999-01-07 | | Release date: | 2000-01-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7, 1999
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1B37
 | | A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, PROTEIN (POLYAMINE OXIDASE), ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 1998-12-17 | | Release date: | 1999-12-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7, 1999
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2VHB
 | | AZIDE ADDUCT OF THE BACTERIAL HEMOGLOBIN FROM VITREOSCILLA STERCORARIA | | Descriptor: | AZIDE ION, HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Tarricone, C, Galizzi, A, Coda, A, Ascenzi, P, Bolognesi, M. | | Deposit date: | 1997-02-19 | | Release date: | 1998-02-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Unusual structure of the oxygen-binding site in the dimeric bacterial hemoglobin from Vitreoscilla sp.
Structure, 5, 1997
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