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1AE8

HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP

Summary for 1AE8
Entry DOI10.2210/pdb1ae8/pdb
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), blood coagulation, n-ethoxycarbonyl-d-phe-pro-alfa-azalys-p-nitrophenylester, serine proteinase inhibition, glycosylated protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains3
Total formula weight35880.88
Authors
De Simone, G.,Balliano, G.,Milla, P.,Gallina, C.,Giordano, C.,Tarricone, C.,Rizzi, M.,Bolognesi, M.,Ascenzi, P. (deposition date: 1997-03-06, release date: 1997-12-03, Last modification date: 2023-08-02)
Primary citationDe Simone, G.,Balliano, G.,Milla, P.,Gallina, C.,Giordano, C.,Tarricone, C.,Rizzi, M.,Bolognesi, M.,Ascenzi, P.
Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
J.Mol.Biol., 269:558-569, 1997
Cited by
PubMed: 9217260
DOI: 10.1006/jmbi.1997.1037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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