8OER
 
 | | MUC5B amino acids 26-1435 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-5B | | Authors: | Khmelnitsky, L, Fass, D. | | Deposit date: | 2023-03-12 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Pulmonary Fibrosis Linked to Impaired Mucin 5B Supramolecular Assembly
To Be Published
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8OV0
 | | MUC5AC CysD7 amino acids 3518-3626 | | Descriptor: | CALCIUM ION, CHLORIDE ION, Mucin-5AC | | Authors: | Khmelnitsky, L, Milo, A, Dym, O, Fass, D. | | Deposit date: | 2023-04-25 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Diversity of CysD domains in gel-forming mucins.
Febs J., 290, 2023
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6GC2
 | | AbLIFT: Antibody stability and affinity optimization by computational design of the variable light-heavy chain interface | | Descriptor: | Heavy chain, Light Chain | | Authors: | Warszawski, S, Katz, A, Khmelnitsky, L, Ben Nissan, G, Javitt, G, Dym, O, Unger, T, Knop, O, Diskin, R, Albeck, S, Fass, D, Sharon, M, Fleishman, S.J. | | Deposit date: | 2018-04-17 | | Release date: | 2019-05-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Plos Comput.Biol., 15, 2019
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7POV
 | | MUC2 Tubules of D1D2D3 domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-09-10 | | Release date: | 2022-02-16 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7PP6
 | | MUC2 Tubules of D1D2D3 domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-09-13 | | Release date: | 2022-02-16 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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3ED3
 | | Crystal Structure of the Yeast Dithiol/Disulfide Oxidoreductase Mpd1p | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Protein disulfide-isomerase MPD1 | | Authors: | Vitu, E, Greenblatt, H.M, Fass, D. | | Deposit date: | 2008-09-02 | | Release date: | 2008-11-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Yeast Mpd1p reveals the structural diversity of the protein disulfide isomerase family
J.Mol.Biol., 384, 2008
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1RP4
 | | Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell | | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, CADMIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Gross, E, Kastner, D.B, Kaiser, C.A, Fass, D. | | Deposit date: | 2003-12-03 | | Release date: | 2004-06-08 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of ero1p, source of disulfide bonds for oxidative protein folding in the cell.
Cell(Cambridge,Mass.), 117, 2004
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4P2L
 | | Quiescin Sulfhydryl Oxidase from Rattus norvegicus | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Sulfhydryl oxidase 1 | | Authors: | Gat, Y, Fass, D. | | Deposit date: | 2014-03-04 | | Release date: | 2014-06-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Enzyme structure captures four cysteines aligned for disulfide relay.
Protein Sci., 23, 2014
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4YEQ
 | | L4b Domain of Human Laminin alpha-2 | | Descriptor: | Laminin subunit alpha-2 | | Authors: | Toot, M, Gat, Y, Fass, D. | | Deposit date: | 2015-02-24 | | Release date: | 2015-05-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.
Febs J., 282, 2015
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4YEP
 | | L4b Domain of Human Laminin alpha-2 | | Descriptor: | 1,2-ETHANEDIOL, Laminin subunit alpha-2 | | Authors: | Toot, M, Gat, Y, Fass, D. | | Deposit date: | 2015-02-24 | | Release date: | 2015-05-27 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.
Febs J., 282, 2015
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3GWL
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3GWN
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1RQ1
 | | Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell | | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, CADMIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Gross, E, Kastner, D.B, Kaiser, C.A, Fass, D. | | Deposit date: | 2003-12-04 | | Release date: | 2004-06-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of ero1p, source of disulfide bonds for oxidative protein folding in the cell.
Cell(Cambridge,Mass.), 117, 2004
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7PMV
 | | VWF Tubules of D1D2D'D3 domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-09-02 | | Release date: | 2022-02-23 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7PNF
 | | VWF Tubules of D1D2D'D3 domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-09-06 | | Release date: | 2022-02-23 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (4.35 Å) | | Cite: | Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5D8I
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5D93
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6TM2
 | | Human MUC2 AAs 21-1397 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Javitt, G, Khmelnitsky, L, Albert, L, Elad, N, Ilani, T, Diskin, R, Fass, D. | | Deposit date: | 2019-12-03 | | Release date: | 2020-10-21 | | Last modified: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Cell, 183, 2020
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6TM6
 | | MUC2 CysD1 domain | | Descriptor: | CALCIUM ION, Mucin-2 | | Authors: | Khmelnitsky, L, Fass, D. | | Deposit date: | 2019-12-03 | | Release date: | 2020-02-19 | | Last modified: | 2021-03-03 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Cell, 183, 2020
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7O3I
 | | Cystal structure of Zymogen Granule Protein 16 (ZG16) | | Descriptor: | CHLORIDE ION, GLYCEROL, Zymogen granule membrane protein 16 | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-04-01 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
Febs J., 288, 2021
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7O4P
 | | Cystal structure of Zymogen Granule Protein 16 (ZG16) | | Descriptor: | CHLORIDE ION, GLYCEROL, Zymogen granule membrane protein 16 | | Authors: | Javitt, G, Fass, D. | | Deposit date: | 2021-04-07 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
Febs J., 288, 2021
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7O88
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1LCS
 | | RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS | | Descriptor: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Barnett, A.L, Wensel, D.L, Li, W, Fass, D, Cunningham, J.M. | | Deposit date: | 2002-04-06 | | Release date: | 2003-04-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Mechanism of a Coreceptor for Infection by a pathogenic feline retrovirus
J.Virol., 77, 2003
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1JRA
 | | Crystal Structure of Erv2p | | Descriptor: | ERV2 PROTEIN, MITOCHONDRIAL, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Gross, E, Sevier, C.S, Vala, A, Kaiser, C.A, Fass, D. | | Deposit date: | 2001-08-13 | | Release date: | 2001-12-28 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p.
Nat.Struct.Biol., 9, 2002
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1JR8
 | | Crystal Structure of Erv2p | | Descriptor: | Erv2 PROTEIN, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Gross, E, Sevier, C.S, Vala, A, Kaiser, C.A, Fass, D. | | Deposit date: | 2001-08-13 | | Release date: | 2001-12-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p.
Nat.Struct.Biol., 9, 2002
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