1A31
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![BU of 1a31 by Molmil](/molmil-images/mine/1a31) | HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I) | Authors: | Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G.J. | Deposit date: | 1998-01-27 | Release date: | 1998-08-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1998
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1A5C
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![BU of 1a5c by Molmil](/molmil-images/mine/1a5c) | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM | Descriptor: | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE | Authors: | Kim, H, Certa, U, Dobeli, H, Jakob, P, Hol, W.G.J. | Deposit date: | 1998-02-13 | Release date: | 1998-06-10 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of fructose-1,6-bisphosphate aldolase from the human malaria parasite Plasmodium falciparum. Biochemistry, 37, 1998
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3SOL
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![BU of 3sol by Molmil](/molmil-images/mine/3sol) | |
1AG1
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![BU of 1ag1 by Molmil](/molmil-images/mine/1ag1) | |
1HCY
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![BU of 1hcy by Molmil](/molmil-images/mine/1hcy) | |
1A36
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![BU of 1a36 by Molmil](/molmil-images/mine/1a36) | TOPOISOMERASE I/DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I | Authors: | Stewart, L, Redinbo, M.R, Qiu, X, Champoux, J.J, Hol, W.G.J. | Deposit date: | 1998-01-29 | Release date: | 1998-08-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A model for the mechanism of human topoisomerase I. Science, 279, 1998
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16PK
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![BU of 16pk by Molmil](/molmil-images/mine/16pk) | PHOSPHOGLYCERATE KINASE FROM TRYPANOSOMA BRUCEI BISUBSTRATE ANALOG | Descriptor: | 1,1,5,5-TETRAFLUOROPHOSPHOPENTYLPHOSPHONIC ACID ADENYLATE ESTER, 3-PHOSPHOGLYCERATE KINASE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | Authors: | Bernstein, B.E, Bressi, J, Blackburn, M, Gelb, M, Hol, W.G.J. | Deposit date: | 1998-05-18 | Release date: | 1998-11-25 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. J.Mol.Biol., 279, 1998
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3TGH
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![BU of 3tgh by Molmil](/molmil-images/mine/3tgh) | GAP50 the anchor in the inner membrane complex of Plasmodium | Descriptor: | COBALT (II) ION, DIMETHYL SULFOXIDE, Glideosome-associated protein 50, ... | Authors: | Bosch, J, Paige, M.H, Vaidya, A, Bergman, L, Hol, W.G.J. | Deposit date: | 2011-08-17 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. J.Struct.Biol., 178, 2012
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1JYM
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![BU of 1jym by Molmil](/molmil-images/mine/1jym) | Crystals of Peptide Deformylase from Plasmodium falciparum with Ten Subunits per Asymmetric Unit Reveal Critical Characteristics of the Active Site for Drug Design | Descriptor: | COBALT (II) ION, Peptide Deformylase | Authors: | Kumar, A, Nguyen, K.T, Srivathsan, S, Ornstein, B, Turley, S, Hirsh, I, Pei, D, Hol, W.G.J. | Deposit date: | 2001-09-12 | Release date: | 2002-03-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design. Structure, 10, 2002
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1DPB
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![BU of 1dpb by Molmil](/molmil-images/mine/1dpb) | |
1DPD
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![BU of 1dpd by Molmil](/molmil-images/mine/1dpd) | |
1DPC
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![BU of 1dpc by Molmil](/molmil-images/mine/1dpc) | |
1S5B
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![BU of 1s5b by Molmil](/molmil-images/mine/1s5b) | Cholera holotoxin with an A-subunit Y30S mutation Form 3 | Descriptor: | Cholera enterotoxin, A chain precursor, SODIUM ION, ... | Authors: | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | Deposit date: | 2004-01-20 | Release date: | 2004-04-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Crystal structures of an intrinsically active cholera toxin mutant yield
insight into the toxin activation mechanism Biochemistry, 43, 2004
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2QV8
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![BU of 2qv8 by Molmil](/molmil-images/mine/2qv8) | |
2RET
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![BU of 2ret by Molmil](/molmil-images/mine/2ret) | The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the Type 2 Secretion System of Vibrio vulnificus | Descriptor: | CHLORIDE ION, EpsJ, Pseudopilin EpsI, ... | Authors: | Yanez, M.E, Korotkov, K.V, Abendroth, J, Hol, W.G.J. | Deposit date: | 2007-09-27 | Release date: | 2008-02-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus. J.Mol.Biol., 375, 2008
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1SVH
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![BU of 1svh by Molmil](/molmil-images/mine/1svh) | Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8 | Descriptor: | (3R,4S)-N-(4-{TRANS-2-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-PHENYL]-VINYL}-AZEPAN-3-YL)-ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | Authors: | Breitenlechner, C.B, Wegge, T, Berillon, L, Graul, K, Marzenell, K, Friebe, W.G, Thomas, U, Schumacher, R, Huber, R, Engh, R.A, Masjost, B. | Deposit date: | 2004-03-29 | Release date: | 2005-03-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based optimization of novel azepane derivatives as PKB inhibitors J.Med.Chem., 47, 2004
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2TEC
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![BU of 2tec by Molmil](/molmil-images/mine/2tec) | MOLECULAR DYNAMICS REFINEMENT OF A THERMITASE-EGLIN-C COMPLEX AT 1.98 ANGSTROMS RESOLUTION AND COMPARISON OF TWO CRYSTAL FORMS THAT DIFFER IN CALCIUM CONTENT | Descriptor: | CALCIUM ION, EGLIN C, THERMITASE | Authors: | Gros, P, Betzel, C, Dauter, Z, Wilson, K.S, Hol, W.G.J. | Deposit date: | 1990-10-26 | Release date: | 1992-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content. J.Mol.Biol., 210, 1989
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1S5E
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![BU of 1s5e by Molmil](/molmil-images/mine/1s5e) | Cholera holotoxin, Crystal form 1 | Descriptor: | Cholera enterotoxin, A chain precursor, SODIUM ION, ... | Authors: | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | Deposit date: | 2004-01-20 | Release date: | 2004-04-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of an intrinsically active cholera toxin mutant yield
insight into the toxin activation mechanism Biochemistry, 43, 2004
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1R49
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![BU of 1r49 by Molmil](/molmil-images/mine/1r49) | Human topoisomerase I (Topo70) double mutant K532R/Y723F | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | Authors: | Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. | Deposit date: | 2003-10-03 | Release date: | 2003-12-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279, 2004
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2VMB
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![BU of 2vmb by Molmil](/molmil-images/mine/2vmb) | The three-dimensional structure of the cytoplasmic domains of EpsF from the Type 2 Secretion System of Vibrio cholerae | Descriptor: | CALCIUM ION, GENERAL SECRETION PATHWAY PROTEIN F | Authors: | Abendroth, J, Korotkov, K.V, Mitchell, D.D, Kreger, A, Hol, W.G.J. | Deposit date: | 2008-01-25 | Release date: | 2009-02-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Three-Dimensional Structure of the Cytoplasmic Domains of Epsf from the Type 2 Secretion System of Vibrio Cholerae. J.Struct.Biol., 166, 2009
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2VMA
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![BU of 2vma by Molmil](/molmil-images/mine/2vma) | The three-dimensional structure of the cytoplasmic domains of EpsF from the Type 2 Secretion System of Vibrio cholerae | Descriptor: | CALCIUM ION, GENERAL SECRETION PATHWAY PROTEIN F, IODIDE ION | Authors: | Abendroth, J, Korotkov, K.V, Mitchell, D.D, Kreger, A, Hol, W.G.J. | Deposit date: | 2008-01-25 | Release date: | 2009-02-10 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Three-Dimensional Structure of the Cytoplasmic Domains of Epsf from the Type 2 Secretion System of Vibrio Cholerae. J.Struct.Biol., 166, 2009
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1R59
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![BU of 1r59 by Molmil](/molmil-images/mine/1r59) | Enterococcus casseliflavus glycerol kinase | Descriptor: | Glycerol kinase | Authors: | Yeh, J.I, Charrier, V, Paulo, J, Hou, L, Darbon, E, Claiborne, A, Hol, W.G, Deutscher, J. | Deposit date: | 2003-10-09 | Release date: | 2004-10-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of conformation to substrate binding and a mechanism of activation by phosphorylation Biochemistry, 43, 2004
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1RDP
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![BU of 1rdp by Molmil](/molmil-images/mine/1rdp) | Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV3 | Descriptor: | 1,3-BIS-([[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBU TENYL]-AMINO-ETHYL]-AMINO-CARBONYLOXY)-2-AMINO-PROPANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, TRIETHYLENE GLYCOL, ... | Authors: | Pickens, J.C, Mitchell, D.D, Liu, J, Tan, X, Zhang, Z, Verlinde, C.L, Hol, W.G, Fan, E. | Deposit date: | 2003-11-05 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem.Biol., 11, 2004
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1S5F
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![BU of 1s5f by Molmil](/molmil-images/mine/1s5f) | Cholera holotoxin, Crystal form 2 | Descriptor: | Cholera enterotoxin, A chain, SODIUM ION, ... | Authors: | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | Deposit date: | 2004-01-20 | Release date: | 2004-04-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism Biochemistry, 43, 2004
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1S5C
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![BU of 1s5c by Molmil](/molmil-images/mine/1s5c) | Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1 | Descriptor: | Cholera enterotoxin, A chain, SODIUM ION, ... | Authors: | O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G. | Deposit date: | 2004-01-20 | Release date: | 2004-04-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of an intrinsically active cholera toxin mutant yield
insight into the toxin activation mechanism Biochemistry, 43, 2004
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