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5EEN
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BU of 5een by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with belinostat
Descriptor: Belinostat, CHLORIDE ION, Hdac6 protein, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.861 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EFK
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BU of 5efk by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (Y745F mutant) in complex with alpha tubulin K40 tripeptide substrate
Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, DI(HYDROXYETHYL)ETHER, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EEF
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BU of 5eef by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 in complex with trichostatin A
Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, HDAC6, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-22
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EFH
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BU of 5efh by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Descriptor: 1,2-ETHANEDIOL, 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, BROMIDE ION, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EF7
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BU of 5ef7 by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HPOB
Descriptor: 4-[2-[2-hydroxyethyl(phenyl)amino]-2-oxidanylidene-ethyl]-~{N}-oxidanyl-benzamide, Hdac6 protein, POTASSIUM ION, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EFN
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BU of 5efn by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (H574A) in complex with histone H4 Lys6 tripeptide substrate
Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, Hdac6 protein, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-24
Release date:2016-07-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
3MFW
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BU of 3mfw by Molmil
Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate
Descriptor: 2-amino-L-histidine, Arginase-1, MANGANESE (II) ION, ...
Authors:Di Costanzo, L, Christianson, D.W.
Deposit date:2010-04-04
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
J.Med.Chem., 53, 2010
5ERO
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BU of 5ero by Molmil
Crystal structure of elongation domain of Phomopsis amygdali fusicoccadiene synthase complexed with cobalt ions and pamidronate
Descriptor: COBALT (II) ION, Fusicoccadiene synthase, PAMIDRONATE
Authors:Chen, M, Christianson, D.W.
Deposit date:2015-11-14
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5EEI
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BU of 5eei by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with SAHA
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-22
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EFG
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BU of 5efg by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with acetate
Descriptor: ACETATE ION, Hdac6 protein, POTASSIUM ION, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
3LGK
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BU of 3lgk by Molmil
D99N Epi-isozizaene synthase
Descriptor: Epi-isozizaene synthase, SULFATE ION
Authors:Aaron, J.A, Lin, X, Cane, D.E, Christianson, D.W.
Deposit date:2010-01-20
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates
Biochemistry, 49, 2010
3LP7
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BU of 3lp7 by Molmil
Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution
Descriptor: Arginase-1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE
Authors:Di Costanzo, L, Christianson, D.W.
Deposit date:2010-02-04
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Inhibition of human arginase I by substrate and product analogues.
Arch.Biochem.Biophys., 496, 2010
2O3Z
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BU of 2o3z by Molmil
X-ray crystal structure of LpxC complexed with 3-heptyloxybenzoate
Descriptor: 3-(heptyloxy)benzoic acid, CHLORIDE ION, SULFATE ION, ...
Authors:Gennadios, H.A, Whittington, D.A, Christianson, D.W.
Deposit date:2006-12-02
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.
Bioorg.Med.Chem., 15, 2007
5EF8
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BU of 5ef8 by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Hdac6 protein, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5EEM
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BU of 5eem by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2
Descriptor: FORMIC ACID, Hdac6 protein, POTASSIUM ION, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
3MMR
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BU of 3mmr by Molmil
Structure of Plasmodium falciparum Arginase in complex with ABH
Descriptor: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase, BETA-MERCAPTOETHANOL, ...
Authors:Dowling, D.P, Ilies, M, Olszewski, K.L, Portugal, S, Mota, M.M, Llinas, M, Christianson, D.W.
Deposit date:2010-04-20
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection .
Biochemistry, 49, 2010
5ER8
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BU of 5er8 by Molmil
Crystal structure of cyclization domain of Phomopsis amygdali fusicoccadiene synthase complexed with manganese ions and neridronate
Descriptor: (6-azanyl-1-oxidanyl-1-phosphono-hexyl)phosphonic acid, CHLORIDE ION, Fusicoccadiene synthase, ...
Authors:Chen, M, Christianson, D.W.
Deposit date:2015-11-13
Release date:2016-01-20
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5EFJ
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BU of 5efj by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HC toxin
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, HC toxin, ...
Authors:Hai, Y, Christianson, D.W.
Deposit date:2015-10-23
Release date:2016-07-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
Nat.Chem.Biol., 12, 2016
5DC8
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BU of 5dc8 by Molmil
Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate
Descriptor: Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ...
Authors:Decroos, C, Lee, M.S, Christianson, D.W.
Deposit date:2015-08-23
Release date:2016-02-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
3KV2
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BU of 3kv2 by Molmil
HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR N(omega)-hydroxy-nor-L-arginine (nor-NOHA)
Descriptor: Arginase-1, MANGANESE (II) ION, NOR-N-OMEGA-HYDROXY-L-ARGININE
Authors:Di Costanzo, L, Christianson, D.W.
Deposit date:2009-11-28
Release date:2009-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Inhibition of human arginase I by substrate and product analogues.
Arch.Biochem.Biophys., 496, 2010
2RLA
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BU of 2rla by Molmil
ALTERING THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE DIMINISHES THERMOSTABILITY AND CATALYTIC FUNCTION
Descriptor: ARGINASE, MANGANESE (II) ION
Authors:Scolnick, L.R, Kanyo, Z.F, Christianson, D.W.
Deposit date:1997-05-07
Release date:1998-05-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
Biochemistry, 36, 1997
2PS6
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BU of 2ps6 by Molmil
N225D/S229T trichodiene synthase
Descriptor: 1,2-ETHANEDIOL, Trichodiene synthase
Authors:Vedula, L.S, Cane, D.E, Christianson, D.W.
Deposit date:2007-05-04
Release date:2007-12-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.
Arch.Biochem.Biophys., 469, 2008
3N0F
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BU of 3n0f by Molmil
Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens)
Descriptor: Isoprene synthase
Authors:Koksal, M, Christianson, D.W.
Deposit date:2010-05-13
Release date:2010-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission.
J.Mol.Biol., 402, 2010
3MZ3
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BU of 3mz3 by Molmil
Crystal structure of Co2+ HDAC8 complexed with M344
Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, Histone deacetylase 8, ...
Authors:Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010
3MZ4
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BU of 3mz4 by Molmil
Crystal structure of D101L Mn2+ HDAC8 complexed with M344
Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ...
Authors:Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W.
Deposit date:2010-05-11
Release date:2010-06-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
Biochemistry, 49, 2010

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