7X78
 
 | | L-fuculose 1-phosphate aldolase | | Descriptor: | L-fuculose phosphate aldolase, MAGNESIUM ION, SULFATE ION | | Authors: | Lou, X, Zhang, Q, Bartlam, M. | | Deposit date: | 2022-03-09 | | Release date: | 2022-04-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural characterization of an L-fuculose-1-phosphate aldolase from Klebsiella pneumoniae.
Biochem.Biophys.Res.Commun., 607, 2022
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8IJR
 | | The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine | | Descriptor: | (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1 | | Authors: | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | | Deposit date: | 2023-02-28 | | Release date: | 2024-02-28 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 31, 2024
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8IJQ
 | | The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide | | Descriptor: | N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, Sphingomyelin synthase-related protein 1 | | Authors: | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | | Deposit date: | 2023-02-27 | | Release date: | 2024-02-28 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 31, 2024
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7BVD
 | | Anthranilate synthase component I (TrpE)[Mycolicibacterium smegmatis] | | Descriptor: | Anthranilate synthase component 1, BENZOIC ACID, GLYCEROL, ... | | Authors: | Chen, Y, Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-04-10 | | Release date: | 2020-05-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of subunit I of the anthranilate synthase complex of Mycolicibacterium smegmatis
Biochem.Biophys.Res.Commun., 527, 2020
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7D9F
 | | SpdH Spermidine dehydrogenase SeMet Structure | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-10-13 | | Release date: | 2021-11-17 | | Last modified: | 2022-04-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.
Febs J., 289, 2022
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7D9I
 | | SpdH Spermidine dehydrogenase D282A mutant | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, PROTOPORPHYRIN IX CONTAINING FE, Spermidine dehydrogenase, ... | | Authors: | Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-10-13 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.
Febs J., 289, 2022
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7D9H
 | | SpdH Spermidine dehydrogenase N33 truncation structure | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-10-13 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.
Febs J., 289, 2022
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7D9G
 | | SpdH Spermidine dehydrogenase native structure | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, PROTOPORPHYRIN IX CONTAINING FE, Spermidine dehydrogenase, ... | | Authors: | Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-10-13 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.
Febs J., 289, 2022
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7D9J
 | | SpdH Spermidine dehydrogenase Y443A mutant | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Che, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2020-10-13 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.
Febs J., 289, 2022
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7DVQ
 | | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ... | | Authors: | Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y. | | Deposit date: | 2021-01-14 | | Release date: | 2021-03-31 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure of the activated human minor spliceosome.
Science, 371, 2021
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7E7G
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7E6K
 | | Viral protease | | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, N-(2-phenoxyethyl)methanethioamide, ... | | Authors: | Zhao, Y, Zhang, Q, Yang, H.T, Rao, Z.H. | | Deposit date: | 2021-02-22 | | Release date: | 2022-02-23 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Viral protease
To be published
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7EER
 | | Crystal structure of Tryptophanyl-tRNA synthetase from Bacillus stearothermophilus in complex with 05E6 and ATP | | Descriptor: | 2-(1H-indol-3-yl)ethanol, ADENOSINE-5'-TRIPHOSPHATE, Tryptophan--tRNA ligase | | Authors: | Lv, G, Fan, S, Feng, X, Zhang, Q, Wu, G, Jin, Y, Yang, Z. | | Deposit date: | 2021-03-19 | | Release date: | 2022-05-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of Tryptophanyl-tRNA synthetase from Bacillus stearothermophilus in complex with O5E6 and ATP
To Be Published
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7XNJ
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7XFT
 | | MucP PDZ2 domain | | Descriptor: | Putative zinc metalloprotease PA3649, SODIUM ION, VALINE | | Authors: | Lou, X, Li, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2022-04-02 | | Release date: | 2023-04-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | MucP PDZ2 domain
To Be Published
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7XFU
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7XFS
 | | MucP PDZ1 domain | | Descriptor: | Putative zinc metalloprotease PA3649 | | Authors: | Lou, X, Li, S, Zhang, Q, Bartlam, M. | | Deposit date: | 2022-04-02 | | Release date: | 2023-04-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | MucP PDZ1 domain
To Be Published
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7YIV
 | | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | Authors: | Cao, Y, Qin, A, Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y. | | Deposit date: | 2022-07-18 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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7Y0Z
 | | Crystal structure of Pseudomonas aeruginosa PvrA | | Descriptor: | TetR family transcriptional regulator | | Authors: | Liang, H, Zhang, Q, Bartlam, M. | | Deposit date: | 2022-06-06 | | Release date: | 2023-02-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa.
Nucleic Acids Res., 51, 2023
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7Y0Y
 | | Crystal structure of Pseudomonas aeruginosa PvrA (SeMet) | | Descriptor: | TetR family transcriptional regulator | | Authors: | Liang, H, Zhang, Q, Bartlam, M. | | Deposit date: | 2022-06-06 | | Release date: | 2023-02-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa.
Nucleic Acids Res., 51, 2023
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7YIW
 | | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Cao, Y. | | Deposit date: | 2022-07-18 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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7YIX
 | | The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Ma, P.X, Cao, Y. | | Deposit date: | 2022-07-18 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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1NX7
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6LJA
 | | Crystal Structure of exoHep from Bacteroides intestinalis DSM 17393 complexed with disaccharide product | | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | | Authors: | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | | Deposit date: | 2019-12-13 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.978 Å) | | Cite: | Discovery of exolytic heparinases and their catalytic mechanism and potential application.
Nat Commun, 12, 2021
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6LJL
 | | Crystal Structure of exoHep-Y390A/H555A complexed with a tetrasaccharide substrate | | Descriptor: | 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | | Authors: | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | | Deposit date: | 2019-12-17 | | Release date: | 2020-12-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Discovery of exolytic heparinases and their catalytic mechanism and potential application.
Nat Commun, 12, 2021
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