4XVK
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![BU of 4xvk by Molmil](/molmil-images/mine/4xvk) | Binary complex of human polymerase nu and DNA with the finger domain closed | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ... | Authors: | Lee, Y.-S, Yang, W. | Deposit date: | 2015-01-27 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat.Struct.Mol.Biol., 22, 2015
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4XVL
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![BU of 4xvl by Molmil](/molmil-images/mine/4xvl) | Binary complex of human polymerase nu and DNA with the finger domain open | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ... | Authors: | Lee, Y.-S, Yang, W. | Deposit date: | 2015-01-27 | Release date: | 2015-03-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat.Struct.Mol.Biol., 22, 2015
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6N7W
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![BU of 6n7w by Molmil](/molmil-images/mine/6n7w) | Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A)/Trx in complex with a DNA fork and incoming dTTP (from multiple lead complexes) | Descriptor: | DNA (25-MER), DNA (77-MER), DNA-directed DNA polymerase, ... | Authors: | Gao, Y, Fox, T, Val, N, Yang, W. | Deposit date: | 2018-11-28 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N9V
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![BU of 6n9v by Molmil](/molmil-images/mine/6n9v) | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS1) | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ... | Authors: | Gao, Y, Fox, T, Val, N, Yang, W. | Deposit date: | 2018-12-04 | Release date: | 2019-03-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N7I
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![BU of 6n7i by Molmil](/molmil-images/mine/6n7i) | Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (gp4(5)-DNA) | Descriptor: | DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... | Authors: | Gao, Y, Cui, Y, Zhou, Z, Yang, W. | Deposit date: | 2018-11-27 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N9U
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![BU of 6n9u by Molmil](/molmil-images/mine/6n9u) | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase domains of two gp4 subunits bound to an RNA/DNA hybrid and dTTP (from LagS1) | Descriptor: | DNA (44-MER), DNA primase/helicase, DNA-directed DNA polymerase, ... | Authors: | Gao, Y, Fox, T, Val, N, Yang, W. | Deposit date: | 2018-12-04 | Release date: | 2019-03-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N9X
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![BU of 6n9x by Molmil](/molmil-images/mine/6n9x) | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS3) | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ... | Authors: | Gao, Y, Fox, T, Val, N, Yang, W. | Deposit date: | 2018-12-04 | Release date: | 2019-03-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N7T
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![BU of 6n7t by Molmil](/molmil-images/mine/6n7t) | Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form III) | Descriptor: | DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... | Authors: | Gao, Y, Cui, Y, Zhou, Z, Yang, W. | Deposit date: | 2018-11-28 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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4WWX
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![BU of 4wwx by Molmil](/molmil-images/mine/4wwx) | Crystal structure of the core RAG1/2 recombinase | Descriptor: | V(D)J recombination-activating protein 1, V(D)J recombination-activating protein 2, ZINC ION | Authors: | Kim, M.S, Lapkouski, M, Yang, W, Gellert, M. | Deposit date: | 2014-11-12 | Release date: | 2015-02-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2001 Å) | Cite: | Crystal structure of the V(D)J recombinase RAG1-RAG2. Nature, 518, 2015
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7BVV
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![BU of 7bvv by Molmil](/molmil-images/mine/7bvv) | Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 | Descriptor: | Peroxiredoxin AHP1, Thioredoxin-2 | Authors: | Lian, F.M, Jiang, Y.L, Yang, W, Yang, X. | Deposit date: | 2020-04-11 | Release date: | 2020-07-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle. Int.J.Biol.Macromol., 161, 2020
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6WYA
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![BU of 6wya by Molmil](/molmil-images/mine/6wya) | RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W. | Deposit date: | 2020-05-12 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | How a B family DNA polymerase has been evolved to copy RNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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6N7S
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![BU of 6n7s by Molmil](/molmil-images/mine/6n7s) | Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form II) | Descriptor: | DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... | Authors: | Gao, Y, Cui, Y, Zhou, Z, Yang, W. | Deposit date: | 2018-11-28 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N7N
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![BU of 6n7n by Molmil](/molmil-images/mine/6n7n) | Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form I) | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA primase/helicase, MAGNESIUM ION, ... | Authors: | Gao, Y, Cui, Y, Zhou, Z, Yang, W. | Deposit date: | 2018-11-27 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N9W
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![BU of 6n9w by Molmil](/molmil-images/mine/6n9w) | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS2) | Descriptor: | DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ... | Authors: | Gao, Y, Cui, Y, Zhou, Z, Yang, W. | Deposit date: | 2018-12-04 | Release date: | 2019-03-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6N7V
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![BU of 6n7v by Molmil](/molmil-images/mine/6n7v) | Structure of bacteriophage T7 gp4 (helicase-primase, E343Q mutant) in complex with ssDNA, dTTP, AC dinucleotide, and CTP (from multiple lead complexes) | Descriptor: | DNA (93-MER), DNA primase/helicase, MAGNESIUM ION, ... | Authors: | Gao, Y, Fox, T, Val, N, Yang, W. | Deposit date: | 2018-11-28 | Release date: | 2019-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures and operating principles of the replisome. Science, 363, 2019
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6OEO
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![BU of 6oeo by Molmil](/molmil-images/mine/6oeo) | Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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6OEQ
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![BU of 6oeq by Molmil](/molmil-images/mine/6oeq) | Cryo-EM structure of mouse RAG1/2 12RSS-PRC/23RSS-NFC complex (DNA1) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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6WYB
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![BU of 6wyb by Molmil](/molmil-images/mine/6wyb) | RTX (Reverse Transcription Xenopolymerase) in complex with an RNA/DNA hybrid | Descriptor: | 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA polymerase, ... | Authors: | Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W. | Deposit date: | 2020-05-12 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | How a B family DNA polymerase has been evolved to copy RNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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6OER
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![BU of 6oer by Molmil](/molmil-images/mine/6oer) | Cryo-EM structure of mouse RAG1/2 NFC complex (DNA2) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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6OES
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![BU of 6oes by Molmil](/molmil-images/mine/6oes) | Cryo-EM structure of mouse RAG1/2 STC complex (without NBD domain) | Descriptor: | CALCIUM ION, DNA (34-MER), DNA (35-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | How mouse RAG recombinase avoids DNA transposition. Nat.Struct.Mol.Biol., 27, 2020
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8EBU
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![BU of 8ebu by Molmil](/molmil-images/mine/8ebu) | XPC release from Core7-XPA-DNA (Cy5) | Descriptor: | DNA repair protein complementing XP-A cells, DNA repair protein complementing XP-C cells, DNA1, ... | Authors: | Kim, J, Yang, W. | Deposit date: | 2022-08-31 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
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8EBS
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![BU of 8ebs by Molmil](/molmil-images/mine/8ebs) | |
8EBT
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![BU of 8ebt by Molmil](/molmil-images/mine/8ebt) | |
8EBY
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![BU of 8eby by Molmil](/molmil-images/mine/8eby) | XPC release from Core7-XPA-DNA (AP) | Descriptor: | DNA, DNA repair protein complementing XP-A cells, DNA repair protein complementing XP-C cells, ... | Authors: | Kim, J, Yang, W. | Deposit date: | 2022-08-31 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
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8EBV
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![BU of 8ebv by Molmil](/molmil-images/mine/8ebv) | |