5EFZ
 
 | | Monoclinic structure of the acetyl esterase MekB | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ... | | 著者 | Toelzer, C, Pal, S, Watzlawick, H, Altenbuchner, J, Niefind, K. | | 登録日 | 2015-10-26 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
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6ZB5
 | | SARS CoV-2 Spike protein, Closed conformation, C3 symmetry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Burucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2020-06-07 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
Science, 370, 2020
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6ZB4
 | | SARS CoV-2 Spike protein, Closed conformation, C1 symmetry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Burucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2020-06-06 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
Science, 370, 2020
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7ZH2
 | | SARS CoV Spike protein, Closed C1 conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Buzas, D, Borucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2022-04-05 | | 公開日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | The free fatty acid-binding pocket is a conserved hallmark in pathogenic beta-coronavirus spike proteins from SARS-CoV to Omicron.
Sci Adv, 8, 2022
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7ZH5
 | | SARS CoV Spike protein, Open conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Buzas, D, Borucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2022-04-05 | | 公開日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The free fatty acid-binding pocket is a conserved hallmark in pathogenic beta-coronavirus spike proteins from SARS-CoV to Omicron.
Sci Adv, 8, 2022
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7ZH1
 | | SARS CoV Spike protein, Closed C3 conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Buzas, D, Borucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2022-04-05 | | 公開日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | | 主引用文献 | The free fatty acid-binding pocket is a conserved hallmark in pathogenic beta-coronavirus spike proteins from SARS-CoV to Omicron.
Sci Adv, 8, 2022
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7ODL
 | | SARS CoV-2 Spike protein, Bristol UK Deletion variant, Closed conformation, C1 symmetry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Borucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2021-04-29 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2.
Nat Commun, 13, 2022
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7OD3
 | | SARS CoV-2 Spike protein, Bristol UK Deletion variant, Closed conformation, C3 symmetry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein | | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Borucu, U, Schaffitzel, C, Berger, I. | | 登録日 | 2021-04-28 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2.
Nat Commun, 13, 2022
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5D7B
 | | Trigonal Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum | | 分子名称: | GLYCEROL, Homoserine O-acetyltransferase | | 著者 | Niefind, K, Toelzer, C, Pal, S, Altenbuchner, J, Watzlawick, H. | | 登録日 | 2015-08-13 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
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5D6O
 | | Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum | | 分子名称: | CHLORIDE ION, GLYCEROL, Homoserine O-acetyltransferase, ... | | 著者 | Niefind, K, Toelzer, C, Altenbuchner, J, Watzlawick, H. | | 登録日 | 2015-08-12 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
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5E4Y
 | | Orthorhombic structure of the acetyl esterase MekB | | 分子名称: | Homoserine O-acetyltransferase | | 著者 | Niefind, K, Toelzer, C, Pal, S, Watzlawick, H, Altenbuchner, J. | | 登録日 | 2015-10-07 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
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6ZDZ
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6ZE0
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4IOI
 | | Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC | | 分子名称: | Immunoglobulin G-binding protein A, Protein L, Trastuzumab heavy chain, ... | | 著者 | Bzymek, K.P, Zer, C, Avery, K.N, Williams, J.C. | | 登録日 | 2013-01-07 | | 公開日 | 2013-10-09 | | 最終更新日 | 2013-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GW1
 | | cQFD Meditope | | 分子名称: | Fab heavy chain, Fab light chain, PHOSPHATE ION, ... | | 著者 | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | 登録日 | 2012-08-31 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GW5
 | | cQYN meditope - Cetuximab Fab | | 分子名称: | Fab Heavy Chain, Fab Light Chain, PHOSPHATE ION, ... | | 著者 | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | 登録日 | 2012-08-31 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HJG
 | | Meditope-enabled trastuzumab | | 分子名称: | Immunoglobulin G-binding protein A, Protein L fragment, Trastuzumab heavy chain, ... | | 著者 | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | 登録日 | 2012-10-12 | | 公開日 | 2013-10-09 | | 最終更新日 | 2013-11-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HKZ
 | | Trastuzumab Fab complexed with Protein L and Protein A fragments | | 分子名称: | CHLORIDE ION, Immunoglobulin G-binding protein A, Protein L fragment, ... | | 著者 | Avery, K.N, Zer, C, Bzymek, K.P, Williams, J.C. | | 登録日 | 2012-10-15 | | 公開日 | 2013-10-09 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5U5F
 | | MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK | | 分子名称: | 5-DIPHENYL LONG MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, ... | | 著者 | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | 登録日 | 2016-12-06 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Meditope Enabled Trastuzumab I83E Variant In Complex With (Ac)Cqfda(Ph)2Strrlrcggsk
To Be Published
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5U5M
 | | CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE | | 分子名称: | AZIDO-PEG4-MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB, ... | | 著者 | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | | 登録日 | 2016-12-06 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-Meditope
To Be Published
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5U3D
 | | STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT | | 分子名称: | Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, MEMAB TRASTUZUMAB FAB LIGHT CHAIN I83E, ... | | 著者 | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | 登録日 | 2016-12-01 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Meditope Enabled Trastuzumab I83E Variant
To Be Published
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5U6A
 | | CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-PEG3-MEDITOPE | | 分子名称: | Heavy Chain, Immunoglobulin G binding protein A, Light Chain, ... | | 著者 | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | | 登録日 | 2016-12-07 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.736 Å) | | 主引用文献 | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-PEG3-Meditope
To Be Published
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7A22
 | | Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine | | 分子名称: | 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha' | | 著者 | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | | 登録日 | 2020-08-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.01 Å) | | 主引用文献 | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
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7A4B
 | | Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6-dibromo-1H-triazolo[4,5-b]pyridine | | 分子名称: | 5,6-dibromo-1H-triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... | | 著者 | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | | 登録日 | 2020-08-19 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
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7A2H
 | | Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-imidazo[4,5-b]pyridine | | 分子名称: | 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-imidazo[4,5-b]pyridine, Casein kinase II subunit alpha' | | 著者 | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | | 登録日 | 2020-08-18 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.01 Å) | | 主引用文献 | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.
Bioorg.Chem., 106, 2021
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