5WOB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wob by Molmil](/molmil-images/mine/5wob) | Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin | 分子名称: | IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... | 著者 | McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. | 登録日 | 2017-08-01 | 公開日 | 2018-04-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
9CYO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9cyo by Molmil](/molmil-images/mine/9cyo) | Crystal structure of wild-type human PTP1B (PTPN1) at room temperature (298 K) | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | 登録日 | 2024-08-02 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024
|
|
9CYP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9cyp by Molmil](/molmil-images/mine/9cyp) | Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K) | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | 登録日 | 2024-08-02 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024
|
|
9CYQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9cyq by Molmil](/molmil-images/mine/9cyq) | Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K) | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | 登録日 | 2024-08-02 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024
|
|
9CYR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9cyr by Molmil](/molmil-images/mine/9cyr) | Crystal structure of D245G mutant human PTP1B (PTPN1) at room temperature (298 K) | 分子名称: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | 登録日 | 2024-08-02 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024
|
|
6B70
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b70 by Molmil](/molmil-images/mine/6b70) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin | 分子名称: | FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-03 | 公開日 | 2017-12-27 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6BF8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bf8 by Molmil](/molmil-images/mine/6bf8) | Cryo-EM structure of human insulin degrading enzyme in complex with insulin | 分子名称: | Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-26 | 公開日 | 2018-04-04 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6B7Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b7y by Molmil](/molmil-images/mine/6b7y) | Cryo-EM structure of human insulin degrading enzyme | 分子名称: | Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-05 | 公開日 | 2017-11-08 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6BFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bfc by Molmil](/molmil-images/mine/6bfc) | Cryo-EM structure of human insulin degrading enzyme in complex with insulin | 分子名称: | Insulin, Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-26 | 公開日 | 2017-12-27 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6BF6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bf6 by Molmil](/molmil-images/mine/6bf6) | Cryo-EM structure of human insulin degrading enzyme | 分子名称: | Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-26 | 公開日 | 2018-02-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6B3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b3q by Molmil](/molmil-images/mine/6b3q) | Cryo-EM structure of human insulin degrading enzyme in complex with insulin | 分子名称: | Insulin, Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-09-22 | 公開日 | 2017-11-22 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6B7Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b7z by Molmil](/molmil-images/mine/6b7z) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain | 分子名称: | FAB H11 heavy chain, FAB H11 light chain, Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-05 | 公開日 | 2018-01-10 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6BF9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bf9 by Molmil](/molmil-images/mine/6bf9) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | 分子名称: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-26 | 公開日 | 2018-02-07 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|
6BF7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bf7 by Molmil](/molmil-images/mine/6bf7) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | 分子名称: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | 著者 | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | 登録日 | 2017-10-26 | 公開日 | 2018-02-07 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
|
|