4KO6
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4KOC
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4KOB
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4KO9
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![BU of 4ko9 by Molmil](/molmil-images/mine/4ko9) | |
4KO7
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4KO5
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![BU of 4ko5 by Molmil](/molmil-images/mine/4ko5) | Investigating the functional significance of the interlocked pair structural determinants in Pseudomonas aeruginosa azurin (V31I/W48L/V95I/Y108F) | 分子名称: | Azurin, COPPER (II) ION | 著者 | Inampudi, K.K, Wang, Y, Meng, W, Tobin, P.H, Wilson, C.J. | 登録日 | 2013-05-11 | 公開日 | 2014-05-14 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Investigating the functional significance of the interlocked pair structural determinants in Pseudomonas aeruginosa azurin (V31I/W48L/V95I/Y108F) To be Published
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2OSB
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![BU of 2osb by Molmil](/molmil-images/mine/2osb) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q16L/Q199R/) | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Myers, J, Counago, R, Wilson, C.J, Wu, G, Shamoo, Y. | 登録日 | 2007-02-05 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q16L/Q199R/) To be Published
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2P3S
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![BU of 2p3s by Molmil](/molmil-images/mine/2p3s) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R) | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Counago, R, Wilson, C.J, Myers, J, Wu, G, Shamoo, Y. | 登録日 | 2007-03-09 | 公開日 | 2008-01-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R) To be Published
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2ORI
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![BU of 2ori by Molmil](/molmil-images/mine/2ori) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (A193V/Q199R/) | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Counago, R, Shamoo, Y, Wilson, C.J, Wu, G, Myers, J. | 登録日 | 2007-02-02 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (A193V/Q199R/) To be Published
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2OO7
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![BU of 2oo7 by Molmil](/molmil-images/mine/2oo7) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R) | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Counago, R, Wilson, C.J, Wu, G, Myers, J.C, Wittung-Stafshede, P, Shamoo, Y. | 登録日 | 2007-01-25 | 公開日 | 2008-02-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R) To be Published
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2QAJ
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![BU of 2qaj by Molmil](/molmil-images/mine/2qaj) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q199R/G213E) | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | 著者 | Counago, R, Wilson, C.J, Myers, J, Wu, G, Shamoo, Y. | 登録日 | 2007-06-15 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q199R/G213E) To be Published
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4FN5
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8C9H
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![BU of 8c9h by Molmil](/molmil-images/mine/8c9h) | AQP7_inhibitor | 分子名称: | Aquaporin-7, ethyl 4-[(4-pyrazol-1-ylphenyl)methylcarbamoylamino]benzoate | 著者 | Huang, P, Venskutonyte, R, Gourdon, P, Lindkvist-Petersson, K. | 登録日 | 2023-01-22 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for human aquaporin inhibition. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SBJ
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![BU of 8sbj by Molmil](/molmil-images/mine/8sbj) | Co-structure Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform complexed with brain penetrant inhibitors | 分子名称: | (2M)-7-[(3R)-3-methylmorpholin-4-yl]-5-[(3S)-3-methylmorpholin-4-yl]-2-(1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Knapp, M.S, Elling, R.A, Tang, J. | 登録日 | 2023-04-03 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes. J.Med.Chem., 66, 2023
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8SBC
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![BU of 8sbc by Molmil](/molmil-images/mine/8sbc) | Co-structure of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and brain penetrant inhibitors | 分子名称: | (2M)-7-[(3R)-3-methylmorpholin-4-yl]-5-[(3S)-3-methylmorpholin-4-yl]-2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Knapp, M.S, Elling, R.A, Tang, J. | 登録日 | 2023-04-03 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes. J.Med.Chem., 66, 2023
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4PH4
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![BU of 4ph4 by Molmil](/molmil-images/mine/4ph4) | The crystal structure of Human VPS34 in complex with PIK-III | 分子名称: | 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3 | 著者 | Knapp, M.S, Elling, R.A. | 登録日 | 2014-05-04 | 公開日 | 2014-10-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat.Cell Biol., 16, 2014
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3SD5
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![BU of 3sd5 by Molmil](/molmil-images/mine/3sd5) | Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine | 分子名称: | 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Knapp, M.S, Elling, R.A. | 登録日 | 2011-06-08 | 公開日 | 2012-01-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor. Mol.Cancer Ther., 11, 2012
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