1BSH
 
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1BSN
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2A7U
 | | NMR solution structure of the E.coli F-ATPase delta subunit N-terminal domain in complex with alpha subunit N-terminal 22 residues | | 分子名称: | ATP synthase alpha chain, ATP synthase delta chain | | 著者 | Wilkens, S, Borchardt, D, Weber, J, Senior, A.E. | | 登録日 | 2005-07-06 | | 公開日 | 2005-10-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of the Interaction of the delta and alpha Subunits of the Escherichia coli F(1)F(0)-ATP Synthase by NMR Spectroscopy
Biochemistry, 44, 2005
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1ABV
 | | N-TERMINAL DOMAIN OF THE DELTA SUBUNIT OF THE F1F0-ATP SYNTHASE FROM ESCHERICHIA COLI, NMR, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | DELTA SUBUNIT OF THE F1F0-ATP SYNTHASE | | 著者 | Wilkens, S, Dunn, S.D, Chandler, J, Dahlquist, F.W, Capaldi, R.A. | | 登録日 | 1997-01-29 | | 公開日 | 1997-07-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the N-terminal domain of the delta subunit of the E. coli ATPsynthase.
Nat.Struct.Biol., 4, 1997
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4AKM
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2GBG
 | | rat DPP-IV with alkynyl cyanopyrrolidine #2 | | 分子名称: | (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE, Dipeptidyl peptidase 4, SULFATE ION | | 著者 | Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. | | 登録日 | 2006-03-10 | | 公開日 | 2006-07-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
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2GBI
 | | rat DPP-IV with xanthine inhibitor 4 | | 分子名称: | 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE, Dipeptidyl peptidase 4 | | 著者 | Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. | | 登録日 | 2006-03-10 | | 公開日 | 2006-07-04 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
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2GBF
 | | rat dpp-IV with alkynyl cyanopyrrolidine #1 | | 分子名称: | (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE, Dipeptidyl peptidase 4 | | 著者 | Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. | | 登録日 | 2006-03-10 | | 公開日 | 2006-07-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
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2GBC
 | | Native DPP-IV (CD26) from Rat | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 | | 著者 | Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. | | 登録日 | 2006-03-10 | | 公開日 | 2006-07-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
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5BW9
 | | Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form | | 分子名称: | V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit D, ... | | 著者 | Oot, R.A, Kane, P.M, Berry, E.A, Wilkens, S. | | 登録日 | 2015-06-06 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (7 Å) | | 主引用文献 | Crystal structure of yeast V1-ATPase in the autoinhibited state.
Embo J., 35, 2016
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7FDA
 | | CryoEM Structure of Reconstituted V-ATPase, state1 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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7FDB
 | | CryoEM Structures of Reconstituted V-ATPase,State2 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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7FDC
 | | CryoEM Structures of Reconstituted V-ATPase, state3 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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7FDE
 | | CryoEM Structures of Reconstituted V-ATPase, Oxr1 bound V1 | | 分子名称: | Oxidation resistance protein 1, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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6C6L
 | | Yeast Vacuolar ATPase Vo in lipid nanodisc | | 分子名称: | V-type proton ATPase subunit a, vacuolar isoform, V-type proton ATPase subunit c, ... | | 著者 | Roh, S, Stam, N.J, Hryc, C, Couoh-Cardel, S, Pintilie, G, Chiu, W, Wilkens, S. | | 登録日 | 2018-01-19 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The 3.5- angstrom CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase VoProton Channel.
Mol. Cell, 69, 2018
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5D80
 | | Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form | | 分子名称: | V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit D, ... | | 著者 | Oot, R.A, Kane, P.M, Berry, E.A, Wilkens, S. | | 登録日 | 2015-08-14 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (6.202 Å) | | 主引用文献 | Crystal structure of yeast V1-ATPase in the autoinhibited state.
Embo J., 35, 2016
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4EFA
 | | Crystal Structure of the Heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase - second conformation | | 分子名称: | SULFATE ION, V-type proton ATPase subunit C, V-type proton ATPase subunit E, ... | | 著者 | Oot, R.A, Huang, L.S, Berry, E.A, Wilkens, S. | | 登録日 | 2012-03-29 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8163 Å) | | 主引用文献 | Crystal Structure of the Yeast Vacuolar ATPase Heterotrimeric EGC(head) Peripheral Stalk Complex.
Structure, 20, 2012
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6M0S
 | | 3.6A Yeast Vo state3 prime | | 分子名称: | Uncharacterized protein YPR170W-B, V-type proton ATPase subunit a, vacuolar isoform, ... | | 著者 | Roh, S.H, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, SIngharoy, A, Chiu, W. | | 登録日 | 2020-02-22 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex.
Sci Adv, 6, 2020
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6M0R
 | | 2.7A Yeast Vo state3 | | 分子名称: | (6~{E},10~{E},14~{E},18~{E},22~{E},26~{E},30~{R})-2,6,10,14,18,22,26,30-octamethyldotriaconta-2,6,10,14,18,22,26-heptaene, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, PYROPHOSPHATE, ... | | 著者 | Roh, S.H, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, Singharoy, A, Chiu, W. | | 登録日 | 2020-02-22 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex.
Sci Adv, 6, 2020
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4DL0
 | | Crystal Structure of the heterotrimeric EGChead Peripheral Stalk Complex of the Yeast Vacuolar ATPase | | 分子名称: | SULFATE ION, TRIMETHYL LEAD ION, V-type proton ATPase subunit C, ... | | 著者 | Oot, R.A, Huang, L.S, Berry, E.A, Wilkens, S. | | 登録日 | 2012-02-05 | | 公開日 | 2012-10-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.905 Å) | | 主引用文献 | Crystal Structure of the Yeast Vacuolar ATPase Heterotrimeric EGC(head) Peripheral Stalk Complex.
Structure, 20, 2012
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3G90
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3G9L
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3G9N
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9EWT
 | | Optimisation of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations | | 分子名称: | 1-[2-[3-[(E)-2-(5-cyclopropyl-1,3-oxazol-2-yl)ethenyl]phenyl]-3-pyridin-4-yl-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one, Epidermal growth factor receptor | | 著者 | Hargreaves, D. | | 登録日 | 2024-04-04 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.019 Å) | | 主引用文献 | Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J.Med.Chem., 2024
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7O83
 | | KRasG12C ligand complex | | 分子名称: | 1-[(7S)-11-chloro-12-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,15,17-tetrazatetracyclo[8.7.1.02,7.014,18]octadeca-1(17),10,12,14(18),15-pentaen-5-yl]prop-2-en-1-one, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Phillips, C, Breed, J. | | 登録日 | 2021-04-14 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-05-25 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
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