2GBF

rat dpp-IV with alkynyl cyanopyrrolidine #1

Summary for 2GBF

Related2GBC 2GBF 2GBG 2GBI
DescriptorDipeptidyl peptidase 4, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE (2 entities in total)
Functional Keywordsserine peptidase beta propeller, hydrolase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationDipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein P14740
Total number of polymer chains2
Total molecular weight168924.51
Authors
Longenecker, K.L.,Jakob, C.G.,Fry, E.H.,Wilk, S. (deposition date: 2006-03-10, release date: 2006-07-04, Last modification date: 2017-10-18)
Primary citation
Longenecker, K.L.,Stewart, K.D.,Madar, D.J.,Jakob, C.G.,Fry, E.H.,Wilk, S.,Lin, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Yong, H.,Pireh, D.,Pei, Z.,Basha, F.,Wiedeman, P.E.,Von Geldern, T.W.,Trevillyan, J.M.,Stoll, V.S.
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45:7474-7482, 2006
PubMed: 16768443 (PDB entries with the same primary citation)
DOI: 10.1021/bi060184f
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278253.7%7.9%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2gbf
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Molmil generated image of 2gbf
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Molmil generated image of 2gbf
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More Biological unit images

Molmil generated image of 2gbf
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Molmil generated image of 2gbf
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Molmil generated image of 2gbf
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2gbf.pdb1.gz [222.41 KB])
Coordinate files for Biological unit (2gbf.pdb2.gz [655.32 KB])