2GBC

Native DPP-IV (CD26) from Rat

Summary for 2GBC

DescriptorDipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ... (4 entities in total)
Functional Keywordsbeta propeller, hydrolase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationDipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein P14740
Total number of polymer chains2
Total molecular weight170887.24
Authors
Longenecker, K.L.,Jakob, C.G.,Fry, E.H.,Wilk, S. (deposition date: 2006-03-10, release date: 2006-07-04, Last modification date: 2017-10-18)
Primary citation
Longenecker, K.L.,Stewart, K.D.,Madar, D.J.,Jakob, C.G.,Fry, E.H.,Wilk, S.,Lin, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Yong, H.,Pireh, D.,Pei, Z.,Basha, F.,Wiedeman, P.E.,Von Geldern, T.W.,Trevillyan, J.M.,Stoll, V.S.
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45:7474-7482, 2006
PubMed: 16768443 (PDB entries with the same primary citation)
DOI: 10.1021/bi060184f
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256192.2%5.0%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2gbc
no rotation
Molmil generated image of 2gbc
rotated about x axis by 90°
Molmil generated image of 2gbc
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2gbc
no rotation
Molmil generated image of 2gbc
rotated about x axis by 90°
Molmil generated image of 2gbc
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2gbc.pdb1.gz [225.9 KB])
Coordinate files for Biological unit (2gbc.pdb2.gz [666.12 KB])