1QXB
 
 | | NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9 | | 分子名称: | 5'-d(CpGpCpGpApApTpTpCpGpCpG)-3', beta-D-ribofuranose | | 著者 | Nauwelaerts, K, Vastmans, K, Froeyen, M, Kempeneers, V, Rozenski, J, Rosemeyer, H, Van Aerschot, A, Busson, R, Efimtseva, E, Mikhailov, S, Lescrinier, E, Herdewijn, P. | | 登録日 | 2003-09-05 | | 公開日 | 2004-02-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.
Nucleic Acids Res., 31, 2003
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9GRV
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 37 | | 分子名称: | 5-bromanylpyrimidine, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | 登録日 | 2024-09-12 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9GRS
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 8 | | 分子名称: | 1-bromanyl-4-methylsulfonyl-benzene, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | 登録日 | 2024-09-12 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9GRT
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 29 | | 分子名称: | 4-bromo-1H-pyrazole, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | 登録日 | 2024-09-12 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9G96
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 42 | | 分子名称: | 1,2-ETHANEDIOL, 4-[[(5-bromanylpyridin-3-yl)methylamino]methyl]aniline, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | | 登録日 | 2024-07-24 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9G91
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 43 | | 分子名称: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | | 著者 | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | | 登録日 | 2024-07-24 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9G94
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9GRU
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 30 | | 分子名称: | 4-IODOPYRAZOLE, Hepatoma-derived growth factor-related protein 2, SULFATE ION | | 著者 | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | 登録日 | 2024-09-12 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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481D
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1D7Z
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7B6A
 | | BK Polyomavirus VP1 pentamer core (residues 30-299) | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, IODIDE ION, ... | | 著者 | Osipov, E.M, Munawar, A, Beelen, S, Strelkov, S.V. | | 登録日 | 2020-12-07 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.
Rsc Chem Biol, 3, 2022
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7B69
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7B6C
 | | BK Polyomavirus VP1 pentamer fusion with long C-terminal extended arm | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, Major capsid protein VP1,Major capsid protein VP1 | | 著者 | Osipov, E.M, Beelen, S, Strelkov, S.V. | | 登録日 | 2020-12-07 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | | 主引用文献 | Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors.
Rsc Chem Biol, 3, 2022
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7YP8
 | | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Leucyl-sulfamoyl 3-deazaadenosine | | 分子名称: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2022-08-02 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The essential role of a structured water in base recognition of Class II aminoacyl-tRNA synthetases
To be published
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6Q8A
 | | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine | | 分子名称: | 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine, Leucine--tRNA ligase, MAGNESIUM ION, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2018-12-14 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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6Q89
 | | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with the Intermediate Analog 5'-O-(N-(L-Leucyl)-Sulfamoyl)Adenosine | | 分子名称: | 1,2-ETHANEDIOL, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2018-12-14 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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6Q8C
 | | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine | | 分子名称: | 1,2-ETHANEDIOL, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, Leucine--tRNA ligase, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2018-12-14 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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6Q8B
 | | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)N3-methyluridine | | 分子名称: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2018-12-14 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
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7NTY
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7NU1
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7NU2
 | | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with the Reaction Intermediate Leu-AMP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | | 著者 | Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2021-03-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
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7NU9
 | | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP and L-leucinol | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2021-03-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
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7NU6
 | | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP in Conformation 1 | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | | 著者 | Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2021-03-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
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7NU5
 | | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with L-leucine | | 分子名称: | LEUCINE, Leucine--tRNA ligase, MAGNESIUM ION, ... | | 著者 | Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2021-03-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
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7NU4
 | | Crystal Structure of Neisseria gonorrhoeae LeuRS | | 分子名称: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | | 著者 | Pang, L, Strelkov, S.V, Weeks, S.D. | | 登録日 | 2021-03-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
Commun Biol, 5, 2022
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