5MHJ
 
 | | ICP4 DNA-binding domain, lacking intrinsically disordered region, in complex with 12mer DNA duplex from its own promoter | | 分子名称: | ACETIC ACID, CHLORIDE ION, DNA (5'-D(P*CP*GP*AP*TP*CP*GP*TP*CP*C)-3'), ... | | 著者 | Tunnicliffe, R.B, Lockhart-Cairns, M.P, Levy, C, Mould, P, Jowitt, T.A, Sito, H, Baldock, C, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2016-11-24 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.117 Å) | | 主引用文献 | The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
Nucleic Acids Res., 45, 2017
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5MHK
 | | ICP4 DNA-binding domain in complex with 19mer DNA duplex from its own promoter | | 分子名称: | CHLORIDE ION, DNA (5'-D(*GP*CP*TP*CP*CP*GP*TP*GP*TP*GP*GP*AP*CP*GP*AP*TP*CP*GP*G)-3'), ICP4 DNA BINDING DOMAIN, ... | | 著者 | Tunnicliffe, R.B, Lockhart-Cairns, M.P, Levy, C, Mould, P, Jowitt, T.A, Sito, H, Baldock, C, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2016-11-24 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
Nucleic Acids Res., 45, 2017
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2YKA
 | | RRM domain of mRNA export adaptor REF2-I bound to HVS ORF57 peptide | | 分子名称: | 52 KDA IMMEDIATE-EARLY PHOSPHOPROTEIN, RNA AND EXPORT FACTOR-BINDING PROTEIN 2 | | 著者 | Tunnicliffe, R.B, Hautbergue, G.M, Kalra, P, Wilson, S.A, Golovanov, A.P. | | 登録日 | 2011-05-26 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri Orf57 to the Mammalian Export Adaptor Alyref.
Plos Pathog., 10, 2014
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4YXP
 | | The structure of the folded domain of the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer. | | 分子名称: | ZINC ION, mRNA export factor | | 著者 | Tunnicliffe, R.B, Schacht, M, Levy, C.W, Jowitt, T.A, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2015-03-23 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.
Sci Rep, 5, 2015
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6HAU
 | | KSHV PAN RNA Mta-response element fragment complexed with the globular domain of herpesvirus saimiri ORF57 | | 分子名称: | ACETATE ION, MRE fragment of PAN RNA, ZINC ION, ... | | 著者 | Tunnicliffe, R.B, Levy, C, Ruiz Nivia, H.D, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2018-08-08 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition.
Nucleic Acids Res., 47, 2019
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6HAT
 | | Globular domain of herpesvirus saimiri ORF57 | | 分子名称: | ACETATE ION, ZINC ION, mRNA export factor ICP27 homolog | | 著者 | Tunnicliffe, R.B, Levy, C, Ruiz Nivia, H.D, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2018-08-08 | | 公開日 | 2018-11-21 | | 最終更新日 | 2022-03-30 | | 実験手法 | X-RAY DIFFRACTION (1.856 Å) | | 主引用文献 | Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition.
Nucleic Acids Res., 47, 2019
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2NRG
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6FAD
 | | SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27 | | 分子名称: | PHOSPHATE ION, SRSF protein kinase 1, mRNA export factor | | 著者 | Tunnicliffe, R.B, Levy, C, Mould, A.P, Mckenzie, E.A, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2017-12-15 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27.
Mbio, 10, 2019
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2ITA
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2BGO
 | | Mannan Binding Module from Man5C | | 分子名称: | ENDO-B1,4-MANNANASE 5C | | 著者 | Tunnicliffe, R.B, Bolam, D.N, Pell, G, Gilbert, H.J, Williamson, M.P. | | 登録日 | 2005-01-04 | | 公開日 | 2005-03-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Mannan-Specific Family 35 Carbohydrate-Binding Module: Evidence for Significant Conformational Changes Upon Ligand Binding
J.Mol.Biol., 347, 2005
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2BGP
 | | Mannan Binding Module from Man5C in bound conformation | | 分子名称: | ENDO-B1,4-MANNANASE 5C | | 著者 | Tunnicliffe, R.B, Bolam, D.N, Pell, G, Gilbert, H.J, Williamson, M.P. | | 登録日 | 2005-01-04 | | 公開日 | 2005-03-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Mannan-Specific Family 35 Carbohydrate-Binding Module: Evidence for Significant Conformational Changes Upon Ligand Binding
J.Mol.Biol., 347, 2005
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2J53
 | | Solution Structure of GB1 domain Protein G and low and high pressure. | | 分子名称: | IMMUNOGLOBULIN G-BINDING PROTEIN G | | 著者 | Wilton, D.J, Tunnicliffe, R.B, Kamatari, Y.O, Akasaka, K, Williamson, M.P. | | 登録日 | 2006-09-11 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Pressure-Induced Changes in the Solution Structure of the Gb1 Domain of Protein G.
Proteins, 71, 2008
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2J4M
 | | Double dockerin from Piromyces equi Cel45A | | 分子名称: | ENDOGLUCANASE 45A | | 著者 | Nagy, T, Tunnicliffe, R.B, Higgins, L.D, Walters, C, Gilbert, H.J, Williamson, M.P. | | 登録日 | 2006-09-01 | | 公開日 | 2007-09-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Characterization of a Double Dockerin from the Cellulosome of the Anaerobic Fungus Piromyces Equi.
J.Mol.Biol., 373, 2007
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2J4N
 | | Double dockerin from Piromyces equi Cel45A | | 分子名称: | ENDOGLUCANASE 45A | | 著者 | Nagy, T, Tunnicliffe, R.B, Higgins, L.D, Walters, C, Gilbert, H.J, Williamson, M.P. | | 登録日 | 2006-09-01 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Characterization of a Double Dockerin from the Cellulosome of the Anaerobic Fungus Piromyces Equi.
J.Mol.Biol., 373, 2007
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2J52
 | | Solution Structure of GB1 domain Protein G and low and high pressure. | | 分子名称: | IMMUNOGLOBULIN G-BINDING PROTEIN G | | 著者 | Wilton, D.J, Tunnicliffe, R.B, Kamatari, Y.O, Akasaka, K, Williamson, M.P. | | 登録日 | 2006-09-11 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Pressure-Induced Changes in the Solution Structure of the Gb1 Domain of Protein G.
Proteins, 71, 2008
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2KT5
 | | RRM domain of mRNA export adaptor REF2-I bound to HSV-1 ICP27 peptide | | 分子名称: | ICP27, RNA and export factor-binding protein 2 | | 著者 | Tunnicliffe, N.B, Golovanov, A.P, Wilson, S.A, Hautbergue, G.M. | | 登録日 | 2010-01-18 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57.
Plos Pathog., 7, 2011
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7QKE
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with inhibitor (surface entropy reduction mutant) | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Steroid C26-monooxygenase, ethyl 1-(cyclohexylmethyl)-5-pyridin-4-yl-indole-2-carboxylate | | 著者 | Snee, M, Tunnicliffe, R, Leys, D, Levy, C, Katariya, M. | | 登録日 | 2021-12-17 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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7QNN
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with inhibitor (surface entropy reduction mutant) | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Steroid C26-monooxygenase, ethyl 1-(cyclopentylmethyl)-5-pyridin-4-yl-indole-2-carboxylate | | 著者 | Snee, M, Tunnicliffe, R, Leys, D, Levy, C, Katariya, M. | | 登録日 | 2021-12-21 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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7ZQR
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | | 分子名称: | 4-(4-methoxyphenyl)pyridine, CHLORIDE ION, GLYCEROL, ... | | 著者 | Snee, M, Katariya, M, Tunnicliffe, R, Levy, C, Leys, D. | | 登録日 | 2022-05-02 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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2WZ8
 | | Family 35 carbohydrate binding module from Clostridium thermocellum | | 分子名称: | CALCIUM ION, CELLULOSOME PROTEIN DOCKERIN TYPE I, MAGNESIUM ION | | 著者 | Gloster, T.M, Davies, G.J, Fontes, C.M, Gilbert, H.J. | | 登録日 | 2009-11-25 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module .
Biochemistry, 49, 2010
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6QB2
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7QJL
 | | Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with an inhibitor | | 分子名称: | ACETATE ION, BROMIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Snee, M, Levy, C, Katariya, M. | | 登録日 | 2021-12-16 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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7QWN
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | | 分子名称: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | | 著者 | Snee, M, Katariya, M, Levy, C, Leys, D. | | 登録日 | 2022-01-25 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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7YXF
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | | 分子名称: | 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | | 著者 | Snee, M, Katariya, M, Levy, C, Leys, D. | | 登録日 | 2022-02-16 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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7ZT0
 | | Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor | | 分子名称: | 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole-2-carboxamide, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Snee, M, Katariya, M, Levy, C, Leys, D. | | 登録日 | 2022-05-09 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry, 29, 2023
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