6C4P
| Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PMP Complex | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CALCIUM ION, ... | 著者 | Kreinbring, C.A, Tu, Y, Liu, D, Berkowitz, D.B, Petsko, G.A, Ringe, D. | 登録日 | 2018-01-12 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
|
|
6C2H
| Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the Catalytic Core | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D. | 登録日 | 2018-01-08 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
|
|
6C2Q
| Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-L-Serine Intermediate | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D. | 登録日 | 2018-01-08 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
|
|
6C2Z
| Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-Aminoacrylate Intermediate | 分子名称: | 1,2-ETHANEDIOL, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CALCIUM ION, ... | 著者 | Kreinbring, C.A, Tu, Y, Liu, D, Petsko, G.A, Ringe, D. | 登録日 | 2018-01-09 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 57, 2018
|
|
7X1Z
| Structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | 登録日 | 2022-02-25 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex Nat Commun, 14, 2023
|
|
7X1Y
| Structure of the phosphorylation-site double mutant S431A/T432A of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | 登録日 | 2022-02-25 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex Nat Commun, 14, 2023
|
|
8TS1
| Cryo-EM structure of human MRS2 with Mg2+ | 分子名称: | MAGNESIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | 著者 | He, Z, Mount, J.W, Zhang, J, Yuan, P. | 登録日 | 2023-08-10 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Human mitochondrial MRS2 is a Ca2+-regulated nonselective cation channel To Be Published
|
|
8TS3
| Cryo-EM structure of human MRS2 with Ca2+ | 分子名称: | CALCIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | 著者 | He, Z, Mount, J.W, Zhang, J, Yuan, P. | 登録日 | 2023-08-10 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Human mitochondrial MRS2 is a Ca2+-regulated nonselective cation channel To Be Published
|
|
8TS2
| |
4AFX
| Crystal structure of the reactive loop cleaved ZPI in I2 space group | 分子名称: | CALCIUM ION, PHOSPHATE ION, PROTEIN Z DEPENDENT PROTEASE INHIBITOR, ... | 著者 | Zhou, A, Yan, Y, Wei, Z. | 登録日 | 2012-01-23 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z. Blood, 120, 2012
|
|
4AJU
| Crystal structure of the reactive loop cleaved ZPI in P41 space group | 分子名称: | 1,2-ETHANEDIOL, PROTEIN Z-DEPENDENT PROTEASE INHIBITOR, SULFATE ION | 著者 | Zhou, A, Yan, Y, Wei, Z. | 登録日 | 2012-02-19 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z. Blood, 120, 2012
|
|
4AJT
| |
8Z9M
| Cryo-EM structure of dimeric WDR11-FAM91A1 complex | 分子名称: | Protein FAM91A1, WD repeat-containing protein 11 | 著者 | Jia, G.W, Deng, Q.H, Su, Z.M, Jia, D. | 登録日 | 2024-04-23 | 公開日 | 2024-08-14 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins. Cell, 187, 2024
|
|
6AKR
| Crystal structure of the PDE4D catalytic domain in complex with osthole | 分子名称: | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 著者 | Wang, S, Huo, Y.W, Xie, Y. | 登録日 | 2018-09-03 | 公開日 | 2020-02-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.326 Å) | 主引用文献 | Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma. Sci.Signal., 13, 2020
|
|
4NLD
| Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide | 分子名称: | (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ... | 著者 | Sheriff, S. | 登録日 | 2013-11-14 | 公開日 | 2014-03-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase. J.Med.Chem., 57, 2014
|
|
4NWK
| Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide | 分子名称: | GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ... | 著者 | Muckelbauer, J.K, Klei, H.E. | 登録日 | 2013-12-06 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
|
|
4NWL
| Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide | 分子名称: | HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION | 著者 | Muckelbauer, J.K, Klei, H.E. | 登録日 | 2013-12-06 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
|
|
7YF5
| |
8XFB
| Cryo-EM structure of partial dimeric WDR11-FAM91A1 complex | 分子名称: | Protein FAM91A1, WD repeat-containing protein 11 | 著者 | Jia, G.W, Deng, Q.H, Su, Z.M, Jia, D. | 登録日 | 2023-12-13 | 公開日 | 2024-08-14 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins. Cell, 187, 2024
|
|
3P9C
| Crystal structure of perennial ryegrass LpOMT1 bound to SAH | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Louie, G.V, Noel, J.P, Bowman, M.E. | 登録日 | 2010-10-17 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference. Plant Cell, 22, 2010
|
|
3P9I
| Crystal structure of perennial ryegrass LpOMT1 complexed with S-adenosyl-L-homocysteine and sinapaldehyde | 分子名称: | (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enal, BETA-MERCAPTOETHANOL, Caffeic acid O-methyltransferase, ... | 著者 | Louie, G.V, Noel, J.P, Bowman, M.E. | 登録日 | 2010-10-17 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference. Plant Cell, 22, 2010
|
|
3P9K
| |
5YI8
| |
5YI7
| |
6WT3
| Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase | 分子名称: | 5D2 FAB HEAVY CHAIN, 5D2 FAB LIGHT CHAIN | 著者 | Luz, J.G, Birrane, G, Young, S.G, Meiyappan, M, Ploug, M. | 登録日 | 2020-05-01 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J.Lipid Res., 61, 2020
|
|