4V0I
 
 | | Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta | | 分子名称: | 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM | | 著者 | Robinson, D, Bertrand, T, Carry, J.C, Halley, F, Karlsson, A, Mathieu, M, Minoux, H, Perrin, M.A, Robert, B, Schio, L, Sherman, W. | | 登録日 | 2014-09-16 | | 公開日 | 2015-09-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications.
J.Chem.Inf.Model., 56, 2016
|
|
6YHS
 | | Acinetobacter baumannii ribosome-amikacin complex - 50S subunit | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-03-30 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
6YPU
 | | Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body | | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S ribosomal RNA, 30S ribosomal protein S11, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-04-16 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
6YS5
 | | Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
6YTF
 | | Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-04-24 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
6YT9
 | | Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit body | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-04-24 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
7QEP
 | | Cryo-EM structure of the ribosome from Encephalitozoon cuniculi | | 分子名称: | 18S ribosomal RNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | | 著者 | Nicholson, D, Ranson, N.A, Melnikov, S.V. | | 登録日 | 2021-12-03 | | 公開日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Adaptation to genome decay in the structure of the smallest eukaryotic ribosome
Nat Commun, 13, 2022
|
|
6YSI
 | | Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | | 登録日 | 2020-04-22 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
Structure, 28, 2020
|
|
1T2X
 | | Glactose oxidase C383S mutant identified by directed evolution | | 分子名称: | ACETATE ION, COPPER (II) ION, Galactose Oxidase, ... | | 著者 | Wilkinson, D, Akumanyi, N, Hurtado-Guerrero, R, Dawkes, H, Knowles, P.F, Phillips, S.E.V, McPherson, M.J. | | 登録日 | 2004-04-23 | | 公開日 | 2004-05-18 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and kinetic studies of a series of mutants of galactose oxidase identified by directed evolution.
Protein Eng.Des.Sel., 17, 2004
|
|
1GYK
 | | Serum Amyloid P Component co-crystallised with MOBDG at neutral pH | | 分子名称: | CALCIUM ION, METHYL 4,6-O-[(1R)-1-CARBOXYETHYLIDENE]-BETA-D-GALACTOPYRANOSIDE, SERUM AMYLOID P-COMPONENT | | 著者 | Thompson, D, Pepys, M.B, Tickle, I, Wood, S.P. | | 登録日 | 2002-04-25 | | 公開日 | 2003-05-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Structures of Crystalline Complexes of Human Serum Amyloid P Component with its Carbohydrate Ligand, the Cyclic Pyruvate Acetal of Galactose
J.Mol.Biol., 320, 2002
|
|
2JD4
 | | Mouse laminin alpha1 chain, domains LG4-5 | | 分子名称: | CHLORIDE ION, LAMININ SUBUNIT ALPHA-1, MAGNESIUM ION | | 著者 | Harrison, D, Hussain, S.A, Combs, A.C, Ervasti, J.M, Yurchenco, P.D, Hohenester, E. | | 登録日 | 2007-01-04 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure and Cell Surface Anchorage Sites of Laminin {Alpha}1Lg4-5.
J.Biol.Chem., 282, 2007
|
|
1YF0
 | | Structural and biochemical analysis of the link between enzymatic activity and oligomerization in AhpC, a bacterial peroxiredoxin. | | 分子名称: | Alkyl hydroperoxide reductase subunit C, SULFATE ION | | 著者 | Parsonage, D, Youngblood, D.S, Sarma, G.N, Wood, Z.A, Karplus, P.A, Poole, L.B. | | 登録日 | 2004-12-29 | | 公開日 | 2005-08-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
|
|
1YF1
 | | Structural and biochemical analysis of the link between enzymatic activity and oligomerization in AhpC, a bacterial peroxiredoxin. | | 分子名称: | Alkyl hydroperoxide reductase subunit C, SODIUM ION | | 著者 | Parsonage, D, Youngblood, D.S, Sarma, G.N, Wood, Z.A, Karplus, P.A, Poole, L.B. | | 登録日 | 2004-12-29 | | 公開日 | 2005-08-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
|
|
1YEP
 | | Structural and biochemical analysis of the link between enzymatic activity and olgomerization in AhpC, a bacterial peroxiredoxin. | | 分子名称: | Alkyl hydroperoxide reductase subunit C, SULFATE ION | | 著者 | Parsonage, D, Youngblood, D.S, Sarma, G.N, Wood, Z.A, Karplus, P.A, Poole, L.B. | | 登録日 | 2004-12-28 | | 公開日 | 2005-08-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
|
|
1YEX
 | | Structural and biochemical analysis of the link between enzymatic activity and oligomerization in AhpC, a bacterial peroxiredoxin. | | 分子名称: | Alkyl hydroperoxide reductase subunit C, SULFATE ION | | 著者 | Parsonage, D, Youngblood, D.S, Sarma, G.N, Wood, Z.A, Karplus, P.A, Poole, L.B. | | 登録日 | 2004-12-28 | | 公開日 | 2005-08-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Analysis of the Link between Enzymatic Activity and Oligomeric State in AhpC, a Bacterial Peroxiredoxin.
Biochemistry, 44, 2005
|
|
4CW9
 | | Entamoeba histolytica thiredoxin C34S mutant | | 分子名称: | THIOREDOXIN | | 著者 | Parsonage, D, Kells, P.M, Vieira, D.F, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | | 登録日 | 2014-04-01 | | 公開日 | 2015-05-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.
J.Struct.Biol., 194, 2016
|
|
4CCR
 | | Crystal structure of the thioredoxin reductase apoenzyme from Entamoeba histolytica in the absence of the NADP cofactor | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION, THIOREDOXIN REDUCTASE | | 著者 | Parsonage, D, Kells, P.M, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | | 登録日 | 2013-10-25 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.
J.Struct.Biol., 194, 2016
|
|
4CBQ
 | | Crystal structure of the thioredoxin reductase from Entamoeba histolytica with auranofin Au(I) bound to Cys286 | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION, ... | | 著者 | Parsonage, D, Kells, P.M, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | | 登録日 | 2013-10-16 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.
J.Struct.Biol., 194, 2016
|
|
4CCQ
 | | Crystal structure of the thioredoxin reductase from Entamoeba histolytica with NADP | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Parsonage, D, Kells, P.M, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | | 登録日 | 2013-10-24 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.
J.Struct.Biol., 194, 2016
|
|
1B09
 | |
7P48
 | | Staphylococcus aureus ribosome in complex with Sal(B) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Nicholson, D, Ranson, N.A, O'Neill, A.J. | | 登録日 | 2021-07-09 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Nucleic Acids Res., 50, 2022
|
|
7E23
 | | SARS-CoV-2 spike in complex with the CA521 neutralizing antibody Fab (focused refinement on Fab-RBD) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CA521 Heavy Chain, CA521 Light Chain, ... | | 著者 | Liu, C, Song, D, Dou, C. | | 登録日 | 2021-02-04 | | 公開日 | 2021-05-05 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2.
Commun Biol, 4, 2021
|
|
5HNR
 | | The X-ray structure of octameric human native 5-aminolaevulinic acid dehydratase. | | 分子名称: | DELTA-AMINO VALERIC ACID, Delta-aminolevulinic acid dehydratase, SULFATE ION, ... | | 著者 | Mills-Davies, N.L, Thompson, D, Shoolingin-Jordan, P.M, Erskine, P.T, Cooper, J.B. | | 登録日 | 2016-01-18 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis.
Acta Crystallogr D Struct Biol, 73, 2017
|
|
1N28
 | | Crystal structure of the H48Q mutant of human group IIA phospholipase A2 | | 分子名称: | CALCIUM ION, Phospholipase A2, membrane associated | | 著者 | Edwards, S.H, Thompson, D, Baker, S.F, Wood, S.P, Wilton, D.C. | | 登録日 | 2002-10-22 | | 公開日 | 2003-10-28 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism
Biochemistry, 41, 2002
|
|
5IPG
 | | Xanthomonas campestris Peroxiredoxin Q - Structure FFT-butyl (Hyperoxodized by t-butyl hydroperoxide) | | 分子名称: | Bacterioferritin comigratory protein, SODIUM ION | | 著者 | Perkins, A, Parsonage, D, Nelson, K.J, Poole, L.B, Karplus, A. | | 登録日 | 2016-03-09 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Peroxiredoxin Catalysis at Atomic Resolution.
Structure, 24, 2016
|
|
