8HAE
| Cryo-EM structure of HACE1 dimer | 分子名称: | E3 ubiquitin-protein ligase HACE1 | 著者 | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J, Machida, S. | 登録日 | 2022-10-26 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (4.55 Å) | 主引用文献 | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
|
|
8H8X
| Cryo-EM structure of HACE1 monomer | 分子名称: | E3 ubiquitin-protein ligase HACE1 | 著者 | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J. | 登録日 | 2022-10-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
|
|
3GWZ
| Structure of the Mitomycin 7-O-methyltransferase MmcR | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, MmcR, ... | 著者 | Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S. | 登録日 | 2009-04-01 | 公開日 | 2010-04-07 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural characterization of the mitomycin 7-O-methyltransferase. Proteins, 79, 2011
|
|
3GXO
| Structure of the Mitomycin 7-O-methyltransferase MmcR with bound Mitomycin A | 分子名称: | CALCIUM ION, MmcR, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S. | 登録日 | 2009-04-02 | 公開日 | 2010-04-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural characterization of the mitomycin 7-O-methyltransferase. Proteins, 79, 2011
|
|
6MRO
| Crystal structure of methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution, Northeast Structural Genomics Consortium (NESG) Target MvR53. | 分子名称: | CALCIUM ION, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Singh, S, Forouhar, F, Wang, C, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2018-10-15 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of a methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution. To Be Published
|
|
5YDD
| Crystal structure of C-terminal domain of Rv1828 from Mycobacterium tuberculosis | 分子名称: | (6R,8S,9S)-8-(hydroxymethyl)-6,11,11-tris(oxidanyl)-9-propyl-dodecanoic acid, GLYCEROL, SODIUM ION, ... | 著者 | Singh, S, Karthiekeyan, S. | 登録日 | 2017-09-12 | 公開日 | 2018-09-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Characteristics of the essential pathogenicity factor Rv1828, a MerR family transcription regulator from Mycobacterium tuberculosis. FEBS J., 285, 2018
|
|
5YDC
| |
7MU4
| |
7MX8
| |
7MYT
| |
1KFT
| Solution Structure of the C-Terminal domain of UvrC from E-coli | 分子名称: | Excinuclease ABC subunit C | 著者 | Singh, S, Folkers, G.E, Bonvin, A.M.J.J, Boelens, R, Wechselberger, R, Niztayev, A, Kaptein, R. | 登録日 | 2001-11-23 | 公開日 | 2002-11-20 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and DNA-binding properties of the C-terminal domain of UvrC from E.coli EMBO J., 21, 2002
|
|
1XO3
| Solution Structure of Ubiquitin like protein from Mus Musculus | 分子名称: | RIKEN cDNA 2900073H19 | 著者 | Singh, S, Tonelli, M, Tyler, R.C, Bahrami, A, Lee, M.S, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2004-10-05 | 公開日 | 2004-10-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. Protein Sci., 14, 2005
|
|
1ZXF
| Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora | 分子名称: | CalC | 著者 | Singh, S, Hager, M.H, Zhang, C, Griffith, B.R, Lee, M.S, Hallenga, K, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2005-06-08 | 公開日 | 2005-12-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006
|
|
2GKD
| |
1XO8
| Solution structure of AT1g01470 from Arabidopsis Thaliana | 分子名称: | At1g01470 | 著者 | Singh, S, Cornilescu, C.C, Tyler, R.C, Cornilescu, G, Tonelli, M, Lee, M.S, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2004-10-06 | 公開日 | 2004-10-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a late embryogenesis abundant protein (LEA14) from Arabidopsis thaliana, a cellular stress-related protein Protein Sci., 14, 2005
|
|
6K16
| |
7E9R
| |
7E6W
| |
2L65
| HADDOCK calculated model of the complex of the resistance protein CalC and Calicheamicin-Gamma | 分子名称: | 2,4-dideoxy-4-(ethylamino)-3-O-methyl-alpha-L-threo-pentopyranose-(1-2)-4-amino-4,6-dideoxy-beta-D-glucopyranose, 2,6-dideoxy-4-thio-beta-D-allopyranose, 3-O-methyl-alpha-L-rhamnopyranose, ... | 著者 | Singh, S, Markley, J.L, Thorson, J.S, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2010-11-15 | 公開日 | 2011-03-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006
|
|
3BUS
| Crystal Structure of RebM | 分子名称: | Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | McCoy, J.G, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N. | 登録日 | 2008-01-03 | 公開日 | 2008-03-25 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM. J.Biol.Chem., 283, 2008
|
|
6EBE
| Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. | 分子名称: | 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Singh, S, McKenna, R, Supuran, C.T, Nocentini, A, Lomelino, C, Lucarini, E, Bartolucci, G, Mannelli, L.D.C, Ghelardini, C, Gratteri, P. | 登録日 | 2018-08-06 | 公開日 | 2018-11-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem., 61, 2018
|
|
6EEA
| Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. | 分子名称: | 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION | 著者 | Singh, S, McKenna, R, Supuran, C.T, Nocentini, A, Lomelino, C, Lucarini, E, Bartolucci, G, Mannelli, L.D.C, Ghelardini, C, Gratteri, P. | 登録日 | 2018-08-13 | 公開日 | 2018-11-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem., 61, 2018
|
|
4XAU
| Crystal structure of AtS13 from Actinomadura melliaura | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Putative aminotransferase | 著者 | Wang, F, Singh, S, Xu, W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-12-15 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.0012 Å) | 主引用文献 | Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis. Proteins, 83, 2015
|
|
4XRR
| Crystal structure of cals8 from micromonospora echinospora (P294S mutant) | 分子名称: | CalS8, GLYCEROL | 著者 | Michalska, K, Bigelow, L, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2015-01-21 | 公開日 | 2015-02-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. J. Biol. Chem., 290, 2015
|
|
6XQW
| |