3ZI5
 
 | | Crystal STRUCTURE OF RESTRICTION ENDONUCLEASE BFII C-TERMINAL RECOGNITION DOMAIN IN COMPLEX WITH COGNATE DNA | | 分子名称: | 5'-D(*AP*GP*CP*AP*CP*TP*GP*GP*GP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*CP*CP*CP*AP*GP*TP*GP*CP*TP)-3', RESTRICTION ENDONUCLEASE | | 著者 | Golovenko, D, Manakova, E, Zakrys, L, Zaremba, M, Sasnauskas, G, Grazulis, S, Siksnys, V. | | 登録日 | 2013-01-03 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural Insight Into the Specificity of the B3 DNA-Binding Domains Provided by the Co-Crystal Structure of the C-Terminal Fragment of Bfii Restriction Enzyme
Nucleic Acids Res., 42, 2014
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3BM3
 | | Restriction endonuclease PspGI-substrate DNA complex | | 分子名称: | CITRIC ACID, DNA (5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3'), ... | | 著者 | Szczepanowski, R.H, Carpenter, M, Czapinska, H, Tamulaitis, G, Siksnys, V, Bhagwat, A, Bochtler, M. | | 登録日 | 2007-12-12 | | 公開日 | 2008-09-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A direct crystallographic demonstration that Type II restriction endonuclease PspGI flips nucleotides
To be Published
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2IXS
 | | Structure of SdaI restriction endonuclease | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SDAI RESTRICTION ENDONUCLEASE, ... | | 著者 | Tamulaitiene, G, Jakubauskas, A, Urbanke, C, Huber, R, Grazulis, S, Siksnys, V. | | 登録日 | 2006-07-11 | | 公開日 | 2006-09-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Crystal Structure of the Rare-Cutting Restriction Enzyme Sdai Reveals Unexpected Domain Architecture
Structure, 14, 2006
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4ABT
 | | Crystal structure of Type IIF restriction endonuclease NgoMIV with cognate uncleaved DNA | | 分子名称: | 5'-D(*TP*GP*CP*GP*CP*CP*GP*GP*CP*GP*CP)-3', CALCIUM ION, TYPE-2 RESTRICTION ENZYME NGOMIV | | 著者 | Manakova, E.N, Grazulis, S, Zaremba, M, Tamulaitiene, G, Golovenko, D, Siksnys, V. | | 登録日 | 2011-12-11 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structure of Type Iif Restriction Endonuclease Ngomiv with Cognate Uncleaved DNA
To be Published
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3IMB
 | | Alternative binding mode of restriction endonuclease BcnI to cognate DNA | | 分子名称: | 5'-D(*CP*GP*CP*CP*CP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*GP*GP*GP*CP*G)-3', R.BcnI | | 著者 | Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Siksnys, V, Bochtler, M. | | 登録日 | 2009-08-10 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | How BcnI and MvaI distinguish W from S
To be Published
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8PM4
 | | Cryo-EM structure of the Cas12m-crRNA-target DNA complex | | 分子名称: | DNA oligoduplex, non-target strand, chain D, ... | | 著者 | Sasnauskas, G, Tamulaitiene, G, Karvelis, T, Bigelyte, G, Siksnys, V. | | 登録日 | 2023-06-28 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.
Nucleic Acids Res., 52, 2024
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1KNV
 | | Bse634I restriction endonuclease | | 分子名称: | ACETATE ION, Bse634I restriction endonuclease, CHLORIDE ION | | 著者 | Grazulis, S, Deibert, M, Rimseliene, R, Skirgaila, R, Sasnauskas, G, Lagunavicius, A, Repin, V, Urbanke, C, Huber, R, Siksnys, V. | | 登録日 | 2001-12-19 | | 公開日 | 2002-02-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence.
Nucleic Acids Res., 30, 2002
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4RZL
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2FQZ
 | | Metal-depleted Ecl18kI in complex with uncleaved DNA | | 分子名称: | DNA STRAND 1, DNA STRAND 2, R.Ecl18kI | | 著者 | Bochtler, M, Szczepanowski, R.H, Tamulaitis, G, Grazulis, S, Czapinska, H, Manakova, E, Siksnys, V. | | 登録日 | 2006-01-18 | | 公開日 | 2006-06-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease
Embo J., 25, 2006
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2GB7
 | | Metal-depleted Ecl18kI in complex with uncleaved, modified DNA | | 分子名称: | DNA STRAND 1, DNA STRAND 2, R.Ecl18kI | | 著者 | Bochtler, M, Szczepanowski, R.H, Tamulaitis, G, Grazulis, S, Czapinska, H, Manakova, E, Siksnys, V. | | 登録日 | 2006-03-10 | | 公開日 | 2006-06-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease
Embo J., 25, 2006
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4RCT
 | | Crystal structure of R-protein of NgoAVII restriction endonuclease | | 分子名称: | Restriction endonuclease R.NgoVII | | 著者 | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | | 登録日 | 2014-09-17 | | 公開日 | 2014-12-24 | | 最終更新日 | 2014-12-31 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
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4RD5
 | | Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA | | 分子名称: | DNA (5'-D(*CP*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*GP*G)-3'), Restriction endonuclease R.NgoVII | | 著者 | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | | 登録日 | 2014-09-18 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
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4RDM
 | | Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA | | 分子名称: | DNA (5'-D(*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3)', DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*G)-3)', Restriction endonuclease R.NgoVII, ... | | 著者 | Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V. | | 登録日 | 2014-09-19 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
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8EXA
 | | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 1 (RuvC domain resolved) | | 分子名称: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | | 著者 | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | | 登録日 | 2022-10-25 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | TnpB structure reveals minimal functional core of Cas12 nuclease family.
Nature, 616, 2023
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8EX9
 | | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 2 (RuvC domain unresolved) | | 分子名称: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | | 著者 | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | | 登録日 | 2022-10-25 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | TnpB structure reveals minimal functional core of Cas12 nuclease family.
Nature, 616, 2023
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4ZSF
 | | Crystal structure of pre-specific restriction endonuclease BsaWI-DNA complex | | 分子名称: | BsaWI endonuclease, CALCIUM ION, DNA, ... | | 著者 | Tamulaitiene, G, Rutkauskas, M, Grazulis, S, Siksnys, V. | | 登録日 | 2015-05-13 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Functional significance of protein assemblies predicted by the crystal structure of the restriction endonuclease BsaWI.
Nucleic Acids Res., 43, 2015
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4QDL
 | | Crystal structure of E.coli Cas1-Cas2 complex | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 | | 著者 | Tamulaitiene, G, Sinkunas, T, Silanskas, A, Gasiunas, G, Grazulis, S, Siksnys, V. | | 登録日 | 2014-05-14 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of E.coli Cas1-Cas2 complex
To be Published
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6GHC
 | | Modification dependent EcoKMcrA restriction endonuclease | | 分子名称: | 5-methylcytosine-specific restriction enzyme A, ZINC ION | | 著者 | Czapinska, H, Kowalska, M, Zagorskaite, E, Manakova, E, Xu, S, Siksnys, V, Sasnauskas, G, Bochtler, M. | | 登録日 | 2018-05-07 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Activity and structure of EcoKMcrA.
Nucleic Acids Res., 46, 2018
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1FIU
 | | TETRAMERIC RESTRICTION ENDONUCLEASE NGOMIV IN COMPLEX WITH CLEAVED DNA | | 分子名称: | ACETIC ACID, DNA (5'-D(*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*CP*GP*C)-3'), ... | | 著者 | Deibert, M, Grazulis, S, Sasnauskas, G, Siksnys, V, Huber, R. | | 登録日 | 2000-08-07 | | 公開日 | 2001-02-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA.
Nat.Struct.Biol., 7, 2000
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2C1L
 | | Structure of the BfiI restriction endonuclease | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICARBONATE ION, ... | | 著者 | Grazulis, S, Manakova, E, Roessle, M, Bochtler, M, Tamulaitiene, G, Huber, R, Siksnys, V. | | 登録日 | 2005-09-15 | | 公開日 | 2005-10-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the Metal-Independent Restriction Enzyme Bfii Reveals Fusion of a Specific DNA-Binding Domain with a Nonspecific Nuclease.
Proc.Natl.Acad.Sci.USA, 102, 2005
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2OAA
 | | Restriction endonuclease MvaI-cognate DNA substrate complex | | 分子名称: | 5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3', 5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3', CALCIUM ION, ... | | 著者 | Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M. | | 登録日 | 2006-12-15 | | 公開日 | 2007-02-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007
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2Q10
 | | RESTRICTION ENDONUCLEASE BcnI (WILD TYPE)-COGNATE DNA SUBSTRATE COMPLEX | | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*CP*CP*GP*GP*AP*GP*AP*C)-3'), ... | | 著者 | Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, C, Siksnys, V, Bochtler, M. | | 登録日 | 2007-05-23 | | 公開日 | 2007-06-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Monomeric Restriction Endonuclease BcnI in the Apo Form and in an Asymmetric Complex with Target DNA.
J.Mol.Biol., 369, 2007
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2ODH
 | | Restriction Endonuclease BCNI in the Absence of DNA | | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, R.BcnI | | 著者 | Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M. | | 登録日 | 2006-12-22 | | 公開日 | 2007-03-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA.
J.Mol.Biol., 369, 2007
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2ODI
 | | Restriction Endonuclease BCNI-Cognate DNA Substrate Complex | | 分子名称: | 5'-D(*AP*AP*CP*CP*CP*GP*GP*AP*GP*AP*C)-3', 5'-D(*CP*TP*CP*CP*GP*GP*GP*TP*TP*GP*T)-3', CALCIUM ION, ... | | 著者 | Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, C, Siksnys, V, Bochtler, M. | | 登録日 | 2006-12-22 | | 公開日 | 2007-03-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA.
J.Mol.Biol., 369, 2007
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2OA9
 | | Restriction endonuclease MvaI in the absence of DNA | | 分子名称: | ACETATE ION, CADMIUM ION, CHLORIDE ION, ... | | 著者 | Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M. | | 登録日 | 2006-12-15 | | 公開日 | 2007-02-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007
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